-
公开(公告)号：EP4275717A1
公开(公告)日：2023-11-15
申请号：EP21917770.6
申请日：2021-12-28
申请人： Daicel Corporation
发明人： SAKAGUCHI, Yuko , TERAI, Kazuhiro
摘要： An object of the present disclosure is to provide an injector in which at least when a solution containing a biomolecule is injected into an injection target, a rate of the biomolecule that functions in the injection target is large. The object is achieved by an injector configured to inject a solution containing a biomolecule and a gas that is predetermined into an injection target without using an injection needle, the injector including a storage portion configured to store the solution containing the biomolecule and the gas, a nozzle portion communicating with the storage portion, the nozzle portion including an ejection port configured to eject the solution containing the biomolecule and the gas toward the injection target, and a pressurization portion configured to pressurize the solution containing the biomolecule and the gas that are stored in the storage portion during an operation and to eject the solution containing the biomolecule and the gas from the ejection port toward the injection target.
-
公开(公告)号：EP4105334A1
公开(公告)日：2022-12-21
申请号：EP22757468.8
申请日：2022-01-07
发明人： KUANG, Youyi , ZHENG, Xianhu , TONG, Guangxiang , SUN, Zhipeng , CAO, Dingchen , YAN, Ting , XU, Huan , DONG, Le , YANG, Xiaoxing , LIU, Tianqi , ZHANG, Tan , ZHANG, Tingting , SUN, Xiaowen
IPC分类号： C12N15/89 , C12N15/873 , A01K67/027
摘要： The disclosure provides a method for breeding Carassius auratus strains without intermuscular bones, which relates to aquaculture breeding method. In order to eliminate intermuscular bones in Carassius auratus, a method for breeding strains of Carassius auratus with fewer intermuscular bones or without intermuscular bones by knocking out the bmp6 gene is proposed by the present disclosure. Breeding method: designing knockout target sites for the two copies of the bmp6, bmp6a and bmp6b, in the Carassius auratus genome, and then obtaining F2 generation individuals from a homozygous line with bmp6a and bmp6b double gene mutation through two rounds of gene knockout and screening, and then propagating by using the F2 generation individuals from the homozygous line with bmp6a and bmp6b double gene mutation to form a new Carassius auratus strain with intermuscular bone-deficient. Strains of Carassius auratus with less than 20 intermuscular bones and without intermuscular bones are obtained by the method of the present disclosure.
-
公开(公告)号：EP3823663A1
公开(公告)日：2021-05-26
申请号：EP18927137.2
申请日：2018-07-19
发明人： ZHANG, Yi , INOUE, Azusa
IPC分类号： A61K38/44 , C12N15/873 , C12N15/877 , C12N15/89
-
公开(公告)号：EP3212772A1
公开(公告)日：2017-09-06
申请号：EP15855640.7
申请日：2015-10-30
发明人： SHAREI, Armon, R. , MAO, Shirley , HARTOULAROS, George , LIU, Sophia , HEIMANN, Megan , BASTO, Pamela , SZETO, Gregory , JHUNJHUNWALA, Siddharth , IRVINE, Darrell , LANGER, Robert, S. , JENSEN, Klavs, F. , VON ANDRIAN, Ulrich, H.
CPC分类号： C12M35/04 , A61K39/00 , A61K45/06 , A61K49/0017 , A61K2039/5158 , C12M23/16 , C12M35/00 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N15/87 , C12N2501/05 , C12N2501/998 , C12N2510/00 , C12N2527/00 , G01N33/5047
摘要： A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
摘要翻译： 用于优先将化合物如抗原递送至免疫细胞的胞质溶胶的方法和装置。 该方法包括使包含靶免疫细胞的细胞悬浮液通过微流体装置并使悬浮液与待递送的化合物或有效负荷接触。
-
5.发明公开LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA 审中-公开LIPIDFORMULIERUNGEN ZUR FREISETZUNG VON MESSENGER-RNA
公开(公告)号：EP3060257A1
公开(公告)日：2016-08-31
申请号：EP14792713.1
申请日：2014-10-22
CPC分类号： A61K9/1272 , A61K38/1709 , A61K38/177 , A61K38/4846 , A61K38/53 , A61K48/00 , A61K48/0033 , A61K48/005
摘要： The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明尤其提供了在体内递送mRNA的方法，包括向需要递送的受试者施用包含在脂质体内的编码蛋白质的mRNA的组合物，使得组合物的施用导致表达 由mRNA在体内编码的蛋白质，其中所述脂质体包含式Ic阳离子脂质或其药学上可接受的盐。
-
公开(公告)号：EP2839016A4
公开(公告)日：2015-11-25
申请号：EP13777737
申请日：2013-04-19
发明人： TYACK SCOTT GEOFFREY
IPC分类号： C12N15/90 , A01K67/02 , A01K67/027 , C12N5/16 , C12N15/85 , C12N15/87 , C12N15/873 , C12N15/88 , C12N15/89
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/058 , A01K2227/30 , A01K2267/02 , C12N15/1131 , C12N15/8509 , C12N15/87 , C12N15/873 , C12N15/88 , C12N15/89 , C12N15/902 , C12N2517/02 , C12N2800/90 , C12N2310/14 , C12N2310/531
摘要： The present invention relates to methods for transfecting cells. In particular, the present invention relates to methods of transfecting primordial germ cells in avians, and to methods of breeding avians with modified traits.
-
公开(公告)号：EP2768942A4
公开(公告)日：2015-05-27
申请号：EP12841329
申请日：2012-10-17
发明人： ADAMO ANDREA
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
-
公开(公告)号：EP2768942A1
公开(公告)日：2014-08-27
申请号：EP12841329.1
申请日：2012-10-17
发明人： ADAMO, Andrea
摘要： A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that a cell suspended in a buffer can pass therethrough, wherein the microfluidic channel includes a cell-deforming constriction, wherein a diameter of the constriction is a function of the diameter of the cell.
-
9.发明公开Inoculating apparatus for biological samples in agar surface of petri capsules 审中-公开Inokulationsvorrichtung在陪替氏胶囊的琼脂表面的生物样品
公开(公告)号：EP2522734A3
公开(公告)日：2013-08-28
申请号：EP12167500.3
申请日：2012-05-10
申请人： IUL, S.A.
发明人： Font Castell, Victor
CPC分类号： C12M35/00
摘要： The invention relates to those apparatus that include a disposable microsyringe, whose tubular body is attached by its rear end into the front starting point of a longitudinal void of an intermediate housing, locating in said longitudinal void a moving head movable upon an axis and, which is connected to the rear end of the syringe plunger. It is characterised in that the moving head (9) is also connected, by means of a longitudinal rod (12), to a moving carriage (13) movable upon an axis along the same direction as the moving head (9), and being said moving carriage (13) guided within an elongated tube (8) connected to at the rear end of the intermediate housing (7), as a continuation thereof, incorporating to said elongated tube (8) a motor element, whose actuation drives the plunger (10) by means of a moving head (9), a longitudinal rod (12) and a moving carriage (13).
-
公开(公告)号：EP2367946A4
公开(公告)日：2013-03-13
申请号：EP09827176
申请日：2009-11-17
申请人： GENEFORGE LTD
发明人： HUANG YAOXIONG
IPC分类号： C12N15/87 , B23K26/32 , B23K26/40 , B26F1/31 , B81B1/00 , B82Y5/00 , C12N15/89 , C12N15/90 , G01N21/84
CPC分类号： C12N15/90 , A61K48/00 , B23K26/324 , B23K2203/30 , B23K2203/32 , B23K2203/50 , B82Y5/00
-
-
-
-
-
-
-
-
-
搜索结果
177 条记录 (耗时 0.025 秒)
