公开(公告)号：JP2014024811A

公开(公告)日：2014-02-06

申请号：JP2012167700

申请日：2012-07-27

申请人： Nippon Soda Co Ltd ,  日本曹達株式会社

发明人： NODA KAORU ,  MATSUMOTO TAKEO

IPC分类号： C07D257/04 ,  C07B61/00

摘要： PROBLEM TO BE SOLVED: To provide a method of producing a 1H-tetrazole derivative represented by general formula (I), in a solvent including water.SOLUTION: An azide compound of an alkali metal or an alkali earth metal and a compound represented by general formula (III) (Y is an alkyl group, an aryl group, an arylalkyl group, a silyl group having substituents, or a silylalkyl group having substituents, X is a halogen atom, p is 0 or 1, q is 0 or 1, Ris an alkyl group when q is 0, an alkylene group when q is 1, Ris an unsubstituted aryl group or an aryl group having substituents, note that q is 1 when p is 0.) are reacted in a mixed solvent containing water, an aromatic hydrocarbon-based solvent and a phase-transfer catalyst.

摘要翻译： 待解决的问题：提供一种在包含水的溶剂中制备由通式（I）表示的1H-四唑衍生物的方法。溶液：碱金属或碱土金属的叠氮化合物和由通式 式（III）（Y为烷基，芳基，芳烷基，具有取代基的甲硅烷基或具有取代基的甲硅烷基烷基，X为卤素原子，p为0或1，q为0或1， 当q为0时为烷基，q为1时为亚烷基，R为未取代的芳基或具有取代基的芳基，p为0时q为1）在含水混合溶剂中反应， 芳烃类溶剂和相转移催化剂。