公开(公告)号：JP3045546B2

公开(公告)日：2000-05-29

申请号：JP52766897

申请日：1997-01-16

IPC分类号： A01G31/00 ,  A01N43/16 ,  A01N63/04 ,  C07D311/36 ,  C12N1/14

摘要： Compositions of an alkali metal formononetinate, particularly potassium and sodium, for stimulating the growth of mycorrhizal fungi which colonize the plant and in turn stimulate growth of the plant. The results are improved over formononetin.

公开(公告)号：JP3009599B2

公开(公告)日：2000-02-14

申请号：JP3659895

申请日：1995-02-24

IPC分类号： A23L1/30 ,  A61K31/35 ,  A61K31/352 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K36/48 ,  A61P19/10 ,  A61P43/00 ,  C07D311/36 ,  C07H17/07

公开(公告)号：JPH11292869A

公开(公告)日：1999-10-26

申请号：JP6045199

申请日：1999-03-08

申请人： ERREGIERRE SPA

发明人： FERRARI MASSIMO

IPC分类号： A61K31/00 ,  A61K31/35 ,  A61K31/352 ,  A61P19/00 ,  A61P19/10 ,  A61P43/00 ,  C07D311/36

摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful in the treatment of osteoporosis by reaction between a specific ketone and ethyl orthoformate under specific conditions in a dimethylformamide solvent in the presence of a morpholine catalyst followed by separating the reaction product by a specific means and then reacting it with an isopropyl halide. SOLUTION: This compound is obtained by the following procedure: (A) in dimethylformamide as solvent, (B) in the presence of morpholine as catalyst, a reaction is carried out between (C) 2,4-dihydroxyphenyl benzyl ketone of formula I and (D) ethyl orthoformate at 115-120 deg.C in the ratio of the weight of the component C to the volume of the component A of

公开(公告)号：JPH11269066A

公开(公告)日：1999-10-05

申请号：JP7210098

申请日：1998-03-20

申请人： KAO CORP

发明人： UMEDA TOMOSHIGE ,  SHIMOTOYOTOME REI ,  OTSUJI KAZUYA

IPC分类号： A23L1/30 ,  A61K31/35 ,  A61K31/352 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P17/00 ,  A61P43/00 ,  C07D311/36 ,  C07H17/07

摘要： PROBLEM TO BE SOLVED: To obtain the subject bleaching agent capable of preventing or recovering the blackening of the skin such as freckle and suntan without necessitating labor and easily attaining skin-bleaching effect by using an isoflavone compound as an active component. SOLUTION: This agent contains an isoflavone compound, e.g. a compound expressed by formula I R is H or hydroxyl; R is H, hydroxyl or a 1-6C alkoxy; R is H or a group of formula II [R is H, CO(CH2 )n R or the like; R is H or COOH; (n) is 1-5]}, especially isoflavone, etc., as an active component. The compounding amount of the isoflavone is 0.002 wt.% and the isoflavone is preferably administered at a daily dose of about 1-120,000 mg for >=10 days for an adult.

公开(公告)号：JPH11228430A

公开(公告)日：1999-08-24

申请号：JP5421398

申请日：1998-02-20

申请人： ASAHI BREWERIES LTD

发明人： MATSUMOTO KAZUHIRO ,  WAGA TOSHIAKI

IPC分类号： C07D311/36 ,  A61K31/35 ,  A61K31/352 ,  A61K36/48 ,  A61P3/04 ,  A61P3/06 ,  A61P43/00 ,  A61K35/78

摘要： PROBLEM TO BE SOLVED: To obtain a lipolysis promoter of natural origin with high safety by including soybean or soybean extract as active ingredient to promote the degradation of fat cells accumulated in vivo and suppress, prevent and improve obesity. SOLUTION: This lipolysis promoter contains soybean or soybean extract (pref. a soybean-derived isoflavone, i.e., daidzein or daidzin) as active ingredient. The above soybean extract is obtained by subjecting soybean to extraction with water or an organic solvent such as methanol, ethanol, isopropyl alcohol, butanol, ethyl acetate or acetone, or mixed solvent thereof, followed by, as necessary, defatting with e.g. diethyl ether, and then by subjecting the component thus afforded to concentration, purification, sterilization, drying and the like, as appropriate.

公开(公告)号：JPH1112265A

公开(公告)日：1999-01-19

申请号：JP17030497

申请日：1997-06-26

申请人： SUMIKA FINE CHEMICALS CO LTD

发明人： IMAMIYA KATSUYUKI ,  KAWAMOTO HIROSHI

IPC分类号： C07D311/36 ,  A61K31/35 ,  A61K31/352 ,  A61P19/10 ,  A61P43/00 ,  B01J27/232 ,  C07B61/00

摘要： PROBLEM TO BE SOLVED: To safely obtain the subject compound useful as a medicine without using isopropyl bromide, by reacting a 7-hydroxyisoflavone (salt) with an isopropyl sulfonate compound. SOLUTION: (A) A 7-hydroxyisofavone (salt) of formula I (R is H, K or Na) is reacted with (B) preferably >=1.1 mols and is methyl, ethyl, phenyl or tolyl) (e.g. isopropyl mathanesulfonate) in the presence of (C) optionally >=1 mol. and =50 deg.C and =80 deg.C and

公开(公告)号：JPH10114653A

公开(公告)日：1998-05-06

申请号：JP28734496

申请日：1996-10-11

申请人： TAISHI FOODS

发明人： YAMAGUCHI MASAYOSHI

IPC分类号： A23L1/30 ,  A23L1/304 ,  A23L11/00 ,  A61K31/35 ,  A61K31/352 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K33/30 ,  A61K35/56 ,  A61P3/00 ,  A61P3/14 ,  A61P19/10 ,  A61P43/00 ,  C07D311/36 ,  C07H17/07 ,  A23L1/20

摘要： PROBLEM TO BE SOLVED: To obtain a composition, having promoting effects on osteogenesis and preventing effects on reduction in bone salt mass, useful for treating and preventing osteoporosis and fracture, etc., and usable for a food or a medicine. SOLUTION: This composition having promoting effects on osteogenesis and preventing effects on reduction in bone salt mass comprises isoflavone as its principal active ingredient. The composition is preferably ingested so as to provide genistin contained in the isoflavone, especially the genistin at >=10 M blood level after the passage of 1hr from the ingestion. Furthermore, zinc is preferably contained at >=10 M blood level together therewith.

公开(公告)号：JPH07267943A

公开(公告)日：1995-10-17

申请号：JP249295

申请日：1995-01-11

申请人： TOYAMA CHEMICAL CO LTD

发明人： TAKANO SHUNTARO ,  YOSHIDA CHOSAKU ,  INABA TAKIHIRO ,  TANAKA KEIICHI ,  TAKENO TAKATSUNE ,  NAGAKI HIDEYOSHI ,  SHIMOTORI TOMOYA ,  MAKINO SHINJI

IPC分类号： C07D311/22 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/41 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07D311/24 ,  C07D311/32 ,  C07D311/36 ,  C07D311/38 ,  C07D311/42 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

摘要： PURPOSE:To provide a new 2,3-dihydro-4H-1-benzopyran-4-one derivative useful as an intermediate for a 4H-1-benzopyran-4-one derivative having excellent anti-inflammatory action, antipyretic analgesic action, antiarthritic action and antiallergic action. CONSTITUTION:This benzopyranone derivative is expressed by formula I [R1 is a (halogen-substituted)lower alkyl, a lower alkenyl or an aryl; R is H, an alkyl or an acyl; R is H, a halogen, cyano, a (substituted)alkyl, etc.; R is H, a halogen, NO2, cyano, carboxyl, etc.; R is a (substituted)phenyl, thionyl, a furyl, etc.; Z is O, S or imino] or its salt, e.g. 2,3-dihydro-7- methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one. The compound of formula I is produced by cyclizing a compound of formula II (R is R ; R is R ) with a condensing agent such as phosphorus pentoxide.

公开(公告)号：JPH0714927B2

公开(公告)日：1995-02-22

申请号：JP8318588

申请日：1988-04-06

IPC分类号： C07H17/07 ,  C07D311/36 ,  C07D311/40

公开(公告)号：JPH0617304B2

公开(公告)日：1994-03-09

申请号：JP15710382

申请日：1982-09-09

申请人： RIKAGAKU KENKYUSHO

发明人： ISONO KYOSHI ,  ASAHI KENICHI

IPC分类号： C07D311/30 ,  A61K31/35 ,  A61K31/352 ,  A61P35/00 ,  C07D311/32 ,  C07D311/36