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    SUPPRESSOR FOR CARCINO METASTASIS OR RELAPSE
    62.
    发明专利
    SUPPRESSOR FOR CARCINO METASTASIS OR RELAPSE 失效

    公开(公告)号：JPH1081631A

    公开(公告)日：1998-03-31

    申请号：JP19122097

    申请日：1997-07-16

    申请人： TAKEDA CHEMICAL INDUSTRIES LTD

    发明人： SUDO KATSUICHI ,  HOUGAN KOUJI

    IPC分类号： C07D303/16 ,  A61K31/28 ,  A61K31/335 ,  A61K31/336 ,  A61K31/505 ,  A61K31/675 ,  A61K31/70 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C07D303/18

    摘要： PROBLEM TO BE SOLVED: To obtain the subject pharmaceutical preparation comprising a substance having mild arterialization-inhibiting action usable for a long period and useful for preventing metastasis and relapse of cancer. SOLUTION: This pharmaceutical preparation comprises a substance having preventing action on arterialization, e.g. a fumagiol derivative represented by the formula (R is a hydrocarbon; R is a hydrocarbon or an acyl) or its salt. The fumagiol derivative or its salt is produced as a pharmaceutically permissible acid addition salt when the compound of the formula contains a basic salt and it is produced as a salt with similar base when the compound of the formula contain an acidic group. The compound of the formula is effective in treating and preventing various kinds of diseases such as tumor and the active amount is usually about 0.1-100wt.% based on total amount of preparation. The preparation is prepared in a tablet, fine particles, etc., according to an ordinary method.

    PURIFICATION OF 3,4-EPOXYCYCLOHEXYLMETHYL (METH)ACRYLATE
    67.
    发明专利
    PURIFICATION OF 3,4-EPOXYCYCLOHEXYLMETHYL (METH)ACRYLATE 失效

    公开(公告)号：JPH0967308A

    公开(公告)日：1997-03-11

    申请号：JP24845395

    申请日：1995-09-01

    申请人： DAICEL CHEM

    发明人： OOYAMA KIYUUICHI

    IPC分类号： C07D301/32 ,  C07C67/29 ,  C07C67/54 ,  C07C67/58 ,  C07C69/54 ,  C07D303/16

    摘要： PROBLEM TO BE SOLVED: To simply and effectively purify the subject compound into a compound excellent in coloring preventing effect, useful as a raw material for a resin for a coating material, by treating a crude reaction solution prepared by epoxidizing cyclohexenylmethyl (meth)acrylate with an alkali to reduce a low-boiling component. SOLUTION: A compound of formula I (R is H or methyl) is epoxidized with an organic acid such as performic acid, peracetic acid, etc., to give a crude reaction solution containing a compound of formula II. The crude reaction solution is washed with water and treated with an alkali such as 0.1-10% aqueous solution of sodium hydroxide or sodium (hydrogen)carbonate, decompressed at 30-100 deg.C by a flashing pipe, etc., to make 3-50wt.% low-boiling component content. The solution is then washed with an aqueous solution of an alkali (washing with an aqueous solution of an alkali by a mixer settler) and the boiling component content is reduced by a flashing pipe, etc., at 300-100 deg.C under reduced pressure of