公开(公告)号：EP3593817B1

公开(公告)日：2024-11-13

申请号：EP18764652.6

申请日：2018-03-06

发明人： IKEDA Shinichi ,  JIANG Xiaoyan ,  TSUBOTA Kazuo ,  KURIHARA Toshihide

IPC分类号： A61K31/7088 ,  A61K45/00 ,  A61K31/575 ,  A61K31/519 ,  A61K31/472 ,  A61K31/4706 ,  A61K31/365 ,  A61K31/192 ,  A61K31/155 ,  G01N33/50 ,  G01N33/15 ,  C12Q1/04 ,  A61P43/00 ,  A61P27/10 ,  A61K31/235

公开(公告)号：EP4058796B1

公开(公告)日：2024-10-23

申请号：EP20811084.1

申请日：2020-11-16

发明人： CORBALLY, Adam Richard ,  EASTWOOD, Ian Michael

IPC分类号： G01N27/48 ,  G01N33/14 ,  G01N33/15 ,  G01N33/22

公开(公告)号：EP4431115A1

公开(公告)日：2024-09-18

申请号：EP23780293.9

申请日：2023-03-27

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： TAKANASHI, Kenji ,  TAKANO, Ryusuke ,  TANIDA, Satoshi ,  NAKAE, Shinichi ,  IIKURA, Hitoshi ,  NISHIMURA, Yoshikazu ,  KURAMOTO, Shino

IPC分类号： A61K47/34 ,  A61K47/44 ,  A61K38/08 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/50 ,  A61K47/44 ,  A61K47/34 ,  A61K38/08 ,  G01N33/15

摘要： The present invention relates to a formulation comprising a compound and an oily component having a polyoxyethylene structure, wherein the content of the oily component having a polyoxyethylene structure is 2.0% by volume or more and 7.5% by volume or less based on 100% by volume of the formulation.

公开(公告)号：EP4400580A1

公开(公告)日：2024-07-17

申请号：EP22867310.9

申请日：2022-09-02

申请人： Nikkiso Co., Ltd.

发明人： TAKAHASHI, Etsushi

IPC分类号： C12N5/077 ,  C12N1/04 ,  C12Q1/02 ,  G01N33/15 ,  A61L27/38 ,  A61K35/22

CPC分类号： A61K35/22 ,  A61L27/38 ,  C12N1/04 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/15

摘要： Provided is a method for storing or transporting renal cells that have a high cell viability, maintain a physiological function of the kidney, and can be used as a drug evaluation system, at a temperature lower than a culture temperature. An aspect of the present invention is a method for storing or transporting renal cells, the method including a maintenance step of managing a liquid containing aggregates of the renal cells to a temperature that is a maintenance temperature and lower than a culture temperature of the renal cells and at which the liquid is not frozen.

公开(公告)号：EP3413045B1

公开(公告)日：2024-04-03

申请号：EP17750223.4

申请日：2017-02-07

发明人： TAKEUCHI Kengo ,  SAKAMOTO Kana ,  KATAYAMA Ryohei ,  SAKATA Seiji

IPC分类号： G01N33/48 ,  C12Q1/6886 ,  A61K31/675 ,  A61K31/635 ,  A61K31/4045 ,  A61K31/167 ,  G01N33/574 ,  G01N33/50 ,  G01N33/15 ,  C12Q1/68 ,  C12Q1/02 ,  A61P35/02 ,  A61K45/00 ,  A61K31/551 ,  A61K31/55 ,  A61K31/517 ,  A61K31/4745 ,  A61P43/00

公开(公告)号：EP4231014A3

公开(公告)日：2024-03-20

申请号：EP23167770.9

申请日：2011-11-30

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： IGAWA, Tomoyuki ,  ISHII, Shinya ,  FUNAKI, Miho ,  HIRONIWA, Naoka ,  MAEDA, Atsuhiko ,  NEZU, Junichi ,  RUIKE, Yoshinao ,  BABA, Takeshi ,  SHIMIZU, Shun

IPC分类号： C12N15/09 ,  A61K39/395 ,  C07K16/18 ,  C07K16/46 ,  C12P21/08 ,  G01N33/15 ,  G01N33/50

摘要： An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

公开(公告)号：EP3248597B1

公开(公告)日：2024-03-13

申请号：EP16740038.1

申请日：2016-01-13

发明人： HOSOYA, Makoto ,  FUJIOKA, Masato ,  OKANO, Hideyuki ,  OGAWA, Kaoru ,  MATSUNAGA, Tatsuo

IPC分类号： A61K31/436 ,  A61K31/155 ,  A61K31/439 ,  G01N33/50 ,  G01N33/15 ,  A61P27/16 ,  A61P43/00

公开(公告)号：EP3663757B1

公开(公告)日：2024-02-21

申请号：EP18841316.5

申请日：2018-07-31

发明人： SHIMMURA, Shigeto ,  HATOU, Shin ,  INAGAKI, Emi ,  TSUBOTA, Kazuo

IPC分类号： G01N33/48 ,  C12N5/09 ,  C12N5/095 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  A61K35/13 ,  A61K35/545 ,  A61P43/00 ,  A01K67/027

公开(公告)号：EP4317452A1

公开(公告)日：2024-02-07

申请号：EP22774634.4

申请日：2022-01-25

申请人： THE NISSHIN OILLIO GROUP, LTD.

发明人： KIMURA Ikuo ,  OHUE Ryuji ,  IGARASHI Miki ,  WATANABE Shinji ,  YAMAUCHI Akiko

IPC分类号： C12Q1/06 ,  A23L33/12 ,  A61K31/20 ,  A61K31/23 ,  A61K45/00 ,  A61P1/18 ,  A61P3/04 ,  A61P3/10 ,  A61P25/28 ,  A61P43/00 ,  G01N33/15 ,  G01N33/50

摘要： The present invention addresses the problem of providing a novel GLP-1 secretion promotion agent. The present invention provides a GLP-1 secretion promotion agent that includes a GPR84 agonist as an active ingredient.

公开(公告)号：EP3591050B1

公开(公告)日：2024-01-31

申请号：EP19186826.4

申请日：2014-09-04

发明人： ABURATANI, Hiroyuki ,  ISHIKAWA, Shumpei ,  KAKIUCHI, Miwako ,  NISHIZAWA, Takashi

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K48/00 ,  A61P35/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574 ,  C12Q1/68 ,  A61K31/713 ,  C12N9/14