公开(公告)号：JP2008297220A

公开(公告)日：2008-12-11

申请号：JP2007142412

申请日：2007-05-29

申请人： Metabolome Pharmaceuticals Inc ,  Saitama Medical Univ ,  学校法人 埼玉医科大学 ,  有限会社 代謝制御分子研究所

发明人： TOO KANJI ,  TANAI TAKEO ,  KATAGIRI TAKENOBU

IPC分类号： A61K38/22 ,  A61K35/12 ,  A61K35/16 ,  A61L27/00 ,  A61P19/08 ,  C12N5/077

CPC分类号： A61K35/28 ,  A61K35/16 ,  A61K35/19 ,  A61K38/1875 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3895 ,  C12N5/0654 ,  C12N2500/84 ,  C12N2501/155 ,  A61K2300/00

摘要： PROBLEM TO BE SOLVED: To provide a method for not only boosting the induction of differentiation from mesenchymal stem cells and mesenchymal cells other than osteoblast cells to the osteoblast cells, but also markedly promoting the differentiation and maturation of the osteoblast cells, and further a preventing and treating agent of the bone disorder accompanied by bone fracture and the reduction of bone mass, especially a medicine applicable to a stent device for transplantation and artificial bone prosthetic material necessary for the treatment of the broken bone and regeneration treatment in the bone disorder such as the reduction of bone mass, etc. SOLUTION: This method for promoting the differentiation from the mesenchymal cells to the osteoblast cells by simultaneous use of platelet rich plasma and bone formation-inducing protein; similarly the method for promoting the differentiation and maturation of the precursor cells of the osteoblast cells and/or the osteoblast cells; the agent for preventing and treating the bone disorder accompanied by the bone fracture and the reduction of the bone mass, comprising the simultaneous use of the platelet rich plasma and bone formation-inducing protein; and the osteoblast cells used for the prevention and treatment of the bone disorder accompanied by the bone fracture and reduction of the bone mass, prepared by culturing the mesenchymal cells in the presence of the platelet rich plasma and the bone formation-inducing protein are provided. COPYRIGHT: (C)2009,JPO&INPIT

摘要翻译： 待解决的问题：提供一种不仅增强从成骨细胞以外的间充质干细胞和间充质细胞向成骨细胞分化的诱导的方法，而且还显着促进成骨细胞的分化和成熟，以及 另外，伴随骨折的骨骼疾病的预防和治疗剂以及骨质量的减少，特别是适用于用于骨的治疗所需的用于移植的支架装置和人造骨修复材料的药物和骨再生治疗 紊乱如骨量减少等。解决方案：通过同时使用富血小板血浆和骨形成诱导蛋白促进从间充质细胞分化成成骨细胞的方法。 类似地，促进成骨细胞和/或成骨细胞的前体细胞的分化和成熟的方法; 用于预防和治疗伴随骨折的骨骼疾病和骨量减少的药剂，包括同时使用富血小板血浆和造骨诱导蛋白质; 并且提供了用于预防和治疗伴随血液骨架和骨形成诱导蛋白质的间充质细胞骨骨折和骨量减少的骨骼疾病的成骨细胞。 版权所有（C）2009，JPO＆INPIT