公开(公告)号：EP4130017B1

公开(公告)日：2025-02-26

申请号：EP20929580.7

申请日：2020-05-11

Inventor： YANG, Chaowen ,  WANG, Lei ,  SONG, Jialiang ,  FU, Dingliang

IPC: C07H19/048 ,  C07H1/00 ,  C07C59/265 ,  C07C59/245 ,  C07C59/42 ,  C07C51/41 ,  A23L33/10 ,  A23L33/175

公开(公告)号：EP4081502B1

公开(公告)日：2025-02-12

申请号：EP20839009.6

申请日：2020-12-21

Inventor： ARAMINI, Andrea ,  BIANCHINI, Gianluca ,  LILLINI, Samuele

IPC: C07C51/41 ,  C07C57/30 ,  A61K31/192 ,  A61P29/00

公开(公告)号：EP4378925A1

公开(公告)日：2024-06-05

申请号：EP21951294.4

申请日：2021-07-29

Applicant: Novocodex Biopharmaceuticals Co., Ltd.

Inventor： YANG, Jinwei ,  YE, Chenghao ,  XIA, Gang ,  HUO, Pengchao ,  DING, Wen ,  CHEN, Longfei ,  JIAO, Lin ,  HUANG, Hao ,  HENG, Xin ,  ZHU, Jingjing ,  YING, Yuebin ,  LIANG, Xuejun

IPC: C07C269/00 ,  C07C269/06 ,  C07C271/22 ,  C07C231/12 ,  C07C235/74 ,  C07D233/56 ,  C07D207/46 ,  C07C51/41 ,  C07C53/18 ,  C07C201/12 ,  C07C205/43 ,  C07C41/16 ,  C07C43/178 ,  C07K14/61 ,  A61K38/27 ,  A61K47/60 ,  A61K47/68 ,  A61P5/06 ,  A61P35/00

CPC classification number: A61K38/27 ,  A61K47/60 ,  A61K47/68 ,  A61P5/06 ,  A61P35/00 ,  C07C41/16 ,  C07C43/178 ,  C07C51/41 ,  C07C53/18 ,  C07C201/12 ,  C07C205/43 ,  C07C231/12 ,  C07C235/74 ,  C07C269/00 ,  C07C269/06 ,  C07C271/22 ,  C07D207/46 ,  C07D233/56 ,  C07K14/61

Abstract: The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,

公开(公告)号：EP4347560A1

公开(公告)日：2024-04-10

申请号：EP22732751.7

申请日：2022-05-24

Applicant: Canna-Chemistries LLC

Inventor： SCHULTHEISS, Nate ,  HOUSTON, Travis Lee ,  PARENT, Stephan D. ,  SETIAWAN, Nico ,  MCCRACKEN, Lisa M. ,  JONAITIS, David

IPC: C07D209/16 ,  C07D213/80 ,  C07C51/41 ,  C07C53/126 ,  C07C55/06 ,  C07C55/14 ,  C07C57/15 ,  C07C59/08 ,  C07C59/255 ,  C07C63/08 ,  A61P25/18 ,  A61K31/4045

公开(公告)号：EP4342900A1

公开(公告)日：2024-03-27

申请号：EP23806780.5

申请日：2023-05-10

Applicant: Tianjin Jikun Medical Technology Co., Ltd.

Inventor： YANG, Cheng ,  YANG, Guang ,  ZHOU, Honggang

IPC: C07D493/10 ,  C07C57/15 ,  C07C51/41 ,  A61K31/365 ,  A61K39/395 ,  A61P35/00

Abstract: The present invention relates to sesquiterpene derivatives represented by formula (I) or pharmaceutically acceptable salts thereof, a pharmaceutical composition comprising the sesquiterpene derivative and a PD-1 antibody as active components, and a preparation method therefor and the use thereof. The sesquiterpene derivatives or the pharmaceutically acceptable salts thereof of the present invention can remarkably enhance the response and treatment effects of a PD-1 antibody to tumors, and combined administration of the sesquiterpene derivatives or the pharmaceutically acceptable salts thereof and the PD-1 antibody presents an obvious synergistic effect and shows extremely strong anti-tumor activity. Therefore, the present invention provides a new way for clinical treatment of tumors and has potential clinical application value and great clinical application prospect.

公开(公告)号：EP4103543B1

公开(公告)日：2023-12-06

申请号：EP21705448.5

申请日：2021-02-10

Inventor： SØNDERGAARD, Kåre

IPC: C07C231/02 ,  C07C231/16 ,  C07C51/487 ,  C07C51/41 ,  C07B53/00

公开(公告)号：EP4244407A1

公开(公告)日：2023-09-20

申请号：EP21805541.6

申请日：2021-11-10

Applicant: Shell Internationale Research Maatschappij B.V.

Inventor： KLEMT, Andreas ,  SCHOLZ, Sven

IPC: C25B1/46 ,  C25B15/08 ,  C07C51/02 ,  C07C51/09 ,  C07C51/41 ,  C07C67/08 ,  C07C53/02 ,  C07C53/06 ,  C07C69/06 ,  C07C55/06

公开(公告)号：EP3983368B1

公开(公告)日：2023-08-02

申请号：EP20730676.2

申请日：2020-06-11

Inventor： TAMMER, Martinus, Catharinus ,  DEN BRABER, Antonie ,  DIRIX, Carolina, Anna, Maria, Christina

IPC: C07C51/083 ,  C07C51/41 ,  C07C51/56 ,  C07C407/00 ,  C07C409/34 ,  C07C53/122 ,  C07C53/124 ,  C07C53/126 ,  C07C53/128

公开(公告)号：EP4077261B1

公开(公告)日：2023-06-07

申请号：EP20825399.7

申请日：2020-12-04

Inventor： HARDIMON, Joseph R. ,  MORRIS, Kasey L.

IPC: C07C51/41 ,  C07C227/16 ,  C07C229/76

公开(公告)号：EP4169900A1

公开(公告)日：2023-04-26

申请号：EP22202907.6

申请日：2022-10-21

Applicant: Commissariat à l'énergie atomique et aux énergies alternatives

Inventor： GOUGET, Valentin

IPC: C07C51/41 ,  C07C63/48 ,  H01M4/13 ,  H01M4/139 ,  H01M4/60

Abstract: La présente invention vise à titre principal un procédé de préparation d'un matériau de type carboxylate de métal alcalin électro-actif, comprenant au moins les étapes consistant à
(i) disposer d'un mélange solide comprenant au moins un composé source en ions alcalins et au moins un composé aromatique polycondensé choisi parmi les (poly)acides carboxyliques aromatiques polycondensés et les (poly)anhydrides d'acide aromatique polycondensé,
(ii) soumettre ledit mélange solide de l'étape (i) à une contrainte mécanique propice à l'interaction mécanochimique desdits composé(s) source en ions alcalins et composé(s) aromatique(s) polycondensé(s) pour former ledit carboxylate de métal alcalin, et
(iii) récupérer ledit matériau de type carboxylate de métal alcalin, notamment par tamisage.