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公开(公告)号：EP4400507A3
公开(公告)日：2024-11-13
申请号：EP24179089.8
申请日：2016-09-08
发明人： Birdsall, Robert
摘要： The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
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公开(公告)号：EP4444738A2
公开(公告)日：2024-10-16
申请号：EP22830832.6
申请日：2022-12-07
申请人： Ferring B.V.
发明人： KAMHI, Eyal , MINTZ, Michelle , AHARONOV, Jenny , EREZ, Elinor
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公开(公告)号：EP4389157A3
公开(公告)日：2024-09-18
申请号：EP23218381.4
申请日：2014-11-13
发明人： FISHER, Susan , CHEN, Qi , NORLING, Lenore
CPC分类号： A61K38/00 , C07K1/14 , C07K1/18 , C07K1/22 , A61L2/0088
摘要： The invention provides for methods of inactivating virus in product feedstream in a manufacturing process of a therapeutic polypeptide using an environmentally compatible detergent. The environmentally compatible detergent does not adversely affect product quality while effectively inactivating virus in the feedstream.
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公开(公告)号：EP4381088A1
公开(公告)日：2024-06-12
申请号：EP22851523.5
申请日：2022-08-05
申请人： Rapid Novor Inc.
发明人： LE BIHAN, Thierry , NUNEZ DE VILLAVICENCIO DIAZ, Teresa , LIYASOVA, Mariya , YAO, Chenyu , LIU, Qixin , REITZEL, Chelsea , DUAN, Jin , TAYLOR, Paul , MA, Bin
IPC分类号： C12Q1/37 , C07K1/14 , C07K1/18 , C07K16/00 , G01N30/02 , G01N30/60 , G01N30/72 , G01N33/53 , G01N33/543
CPC分类号： C07K1/20 , C07K1/24 , C07K1/36 , G01N33/6854 , G01N33/6857 , G01N33/6848 , C07K16/065
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7.发明授权
公开(公告)号：EP3954725B1
公开(公告)日：2024-03-06
申请号：EP20788609.4
申请日：2020-04-07
发明人： TANIGUCHI, Hiroki , HIDAKA, Junji
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公开(公告)号：EP4328233A1
公开(公告)日：2024-02-28
申请号：EP22841955.2
申请日：2022-06-29
申请人： TOPPAN INC. , OSAKA UNIVERSITY
发明人： YAMADA Asuka , KITANO Shiro , MATSUSAKI Michiya
摘要： One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.
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公开(公告)号：EP4317169A1
公开(公告)日：2024-02-07
申请号：EP22774718.5
申请日：2022-02-07
申请人： Kaneka Corporation
摘要： This invention is intended to efficiently extract and purify a target foreign protein expressed with the use of an E. coli strain from the periplasm. This invention provides a method for producing a protein comprising the steps (a) to (c) below: (a) a step of introducing a gene encoding a target foreign protein into E. coli having modification in a gene associated with maintenance of the outer membrane structure; (b) a step of culturing the E. coli of (a); and (c) a step of recovering a target foreign protein from the periplasmic fraction of the microbial cell after culture.
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公开(公告)号：EP4314234A1
公开(公告)日：2024-02-07
申请号：EP22718079.1
申请日：2022-03-21
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