Abstract:
PROBLEM TO BE SOLVED: To provide a water-insoluble mixed metal compound below.SOLUTION: The compound includes (i) a solid water-insoluble mixed metal compound capable of bonding phosphate, represented by the chemical formula (I) in an amount of at least 50 wt.% per weight of a granular substance: M-xMx(OH)Ay.zHO (I) [in the formula, Mis at least one kind of magnesium, calcium, lanthanum and cerium; Mis at least iron (III); A-is at least one kind of n-valent anions; x=Σny; 0
Abstract translation:要解决的问题:提供下面的不溶于水的混合金属化合物。溶液:该化合物包括(i)以化学式(I)表示的能够结合磷酸盐的固体水不溶性混合金属化合物,其量为 至少50重量%的颗粒物质:M-xMx(OH)Ay.zHO(I)[在该式中,Mis至少一种镁,钙,镧和铈; 至少铁(III); A是至少一种n价阴离子; X =&的Sgr; NY; 0
Abstract:
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition or a pharmaceutical product containing the composition for the prevention and the treatment of hyperphosphataemia.SOLUTION: A substance for use as a medicament, comprises a solid mixed metal compound of formula (I): MMOA.zHO (I) where Mis at least one bivalent metal: Mis at least one trivalent metal; Ais at least one n-valent anion; 2+a=2b+Σcn; and Σcn
Abstract:
A substance for use as a medicament, comprises a solid mixed metal compound of formula (I): M II 1-a M III a O b A n- c .zH 2 O (I) where M II is at least one bivalent metal: M III bis at least one trivalent metal; A n- is at least one n-valent anion; 2+a=2b+Sigmacn; and Sigmacn II 1-x M III x (OH) 2 A n- y .mH 2 O (II) where M II is at least one bivalent metal; M III is at least one trivalent metal; A n- is at least one n-valent anion; x=Sigmayn 0
Abstract:
A mixed metal compound for pharmaceutical use is free from aluminium and has a phosphate binding capacity of at least 30 %, by weight of the total weight of phosphate present, over a pH range of from 2-8. The compound is especially useful for treatment of hyperphosphataemia. The metals are preferably iron (III) and at least one of calcium, magnesium, lanthanum and cerium. A metal sulphate for pharmaceutical use is selected from at least one of calcium, lanthanum and cerium sulphate compounds and has a phosphate binding capacity of at least 30 % by weight of the total phosphate present, over a pH range from 2-8.
Abstract:
PROBLEM TO BE SOLVED: To provide mixed metal compounds having pharmaceutical activity, especially as phosphate binders; methods of manufacture of those compounds; pharmaceutical compositions containing such compounds; and their pharmaceutical use.SOLUTION: The present invention relates to use of compounds of the formula (I) defined as MM, where Mis at least one bivalent metal (i.e., with two positive charges); Mis at least one trivalent metal (i.e., with three positive charges); and 1>a>0.4.
Abstract translation:要解决的问题:提供具有药物活性的混合金属化合物,特别是作为磷酸盐粘合剂; 制造这些化合物的方法; 含有这些化合物的药物组合物; 及其药物用途。解决方案:本发明涉及定义为MM的式(I)化合物的用途,其中Mis至少一种二价金属(即具有两个正电荷); 至少一种三价金属(即三种正电荷); 和1> a> 0.4。
Abstract:
There is provided a granular material comprising (i) at least 50% by weight based on the weight of the granular material of solid water-insoluble mixed metal compound capable of binding phosphate of formula (I): MII1-xMIIIx(OH)2An-y.ZH2O (I) where MII is at least one of magnesium, calcium, lanthanum and cerium; MIII is at least iron(III); An- is at least one n-valent anion; x=&Sgr;ny; 0