公开(公告)号：JP2006149974A

公开(公告)日：2006-06-15

申请号：JP2004348961

申请日：2004-12-01

Applicant: Japan Lifeline Co Ltd ,  Keio Gijuku ,  学校法人慶應義塾 ,  日本ライフライン株式会社

Inventor： ARAI TSUNENORI ,  SUGA ERIKO ,  KAWABATA TAKASHI

IPC: A61M25/00 ,  A61F2/82 ,  A61M29/00

CPC classification number: A61N5/0601 ,  A61B18/245 ,  A61B18/26 ,  A61B2017/22002 ,  A61B2018/263 ,  A61N2005/0602

Abstract: PROBLEM TO BE SOLVED: To provide an apparatus having low invasive property to a patient, which is capable of reducing smooth muscle cells reproducing in a damaged portion of a blood vessel to cause restenosis or suppressing the adhesion of hematopoietic stem cells by a sound pressure wave generated when bubbles shrink and disappear, the bubbles being generated by irradiating the inside of a blood vessel with high-strength pulse light and generating steam bubbles, and also which is capable of adjusting the sound pressure of the sound pressure wave to be induced by adjusting the shape and largeness of the steam bubbles to be generated. SOLUTION: This vascular restenosis preventive therapeutic apparatus reduces the smooth muscle cells reproducing in an operated region after angioplasty by the expansion of a blood vessel by the sound pressure wave induced by irradiation with high-strength pulse light, the generation of the steam bubbles, and the collapse of the steam bubbles. The apparatus generates the steam bubbles where the length of a lateral direction relative to a high-strength pulse light irradiating direction is 50-500% in size with respect to the length of a lengthwise direction, and by which the smooth muscle cells are damaged by sound pressure when the sound pressure wave induced by the collapse of the steam bubbles hits the wall of the blood vessel. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种对患者具有低侵入性的装置，其能够减少血管损伤部分中的平滑肌细胞再现，引起再狭窄或抑制造血干细胞的粘附 当气泡收缩和消失时产生的声压波，通过用高强度脉冲光照射血管内部并产生蒸汽气泡而产生的气泡，并且还能够将声压波的声压调节为 通过调节要产生的蒸汽气泡的形状和大小而引起的。 解决方案：该血管再狭窄预防治疗装置通过由高强度脉冲光照射引起的声压波膨胀血管而使血管成形术后的手术区域的平滑肌细胞再生减少，产生蒸汽 气泡，以及蒸汽泡的崩溃。 该装置产生相对于高强度脉冲光照射方向的横向长度相对于长度方向长度为50-500％的蒸汽气泡，平滑肌细胞由此被损坏 当由蒸汽泡的塌陷引起的声压波击中血管壁时的声压。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2006102325A

公开(公告)日：2006-04-20

申请号：JP2004295374

申请日：2004-10-07

Applicant: Keio Gijuku ,  学校法人慶應義塾

Inventor： ARAI TSUNENORI ,  SUGA ERIKO ,  YAMASHITA ERIKA

IPC: A61B1/00 ,  A61M25/01 ,  G02B23/24

CPC classification number: A61B1/0051 ,  A61B1/00167 ,  A61B1/0052 ,  A61B1/0055 ,  A61B1/07 ,  A61M25/0054 ,  A61M25/0074 ,  A61M25/0158 ,  A61M2025/0064 ,  G02B23/2476

Abstract: PROBLEM TO BE SOLVED: To provide a tubule which is used by inserting it into a lumen part of a tubular body or a space part of a structure, can judge the bending direction of the tubule tip by a sensor at the tubule tip by illuminating a light, and furthermore, can bend the tubule tip in an arbitrary direction by an actuator at the tubule tip. SOLUTION: This tubule is to be used by inserting it into the lumen part of the tubular body or the space part of the structure, and includes a device sensing light illumination and/or the actuator operated by light illumination at the tubule tip. The tubule for internal observation or internal processing has a light transmission means in the tubule, irradiates light to the device and/or the actuator by the light transmission means, and monitors and/or controls the bending degree of the tubule tip by the action of the device or the actuator. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：为了提供通过将其插入管状体或结构的空间部分的管腔部分而使用的小管，可以通过小管尖端处的传感器来判断小管尖端的弯曲方向 通过照亮光，并且还可以通过小管尖端的致动器在任意方向上弯曲小管尖端。

解决方案：该小管通过将其插入管状体或结构的空间部分的内腔部分中而被使用，并且包括感测光照射的装置和/或通过在小管尖处的光照射操作的致动器 。 用于内部观察或内部处理的小管在小管中具有光传输装置，通过光传输装置将光照射到装置和/或致动器，并且通过动作来监视和/或控制小管尖端的弯曲度 该装置或致动器。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2004357792A

公开(公告)日：2004-12-24

申请号：JP2003157074

申请日：2003-06-02

Applicant: Keio Gijuku ,  学校法人慶應義塾

Inventor： ARAI TSUNENORI ,  SUGA ERIKO

IPC: A61B18/20 ,  A61B17/00

Abstract: PROBLEM TO BE SOLVED: To provide an apparatus having low invasive property to a patient, which is capable of reducing smooth muscle cells reproducing in a damaged portion of a blood vessel to cause restenosis or suppressing the adhesion of hematopoietic stem cells from adhering by a sound pressure wave generated when bubbles shrink and disappear, the bubbles being generated by irradiating the inside of a blood vessel with high-strength pulse light by a high-strength pulse light irradiating means and generating steam bubbles inside the blood vessel.
SOLUTION: A vascular restenosis preventive therapeutic apparatus reduces the smooth muscle cells which perform evaluated migration/fixation and growth in an operated region after angioplasty by the expansion of a blood vessel by an acoustic pressure wave induced by irradiation with high-strength pulse light. This apparatus includes a high-strength pulse light irradiating means capable of inducing a sound pressure wave inside the blood vessel.
COPYRIGHT: (C)2005,JPO&NCIPI