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公开(公告)号：JPH07308197A
公开(公告)日：1995-11-28
申请号：JP10421294
申请日：1994-05-18
Applicant: MITSUI PETROCHEMICAL IND
Inventor： YUKIMUNE TAKAHITO , HARA YASUHIRO
Abstract: PURPOSE:To industrially and advantageously obtain the subject compound useful as a therapeutic agent for ovarian carcinoma, mastocarcinoma, lung cancer, etc., by culturing a cell or a tissue of a plant capable of producing a taxane type terpene in the presence of a specific jasmonic acid and recovering a formed product from the culture mixture. CONSTITUTION:A cell or a tissue of a plant (e.g. Taxus baccata) capable of producing taxane type terpene is cultured in the presence of a jasmonic acid of formula I {R is a 1-4C alkyl, a group of formula II [R is OH, an OM (M is an alkali metal, an alkaline earth metal or NH4), an NHR (R is a 1-4C acyl, a 1-4C alkyl or amino acid) or an OR (R is a 1-4C alkyl or a hydrocarbon residue; (n) is an integer of 1-7]; R to R are each H or R and R , R and R or R and R may form a double bond together; the five-membered ring may be further substituted with a hydroxyl group and may form a double bond between adjoining carbon atoms} and a formed product is recovered to give the abjective taxane type terpene (e.g. taxol).
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Patent Agency Ranking
公开(公告)号：JPH07135967A
公开(公告)日：1995-05-30
申请号：JP28489393
申请日：1993-11-15
Applicant: MITSUI PETROCHEMICAL IND
Inventor： YUKIMUNE TAKAHITO , AZUMA YASUSUKE , ONISHI NAOTO , TABATA HOMARE
Abstract: PURPOSE:To easily obtain cultured cell having high productivity of taxane-type diterpene by fractionating cultured cells of a plant capable of producing taxane- type diterpene taking advantage of specific gravity difference, culturing the fractionated cell and selecting cells having high productivity of taxane-type diterpene from the cultured cells. CONSTITUTION:Cultured cells of a plant capable of producing taxane-type diterpene (e.g. plant of the genus Taxus) are separated into plural groups taking advantage of specific gravity difference in the specific gravity range of usually 1.00-1.20g/mL, preferably 1.03-1.11g/mL. Cells included in at least one group (usually having a specific gravity of
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公开(公告)号：JPH0717649B2
公开(公告)日：1995-03-01
申请号：JP4532990
申请日：1990-02-26
IPC: A23K20/195 , A61K31/35 , A61K35/74 , A61P3/00 , A61P31/04 , A61P33/02 , C07D493/10 , C12N1/20 , C12P17/02 , C12P17/06 , C12P17/18 , C12R1/465 , A23K1/17
Abstract: An antibiotic, prepared by fermentation of Streptomyces sp. ATCC 53862, of the formula:- wherein Me=CH3 and Pr=CH3CH2CH2, or a pharmaceutically acceptable cationic salt thereof. The antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
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公开(公告)号：JPH0751078A
公开(公告)日：1995-02-28
申请号：JP13041094
申请日：1994-06-13
Applicant: BRISTOL MYERS SQUIBB CO
Inventor： RONARUDO ERU HANSON , RAMESHIYU ENU PATERU , RAZURO JIEI ZARUKA
Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.
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公开(公告)号：JPH0710856A
公开(公告)日：1995-01-13
申请号：JP8173794
申请日：1994-04-20
Applicant: SANKYO CO
Inventor： SATOU AIYA , SUGANO MICHIHIRO , IIJIMA YASUTERU , FURUYA KOHEI , SAITO KAZUKO
IPC: A61K31/335 , A61K31/336 , A61K31/425 , A61P7/02 , C07D303/14 , C07D303/16 , C07D303/22 , C07D303/32 , C07D303/48 , C07D405/12 , C07D407/12 , C07D413/12 , C07D417/12 , C12P17/02 , C12R1/645
Abstract: PURPOSE:To obtain a new specific phomactin derivative, which is useful as an antithrombotic agent and for prophylaxis and therapy of asthma, digestive ulcer, nephritic disorders and hypertension because of its platelet activation factor(PAF)-antagonistic action. CONSTITUTION:A strain separated from the shell of a crab (Chinecetes opilio), Phomas sp. SANK 15692 strain (FERM-BP-4175) is inoculated into a culture medium and cultured at 23 deg. in a rotatory shaking inclubator for 7 days. Then, the cultured medium is cultured in a jar fermenter at 23 deg. for 3 days, and further in a tank at 23 deg. for 12 days. The cultured liquid is mixed with ethyl acetate and filtered and the resultant crystals are recrystallized to give phomactin C of the formula I. The product is reduced with lithium aluminum hydride or the like, when needed, and the hydroxy group formed is esterified to give the objective phomactin derivative of the formula II [X is CHO, CH2OH, CH2 OOOR (R is an alkyl, aryl); A, B are each H or together form a single bond; Y is CO, CHOH].
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公开(公告)号：JPH0690772A
公开(公告)日：1994-04-05
申请号：JP8558993
申请日：1993-03-18
Applicant: FRITZSCHE DODGE & OLCOTT INC
Inventor： MOHAMADO AI FUAABUDO , BURAIAN JIEI UIRISU
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