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公开(公告)号：EP4378476A1
公开(公告)日：2024-06-05
申请号：EP22849520.6
申请日：2022-07-27
发明人： KUME, Masahiko , OKANO, Fumiyoshi , WASAI, Ukei , SAITO, Takanori
IPC分类号： A61K39/395 , A61K31/4045 , A61K38/07 , A61K45/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K16/28 , C07K16/46 , C12N9/99 , C12N15/13
CPC分类号： A61K31/4045 , A61K38/07 , A61K39/395 , A61K45/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K16/00 , C07K16/28 , C07K16/46 , C12N9/99
摘要： The present invention relates to a medicament for treatment and/or prevention of cancer, comprising an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein, and an HDAC inhibitor together or separately in combination.
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公开(公告)号：EP3677266B1
公开(公告)日：2024-01-17
申请号：EP18851555.5
申请日：2018-08-31
发明人： ABE, Naomi , HASAKO, Shinichi
IPC分类号： A61K31/519 , A61P35/00 , C12N9/99
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3.发明公开
公开(公告)号：EP4260873A1
公开(公告)日：2023-10-18
申请号：EP21906560.4
申请日：2021-12-13
IPC分类号： A61K45/06 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4162 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/522 , A61K31/713 , A61K48/00 , A61P35/00 , A61P43/00 , C12N9/99 , C12N15/11 , C12N15/113
摘要： The present invention relates a combination drug for treating a renal cancer and a potentiator for therapeutic effects of a tyrosine kinase inhibitor. The combination drug includes a combination of a tyrosine kinase inhibitor, and a dipeptidyl peptidase-4 inhibitor. The potentiator includes a dipeptidyl peptidase-4 inhibitor. The potentiator enhances therapeutic effects of a tyrosine kinase inhibitor on a renal cancer.
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公开(公告)号：EP4223786A3
公开(公告)日：2023-08-16
申请号：EP23165932.7
申请日：2016-03-07
申请人： Public University Corporation Yokohama City University , Public University Corporation Nagoya City University , Pharma Foods International Co., Ltd.
发明人： Sato, Mamoru , Yamada, Michiyuki , Kanazawa, Satoshi , Toyoura, Masayoshi , Shoya, Yuji , Saito, Kenji , Yamazaki, Chihiro
摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0 × 10 -9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.
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公开(公告)号：EP3266872B1
公开(公告)日：2023-05-17
申请号：EP16761721.6
申请日：2016-03-07
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公开(公告)号：EP4105319A1
公开(公告)日：2022-12-21
申请号：EP21754008.7
申请日：2021-02-12
申请人： Kaneka Corporation , RIKEN
发明人： TAKEUCHI, Kazuhiro , IBUKI, Masato , HAYASHI, Yohei , TAKASAKI, Mami , KAMBAYASHI, Sho , KAWAI, Yoshikazu
IPC分类号： C12N5/0735 , C12N5/10 , C12N9/99
摘要： Pluripotent stem cells are suspension-cultured with the undifferentiated state thereof maintained. In suspension culture of pluripotent stem cells, the undifferentiated state is maintained by the presence of a PKC inhibitor, especially, a PKCβ inhibitor, and a tankyrase inhibitor (TNKS inhibitor).
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公开(公告)号：EP3816289A1
公开(公告)日：2021-05-05
申请号：EP19823371.0
申请日：2019-06-19
发明人： SAITO, Kenji , SAKATA, Tomoko , KAWANOBE, Takaaki , KOGA, Keita
IPC分类号： C12N15/13 , A61K39/395 , A61P19/02 , C07K7/08 , C07K16/40 , C12N9/99 , C12N15/63 , C12P21/08
摘要： To obtain an anti-PAD2 antibody having excellent PAD2 inhibitory activity. Provided is an anti-PAD2 antibody that specifically binds to positions 341 to 357 of PAD2. Also provided is an anti-PAD2 antibody that specifically binds to a peptide consisting of an amino acid sequence set forth in SEQ ID NO: 1.
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公开(公告)号：EP3677266A1
公开(公告)日：2020-07-08
申请号：EP18851555.5
申请日：2018-08-31
发明人： ABE, Naomi , HASAKO, Shinichi
IPC分类号： A61K31/519 , A61P35/00 , C12N9/99
摘要： An antitumor agent for treating a malignant tumor patient expressing EGFR having at least one mutation selected from the group consisting of G719X mutation of exon 18, E709X mutation of exon 18, and L861X mutation of exon 21, wherein X represents an arbitrary amino-acid residue, the antitumor agent comprising (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl)acrylamide or a salt thereof.
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公开(公告)号：EP3265558B1
公开(公告)日：2020-05-06
申请号：EP16762306.5
申请日：2016-03-07
发明人： GONG, Xiao-Song , WAN, Cindy
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