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    FEEDER-FREE CULTURE SYSTEM
    8.
    发明公开
    FEEDER-FREE CULTURE SYSTEM 审中-实审

    公开(公告)号：EP4368701A2

    公开(公告)日：2024-05-15

    申请号：EP24152287.9

    申请日：2008-10-20

    申请人： ViaCyte, Inc.

    发明人： ROBINS, Allan, J. ,  SCHULZ, Thomas, C.

    IPC分类号： C12N5/0735

    CPC分类号： C12N2500/9820130101 ,  C12N5/0606

    摘要： The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.

    METHOD FOR PRODUCING CEREBRAL CORTICAL CELL PREPARATION DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
    9.
    发明公开
    METHOD FOR PRODUCING CEREBRAL CORTICAL CELL PREPARATION DERIVED FROM HUMAN PLURIPOTENT STEM CELLS 审中-实审

    公开(公告)号：EP4357449A1

    公开(公告)日：2024-04-24

    申请号：EP22825074.2

    申请日：2022-06-16

    申请人： Kyoto University ,  Sumitomo Pharma Co., Ltd.

    发明人： TAKAHASHI, Jun ,  DOI, Daisuke ,  IKEDA, Megumi

    IPC分类号： C12N5/0735 ,  C12N5/074

    CPC分类号： C12N5/06

    摘要： An object of the present invention is to provide a cerebral organoid derived from a human pluripotent stem cell, a cell aggregate including a cerebral cortical cell, and a method for producing any of them, each being useful for regenerative therapy. The method of the present invention for producing a cerebral organoid is a method for producing a cerebral organoid from a pluripotent stem cell in the absence of a sustentacular cell, and comprises: (1) a step of culturing the pluripotent stem cell in a culture solution, wherein the culture solution is substantially free of bFGF and provokes substantially no TGFβ signal; and (2) a step of inducing the cell obtained in step (1) to differentiate into a neural cell.