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    PRODUCTION OF PEPTIDE DERIVATIVE, INTERMEDIATE TO PRODUCE PEPTIDE DERIVATIVE, AND PRODUCTION OF THE INTERMEDIATE
    45.
    发明专利
    PRODUCTION OF PEPTIDE DERIVATIVE, INTERMEDIATE TO PRODUCE PEPTIDE DERIVATIVE, AND PRODUCTION OF THE INTERMEDIATE 失效

    公开(公告)号：JPH11130796A

    公开(公告)日：1999-05-18

    申请号：JP23352898

    申请日：1998-08-05

    申请人： DAICEL CHEM ,  TOKYO TANABE CO

    发明人： KISHIDA TATSU ,  NAKANISHI AKIHIRO ,  KIMURA HITOSHI

    IPC分类号： C07K7/06 ,  C07K7/16

    摘要： PROBLEM TO BE SOLVED: To obtain a peptide derivative, for example, for the prevention of premature miscarriage, which has the low anti-vasopressin action but the anti-oxytocin action, by removing protecting groups of a specific peptide having a plurality of protected SH groups, followed by the oxidation in an acidic aqueous medium. SOLUTION: The peptide derivative (or its salt) shown by formula VII is obtained by the first dehydration condensation between a compound shown by formula I (R is H or a protecting group for the guanidino group of Arg; R is a protecting group for the imino group of Pro) and a compound shown by formula II (R is a protecting group for the thiol group; R is a protecting group for the amino group), the second dehydration condensation with a compound shown by formula III (R is a protecting group for the amino group), the third dehydration condensation with a compound shown by formula IV (R is H or a protecting group for the indolyl group; R is the same as R ), the fourth dehydration condensation with a compound shown by formula V to give a compound shown by formula VI (MBzl is 4-methoxybenzyl), the removal of two MBzl groups, followed by the oxidation in an aqueous medium at pH 4.0-6.0 to form the intramolecular disulfide bond(s).

    50.
    发明专利
    失效

    公开(公告)号：JPH0720882B2

    公开(公告)日：1995-03-08

    申请号：JP4162383

    申请日：1983-03-15

    IPC分类号： C07K17/02 ,  A61K38/14 ,  A61K39/385 ,  C07H15/20 ,  C07K7/16 ,  C07K7/23 ,  C07K9/00 ,  C07K14/575 ,  C07K14/655 ,  C07K19/00

    摘要： The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, essentially in the absence of supporting macromolecules, this conjugate having an immunogenic effect not only against itself, but also with respect to the native antigen carrying said antigenic site.