公开(公告)号：EP4449120A1

公开(公告)日：2024-10-23

申请号：EP22829829.5

申请日：2022-12-14

申请人： Medicines Discovery Catapult Limited

发明人： MAIN, Martin ,  DAUBNER, Gerrit ,  VINCENT, John ,  BURNHAM, Matthew ,  HART, Philippa Jayne

IPC分类号： G01N33/537 ,  G01N33/539 ,  G01N33/68

公开(公告)号：EP4430398A1

公开(公告)日：2024-09-18

申请号：EP22821819.4

申请日：2022-11-09

申请人： 10X Genomics, Inc.

发明人： MCDONNELL, Wyatt James ,  STUBBINGTON, Michael John Terry ,  MCDERMOTT, Geoffrey P. ,  PATTERSON, David Michael ,  ENGBLOM, Camilla ,  THRANE, Kim ,  MOLD, Jeffrey ,  FRISEN, Jonas ,  LUNDEBERG, Joakim ,  LIN, Qirong ,  GALLANT, Caroline Julie ,  STOECKIUS, Marlon ,  PFEIFFER, Katherine ,  BENT, Zachary ,  GALONSKA, Christina ,  ROYALL, Ariel

IPC分类号： G01N33/537 ,  G01N33/577 ,  G01N33/58 ,  G01N33/68

CPC分类号： G01N33/577 ,  G01N33/585 ,  G01N33/5375 ,  G01N33/6854 ,  G01N33/6857

公开(公告)号：EP4242656A1

公开(公告)日：2023-09-13

申请号：EP22161450.6

申请日：2022-03-10

申请人： Actome GmbH

发明人： Csaba, Jeney

IPC分类号： G01N33/537

摘要： The invention generally suggests a quantitative detection method (1) for a target (2), whereby the target (2), a first probe (3), and a second probe (4) are mixed, wherein the first and second probes (3, 4) bind to the target (2) and wherein a presence of the first probe (3) can be distinguished from a presence of the second probe (4), wherein the mixture (5) of the target (2) and the first and second probes (3, 4) is partitioned in countable compartments (6), wherein a quantity relating to a number of compartments (6), a quantity relating to a number of compartments (6) where at least the first probe (3) is present, a quantity relating to a number of compartments (6) where at least the second probe (4) is present and a quantity relating to a number of compartments (6) where both the first probe (3) and the second probe (4) are present are determined and wherein a quantity relating to a number of compartments (6) that contain the target (2) is determined automatically from the determined quantities (Fig. Fig. 6).

公开(公告)号：EP3859324A1

公开(公告)日：2021-08-04

申请号：EP19874815.4

申请日：2019-10-16

申请人： TERUMO Kabushiki Kaisha

发明人： SATO, Hiroya

IPC分类号： G01N27/447 ,  G01N33/537 ,  G01N33/558

摘要： This disclosure provides a means capable of separating a target substance regardless of types (charge) of the target substance. A separation method for a target substance according to this disclosure includes: forming a target substance-magnetic particle complex using a sample containing a target substance and magnetic particles to which a first receptor that specifically recognizes a site of the target substance is fixed; and separating the target substance-magnetic particle complex by magnetism and electrophoresis.

公开(公告)号：EP3588089A1

公开(公告)日：2020-01-01

申请号：EP19020049.3

申请日：2014-03-03

申请人： Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA

发明人： Castanheira Aires Da Silva, Frederico Nuno ,  Volker Côrte-Real, Sofia ,  Braz Gonçalves, João Manuel ,  Santiago De Oliveira, Soraia Rafaela

IPC分类号： G01N33/537 ,  G01N33/566

摘要： The invention provides cell-based methods for diversifying, expressing and selecting binding molecules, e.g., antibodies, and target molecules to which they bind, all of which are expressed in the same cell. The target molecule can be a member of a ligand binding pair comprising a cell-surface expressed ligand binding receptor molecule and its cognate ligand, which interact within the cell. The methods provide retaining either the antibody or its target in a cell organelle as the site of binding and interaction. By performance of the methods, the binding or non-binding of the antibody to its target molecule within the cell produces a cell phenotype that is detectable at the cell surface via high throughput assays, e.g., flow cytometry. The methods are particularly useful for generating, recovering and providing antibodies that have optimal target molecule binding properties or activities for potential therapeutic use. Methods for generating genetic diversity and increased binding properties for such antibodies are also provided.

公开(公告)号：EP3532851A1

公开(公告)日：2019-09-04

申请号：EP17858959.4

申请日：2017-10-02

申请人： Duke University

发明人： BIGNER, Darell D. ,  CHANDRAMOHAN, Vidyalakshmi ,  GROMEIER, Matthias

IPC分类号： G01N33/574 ,  G01N33/68 ,  G01N33/537

公开(公告)号：EP2340123B1

公开(公告)日：2019-06-26

申请号：EP08801905.4

申请日：2008-09-03

申请人： Sanquin Reagents B.V.

发明人： VAN DER DONK, Eric, Marinus, Maria ,  SPRENGERS, Ferry, Gerardus, Cornelis ,  VAN EIJK, Ronald, Victor, Wilhelmus ,  MELSERT, Roeland

IPC分类号： B01L3/14 ,  G01N33/49 ,  G01N33/50 ,  G01N33/537 ,  G01N33/577 ,  G01N33/80

公开(公告)号：EP3230739A1

公开(公告)日：2017-10-18

申请号：EP15804807.4

申请日：2015-12-04

申请人： F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： FAATZ, Elke ,  GERG, Michael ,  JOSEL, Hans-Peter ,  VOGL, Christian

IPC分类号： G01N33/537 ,  G01N33/541

CPC分类号： G01N33/537 ,  C07K16/26 ,  G01N33/541 ,  G01N33/82

摘要： The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin D3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin D3 and not binding to 25-hydroxyvitamin D.

摘要翻译： 本发明涉及用于测量25-羟基维生素D的体外方法，其中潜在干扰化合物24,25-二羟基维生素D 3被特异性结合24,25-二羟基维生素D 3且不与25-二羟基维生素D 3结合的结合剂封闭。 羟维生素D

公开(公告)号：EP1934211B1

公开(公告)日：2017-01-11

申请号：EP06802829.9

申请日：2006-09-01

申请人： VisEn Medical, Inc.

发明人： NARAYANAN, Narasimhachari ,  GROVES, Kevin ,  PETERSON, Jeffrey, D. ,  RAJOPADHYE, Milind

IPC分类号： C07D419/02 ,  C09B23/02 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D209/14 ,  C09B23/01 ,  C09B23/08 ,  G01N33/533 ,  G01N33/58 ,  G01N33/537 ,  A61K49/00

CPC分类号： C09B23/086 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/083 ,  G01N33/533 ,  G01N33/537 ,  G01N33/582

摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

公开(公告)号：EP2321354B1

公开(公告)日：2016-12-07

申请号：EP10705086.6

申请日：2010-02-22

申请人： ESBATech, an Alcon Biomedical Research Unit LLC

发明人： HULMANN-COTTIER, Valérie ,  URECH, David

IPC分类号： C07K16/28 ,  C12N5/0781 ,  C12N15/13 ,  G01N33/537

摘要： The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.