公开(公告)号：JPH05297376A

公开(公告)日：1993-11-12

申请号：JP14473592

申请日：1992-04-20

Applicant: HOECHST JAPAN

Inventor： HARADA TAKAMASA ,  KURAUSU ETSUSHIYAA ,  GERUTO IRIAN ,  ANKE KARUTOBAITSUERU ,  NORUBERUTO REESHIYU

IPC: C09K19/02 ,  G02F1/1337 ,  G02F1/141

Abstract: PURPOSE:To provide the liquid display element which contains an FLC mixture exhibiting high spontaneous polarization in order to shorten the switching time, is drastically decreased in a surface memory effect and exhibits an excellent contrast. CONSTITUTION:The ferroelectric liquid crystal mixture of the ferroelectric liquid crystal display having outside substrates, at least one sheet of which are transparent, electrodes, at least one of which are transparent, polarizers, the ferroelectric liquid crystal mixture and oriented films has the spontaneous polarization of>20nCNUcm Ps and the natural spiral pitch smaller than half of the thickness of the layer and contains at least one kind of a lipophiling compd., lipophilic compd. or amphipathic compd.

公开(公告)号：JPH05247071A

公开(公告)日：1993-09-24

申请号：JP4935292

申请日：1992-03-06

Applicant: HOECHST JAPAN

Inventor： SUGIOKA TATSUO

IPC: A01N57/20 ,  A61K31/66 ,  A61P3/00 ,  A61P43/00 ,  B01J23/02 ,  C07F9/38

Abstract: PURPOSE:To obtain the subject compound useful as pharmaceuticals, agricultural chemicals, etc., in an easily purifiable state in high yield and purity by reacting a specific methylene bisphosphonic acid derivative with an azide derivative in an inert organic solvent in the presence of an alkali metal hydride. CONSTITUTION:The objective compound of formula II can be produced by reacting a methylenebisphosphonic acid derivative of formula I (R is organic residue) with an azide derivative such as tosyl azide in an inert organic solvent (e.g. THF) in the presence of an alkali metal hydride (e.g. lithium hydride) or an alkali metal alkyl compound (e.g. methyllithium).

公开(公告)号：JPH05230044A

公开(公告)日：1993-09-07

申请号：JP7006892

申请日：1992-02-21

Applicant: HOECHST JAPAN

Inventor： MATSUDA YOSHIHISA ,  OTSUKA MAKOTO ,  CHIKARAISHI YUJI

IPC: A61K31/40 ,  A61P7/10 ,  C07D295/14

Abstract: PURPOSE:To provide polymorphic piretanide which is useful as a diuretic agent characterized by the differential thermal curve, powder X-ray analysis and infrared spectroscopy. CONSTITUTION:The piretanide has the endothermic peak at about 213 deg.C, the exothermic peak at about 216 deg.C and the melting peak about 227 deg.C in the differential thermal curve; 20.1, 21.3, 23.1, 24.3 deg. of 2theta diffraction peaks in powder X-ray diffraction and absorptions at 1690 and 3250 to 3400cm in the infrared absorption spectroscopy. The piretanide is obtained by crystallizing lower aliphatic alcohol or cyclic ether to form the solvation bonds and heating them at room temperature to the boiling point of the solvent under reduced or normal pressure for over 1 hour. It is stable at elevated temperatures in high humidity, high soluble in water and shows high bioavailability.

公开(公告)号：JPH05158044A

公开(公告)日：1993-06-25

申请号：JP32433491

申请日：1991-12-09

Applicant: HOECHST JAPAN

Inventor： NOZAWA FUMIE ,  UBUKATA MASAMI

IPC: C09K19/02 ,  C09K19/38 ,  G02F1/1337

Abstract: PURPOSE:To obtain a high-contrast and grade liq. crystal display element by using a polyester having a specified repeating unit as the oriented film material on the opposed faces of substrates CONSTITUTION:A polyester having a repeating unit shown by formulas I, II and III is used as the oriented film material on the opposed faces of the substrates. In formula I, (m) is an integer of 0 to 20, Ar is a bivalent aryl group including an aromatic ring, and the aromatic ring may have >=1 substituent selected from a group consisting of 1-12C alkoxy group, halogens, etc. In formula II, X is Ar (the same as or different from Ar) or (CH2)n, and (n) is an integer of 1 to 10. In formula III, Y is Ar (the same or different from Ar or Ar ) or (CH2)p, and (p) is an integer of 1 to 20.

公开(公告)号：JPH04218018A

公开(公告)日：1992-08-07

申请号：JP7534591

申请日：1991-04-08

Applicant: HOECHST JAPAN

Inventor： HARADA TAKAMASA ,  KURAUSU ETSUSHIYAA ,  GEEAHARUTO IRIAN ,  DEIITAA OORENDORUFU ,  HAINTSU RIIGAA ,  NORUBERUTO REESHIYU

IPC: C09K19/54 ,  C09K19/58 ,  G02F1/13 ,  G02F1/1339 ,  G02F1/1341

Abstract: PURPOSE:To obtain good display characteristics by filling a ferrodielelctric liquid crystal composition containing additives lower in boiling point than the substance exhibiting liquid crystal property into cells at high temperature and in high vacuum and under the other specified conditions. CONSTITUTION:An ultraviolet ray hardenable epoxy resin is printed on the circumference of a orienting film formed on a substrate 1 provided with a transparent electrode and the film to form a sealing part 2. Then, the ferrodielectric liquid crystal composition layer 3 containing a spacer made of silica is formed by coating. This substrate 1 is placed in a vacuum chamber to remove the air out of the composition, and taken out of the chamber, and heated to convert it into an isotropic liquid or a nematic phase and to smooth the surface of the liquid composition crystals. Next, the other side of the substrate 4 opposite to the substrate 1 and provided with no sealing print and not coated with no liquid crystal composition is applied to pressure in vacuum to attain a desired cell gap to form the cells, thus permitting nonuniform adsorption of the low boiling point additives to the orienting film to be prevented.

公开(公告)号：JPH04199715A

公开(公告)日：1992-07-20

申请号：JP33260790

申请日：1990-11-29

Applicant: HITACHI LTD ,  DAICEL CHEM ,  HOECHST JAPAN

Inventor： NIIMURA YOSHIAKI ,  YAMAMOTO MASASHI ,  HONDA ZENJIRO ,  MIHARA KAZUO ,  SHIRAI HIDEKI

IPC: H01L21/304

Abstract: PURPOSE:To prevent the occurrence of water marks by setting up a pervaporation film module in the IPA vapor drying system and separating and removing the water content in the IPA using the pervaporation film module. CONSTITUTION:A pervaporation film module 13 is set up in an isopropyl alcohol IPA vapor drying system 1 and the water content in the IPA 4 is separated and removed using the pervaporation film module 13. The pervaporation film module 13 can for example be a hollow film module, a spiral wound film module, a planar single-layer film module, or a planar compound film module. As a result, the creation of water marks on the wafer 11 surface after drying treatment can be prevented.

公开(公告)号：JPH04171025A

公开(公告)日：1992-06-18

申请号：JP29792290

申请日：1990-11-02

Applicant: DAICEL CHEM ,  HITACHI LTD ,  HOECHST JAPAN

Inventor： HONDA ZENJIRO ,  MIHARA KAZUO ,  NIIMURA YOSHIAKI ,  YAMAMOTO MASASHI ,  SAKURAI TOSHIHIKO ,  SHIRAI HIDEKI

IPC: B01D61/36 ,  B01D12/00 ,  H01L21/304

Abstract: PURPOSE:To make the size of a solvent reproducing apparatus small by directly immersing a part of or the whole pervaporation membrane module in an organic solvent evaporation tank at the time of installation of the solvent reproducing apparatus using the module in the evaporation tank. CONSTITUTION:The pervaporation method is a method not to apply pressure to the raw liquid side but depressurize the permeated side to remove water. Consequently, since pressure for permeation is not needed in the raw liquid side, water in the solvent in the evaporation tank 3 is removed when a PV membrane module 9 is immersed directly in an evaporation tank 3 and the permeated side of the PV membrane module 9 is depressurized. In other words, the PV membrane module 9 is immersed in the evaporation tank 3 in an organic solvent reproducing apparatus consisting of a solvent supplying pipe 1, a solvent 2 the evaporation tank 3, a heater 4, a cooler 5, an object 6 to be cleaned, a vacuum pump suction pipe 11, a condenser 12, a cooling water pipe 13, and a vacuum pump 15. As the result, the whole size of the apparatus is necessarily made small.

公开(公告)号：JPH04117398A

公开(公告)日：1992-04-17

申请号：JP25681090

申请日：1990-09-28

Applicant: HOECHST JAPAN

Inventor： HASHIMOTO TAMOTSU ,  TEZUKA KENICHI ,  KUMEGAWA MASAYOSHI ,  TAKESHITA ATSUSHI

IPC: C12N15/09 ,  A61K20060101 ,  C07K14/52 ,  C12N20060101 ,  C12N15/18 ,  C12P21/02 ,  C12R1/91

Abstract: NEW MATERIAL:A protein having all of an amino acid sequence expressed by the formula, all of the partially modified amino acid sequence or part thereof. USE:A remedy for osteoporosis and dementia. PREPARATION:For example, total RNA is collected from a mouse osteoblast cell-like cell strain MC3TE1 cell by the guanidine method and mRNA is separated using a mRNA purification reagent and cDNA is synthesized using the mRNA as a template and cDNA library is prepared by the ordinary method and the cDNA library is screened by plaque hybridization method using a probe to select a clone containing DNA coding a protein having cell differentiation- forming ability and DNA is recovered from the clone and subjected to restriction enzyme treatment and bound to a vector and introduced into an animal cell to transform the DNA and the transformer is cultured to provide the protein containing an amino acid sequence expressed by the formula.

公开(公告)号：JPH03240738A

公开(公告)日：1991-10-28

申请号：JP3728490

申请日：1990-02-20

Applicant: HOECHST JAPAN

Inventor： KANO MASAHIKO ,  TANAKA SATOSHI ,  IKEDA MASAO ,  NIN HIROSHI

IPC: A61K38/43 ,  A61K38/00 ,  A61L2/00 ,  A61P3/08 ,  A61P3/10 ,  A61P17/00 ,  A61P43/00 ,  C12N9/10

Abstract: PURPOSE:To obtain the subject remedy, containing human blood coagulation factor VIII prepared from a human placenta or blood plasma as an active ingredient and having high effects from an early stage of starting treatment. CONSTITUTION:The subject remedy containing human blood coagulation factor VIII as an active ingredient is produced and administered as an injection, parenterally administered by a microencapsulating or embedding method, orally administered as a solution, tablet or capsule or administered as a suppository, ointment, etc., to treat diabetic necrosis. The factor VIII fulfills a great role in a treating process of wounds by not only stabilizing fibrin but also forming crosslinkages between the fibrin and fibronectin and promoting proliferation of fibroblasts and epidermization. The remedy is administered in an amount of about 1500 units per day to patients suffering from diabetic necrosis for 5 days.

公开(公告)号：JPH02264863A

公开(公告)日：1990-10-29

申请号：JP8489589

申请日：1989-04-05

Applicant: HOECHST JAPAN

Inventor： USUI JUNKO ,  TONE YUKIKO ,  KITAMURA KAZUYUKI ,  WATANABE HIROSHI

IPC: G01N33/564 ,  A61K39/395 ,  C07K1/22 ,  C07K14/00 ,  C07K16/00 ,  C07K19/00 ,  C12P21/08 ,  C07K15/12 ,  C07K15/28

Abstract: PURPOSE:To supply an antibody conjugate of definite quality by bonding an Fc segment of human immunoglobulin and an antibody of a mammal other than a human being having specificity to a human autoantigen by a chemical crosslinking reagent through a covalent bond. CONSTITUTION:An Fc segment of human immunoglobulin as a positive control and an antibody of a mammal other than a human being having specificity to a human autoantigen are bonded by a chemical crosslinking reagent through a covalent bond. As the Fc segment of human immunoglobulin, a commercial Fc segment can be used. As the antibody of a mammal having specificity to the human autoantigen, an antibody obtained from a rabbit, a goat or a mouse can be used. Further, as the chemical crosslinking reagent, an amino group or thiol group of a potein molecule can be used.