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    FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES
    6.
    发明公开
    FUSED RING SPIROKETAL DERIVATIVE AND USE THEREOF AS DRUG FOR TREATING DIABETES 审中-公开
    SPIROKETALDERIVATE稠环和其作为药物治疗糖尿病

    公开(公告)号：EP2048152A1

    公开(公告)日：2009-04-15

    申请号：EP07791496.8

    申请日：2007-07-27

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

    发明人： SATO, Tsutomu ,  OHTAKE, Yoshihito ,  NISHIMOTO, Masahiro ,  EMURA, Takashi ,  KOBAYASHI, Takamitsu ,  YAMAGUCHI, Marina ,  TAKAMI, Kyouko

    IPC分类号： C07H19/01 ,  A61K31/7048 ,  A61K31/7056 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00

    CPC分类号： C07H19/01

    摘要： Provided are a compound represented by Formula (I):

    wherein R 1 , R 2 , R 3 , and R 4 are each independently selected from a hydrogen atom, a C 1-6 alkyl group which may be substituted, a C 7-14 aralkyl group which may be substituted and -C(=O)Rx; n denotes an integer selected from 1 and 2; and ring Ar is selected from the groups represented by the following Formula (a) to (f).


    , or a prodrug thereof or a pharmaceutically acceptable salt thereof as well as a pharmaceutical agent and a pharmaceutical composition containing such a compound or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供由式（I）表示的化合物：其中R 1，R 2，R 3，和R 4各自独立地选自氢原子，可被取代的C 1-6烷基团，一个C 7-14 可被取代的芳烷基和基团-C（= O）的Rx; n表示选自1和2选择的整数; 和环Ar为从由下式（A）至（f）表示的基团。 或其前药或其药学上可接受的盐以及药物制剂和含有寻求的化合物或其前药的药物组合物，或其药学上可接受的盐。

    "> 4
    7.
    发明授权
    4"-DEOXY-4"-(S)-AMINO AVERMECTIN DERIVATIVES 有权
    4 '' - 脱氧-4 '' - （S） - 氨基阿维菌素衍生物

    公开(公告)号：EP1421094B1

    公开(公告)日：2008-10-15

    申请号：EP02767411.8

    申请日：2002-08-20

    申请人： Merial Limited

    发明人： TOBLER, Hans

    IPC分类号： C07H19/01 ,  A01N43/90

    CPC分类号： C07H19/01 ,  A01N43/90

    摘要： A description is given of compounds of the formula which in the 4"-position has the (S-)configuration and wherein R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is hydrogen, optionally substituted C1-C12alkyl or optionally substituted C2-C12alkenyl; R3 is C1-C12alkyl, optionally substituted C1-C12alkyl, optionally substituted C1-C12alkoxy-C1-C12alkyl,optionally substituted C3-C12cycloalkyl, optionally substituted C2-C12alkenyl; optionally substituted C4-C12cycloalkenyl,optionally substituted C2-C12alkynyl; or R2 and R3 together are a three- to seven-membered alkylene or four- to seven-membered alkenylene bridge in each of which a CH2 group may have been replaced by O, S or NR4; X is O or S; R4 is C1-C8alkyl, C3-C8cycloalkyl, C2-C8alkenyl, C2-C8alkynyl, benzyl or C(=O)-R5; R5 is for example H, OH, SH, C1-C12alkyl, C2-C8alkenyl, C2-C8alkynylyl or C1-C12haloalkyl; and, where appropriate, E/Z isomers, mixtures of E/Z isomers and/or tautomers thereof, in each case in free form or in salt form; to a process for the preparation of, and to the use of, such compounds and isomers and tautomers thereof; to starting compounds for the preparation of compounds of formula (I); to pesticidal compositions in which the active ingredient has been selected from the compounds of formula (I) and tautomers thereof; and to a method of controlling pests using such compositions.

    SPIROKETAL DERIVATIVE AND USE THEREOF AS DIABETIC MEDICINE
    8.
    发明公开
    SPIROKETAL DERIVATIVE AND USE THEREOF AS DIABETIC MEDICINE 有权
    SPIROKETAL-DERIVAT UND DESSEN VERWENDUNG ALS DIABETES-HEILMITTEL

    公开(公告)号：EP1852439A1

    公开(公告)日：2007-11-07

    申请号：EP06712450.3

    申请日：2006-01-27

    申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

    发明人： KOBAYASHI, Takamitsu ,  SATO, Tsutomu ,  NISHIMOTO, Masahiro

    IPC分类号： C07H19/01 ,  A61K31/7048 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00

    CPC分类号： C07D311/96 ,  C07D491/153 ,  C07D493/10 ,  C07H19/01

    摘要： The present invention provides a compound of Formula (I):

    wherein R 1 , R 2 , R 3 and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and -C(=O)Rx; Rx represents an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or -NReRf; Ar 1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents -(CH 2 ) m -(L) p - or -(L)p-(CH 2 ) m -; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents -O-, -S- or -NR 5 -; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.

    摘要翻译： 本发明提供式（I）的化合物：其中R 1，R 2，R 3和R 4各自独立地选自氢原子，任选取代的C 1 -C 6烷基，任选取代的C 7 - C 14芳烷基和-C（= O）Rx; Rx表示任选取代的C 1 -C 6烷基，任选取代的芳基，任选取代的杂芳基，任选取代的C 1 -C 6烷氧基或-NReRf; Ar 1表示任选取代的芳族碳环或任选单取代的芳族杂环; Q表示 - （CH 2）m - （L）p - 或 - （L）p-（CH 2）m - ; m表示选自0至2的整数，n表示选自1和2的整数，p表示选自0和1的整数; L表示-O - ， - S-或-NR 5 - ; A表示任选取代的芳基或任选取代的杂芳基，其前药及其药学上可接受的盐以及包含这种化合物的药物组合物或药物组合物。