专利检索 ap:("ボーシュアンドロームインコーポレイティド") AND inv:"ドナルドハイエスジェイムズ" 第 1 页

1.

发明专利
How to solubility to prepare a suspension of small material 审中-公开

公开(公告)号：JP2012521432A

公开(公告)日：2012-09-13

申请号：JP2012502122

申请日：2010-03-18

申请人： ボーシュアンドロームインコーポレイティド

发明人： ドナルドハイエスジェイムズ , ケー．マクレオドスティーブン , ジェイ．ステインダニエル , エル．ハーバードナルド

IPC分类号： A61K9/10 , A61K45/00 , A61K47/32

CPC分类号： A61K9/10 , A61K9/0048 , A61K31/00 , A61K31/196 , A61K31/4709 , A61K31/55 , A61K31/573 , A61K31/7052

摘要： A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient (“API”) having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process.