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    VACCINE COMPOSITION FOR MAMMAL
    1.
    发明专利
    VACCINE COMPOSITION FOR MAMMAL 失效

    公开(公告)号：JPH08325163A

    公开(公告)日：1996-12-10

    申请号：JP12143896

    申请日：1996-05-16

    Applicant: AMERICAN HOME PROD ,  AMERICAN HOME PROD

    Inventor： HJORTH RICHARD NORMAN ,  RICHIYAADO NOOMAN HIYORUSU

    IPC: A61K47/02 ,  A61K39/145 ,  A61K39/39 ,  A61K47/06 ,  A61K47/10 ,  A61K47/34

    Abstract: PROBLEM TO BE SOLVED: To provide a novel adjuvant that is useful for increasing the antigen of vaccine for mammalians and vaccine composition containing the same. SOLUTION: This vaccine for mammalian comprises an inactivated whole vaccine or sub-unit vaccine and an effective amount of adjuvant where the adjuvant contains about 1-40 vol.% of squalene, 5-40 vol.% of glycerol and about 0.1-4.0 vol.% of a surfactant based on the whole composition. This composition contains, as desired, an aluminum salt and one or more kinds of pharmaceutically acceptable buffer solution.

    PROTECTIVE FOR NERVE
    5.
    发明专利
    PROTECTIVE FOR NERVE 失效

    公开(公告)号：JPH09183727A

    公开(公告)日：1997-07-15

    申请号：JP32658296

    申请日：1996-12-06

    Applicant: AMERICAN HOME PROD

    Inventor： SUTEIIBUN SHIISUN RIN ,  KIYASARIN RUU MORUNAA KINBAA

    IPC: C07D498/18 ,  A61K31/395 ,  A61K31/435 ,  A61K31/436 ,  A61K31/445 ,  A61K45/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  C07D498/22

    Abstract: PROBLEM TO BE SOLVED: To obtain a pharmaceutical composition capable of inhibiting the death of a mammalian neuronal cell and useful as a nerve protective for treating stroke, head injury and neurodegeneration trouble by compounding a compound selected from rapamycin and its specific derivatives. SOLUTION: This pharmaceutical composition contains a compound selected from among rapamycin, 1,3-Diels-Alder adduct of rapamycin with phenyltriazolinedione, rapamycin 42-ester with 4- [4-(dimethylamino) phenyl]azo}benzenesulfonic acid, 1,3-Diels-Alder adduct of rapamycin with methyltriazolinedione and rapamycin-O-benzyl-27-oxime. When the compound is intravenously administered, the daily dose is preferably 0.01-5mg/kg. In the case of oral administration, the daily dose is preferably 0.05-10mg/kg. Further, the combined use of an antagonistic drug against N-methyl-D-aspartic acid salt preferably enhances nerve protective function.

    PACKAGE FOR VETERINARY IMPLANT
    7.
    发明专利
    PACKAGE FOR VETERINARY IMPLANT 失效

    公开(公告)号：JPH08206176A

    公开(公告)日：1996-08-13

    申请号：JP27589495

    申请日：1995-10-24

    Applicant: AMERICAN HOME PROD

    Inventor： YUNNCHIYUN RII ,  ANDORIYUU RICHIYAADO MIKUZUTAR ,  MIN RON RII ,  SHIYARUDA CHIYAUDORII ,  ROBIN TAFUII ASHIYU

    IPC: A61J1/00 ,  A61K31/565 ,  A61P43/00 ,  B65D81/20

    Abstract: PROBLEM TO BE SOLVED: To provide a stable implant product over a long period of time at a room temperature by surrounding a trenbolone-containing veterinary implant with a seal shielding container to fill the seal container with an inert gas. SOLUTION: A trenbolone-containing veterinary implant is surrounded by a seal shielding container, which is filled with an inert gas to make a package for the trenbolone-containing veterinary implant. The implant herein used contains trenbolone accetate or the material of the implant is selected from a group of trenbone accetate, trenbolone accetate/estradiol and trenbolone accetate/estradiol benzoate. The implant is housed into a magazine and the container should be a pouch. The pouch is constituted of a boil laminate comprising at least one metal foil layer and at least one polymer layer.

    MEDICINAL COMPOSITION CONTAINING VENLAFAXINE FOR INDUCING COGNITION ENHANCEMENT
    9.
    发明专利
    MEDICINAL COMPOSITION CONTAINING VENLAFAXINE FOR INDUCING COGNITION ENHANCEMENT 失效

    公开(公告)号：JPH07252143A

    公开(公告)日：1995-10-03

    申请号：JP2383795

    申请日：1995-02-13

    Applicant: AMERICAN HOME PROD

    Inventor： JIYOOJI EDOWAADO MORISU HAZUBA ,  MAJITSUDO ABUDERUUMEJITSUDO AB ,  JIYON AREN MOIYAA ,  ERITSUKU ANSONII MASU

    IPC: A61K31/135 ,  A61P25/28

    Abstract: PURPOSE: To obtain a pharmaceutical composition containing venlafaxine and useful for treating cognition impairment. CONSTITUTION: This pharmaceutical composition contains a compound of formula I A is a group of formula II [the dotted line expresses, if necessary, an unsaturated bond; R4 is H, a 1-6C alkyl, etc.; (n) is 0-4]; R1 is H, a 1-6C alkyl; R2 is a 1-6C alkyl; R5 , R6 are each H, hydroxyl, a 1-6C alkyl, a 1-6C alkoxy, cyano, etc.; R7 is H, a 1-6C alkyl} or its salt, e.g. 1-[(2-dimethylamino)-1-(4- methoxyphenyl)ethyl]cyclohexanol (venlafaxine), as an active ingredient. The pharmaceutical composition can be prepared in the form of an oral administration preparation or a parenteral administration preparation, and is administered at a daily dose of 50-375 mg. The pharmaceutical composition is useful for treating cognition impairments caused by dementia, senile dementia of Alzheimer type, Parkinson's disease, memory disorder accompanied by aging, etc.

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