公开(公告)号：JPH07149765A

公开(公告)日：1995-06-13

申请号：JP19311694

申请日：1994-08-17

申请人： SANWA KAGAKU KENKYUSHO CO

发明人： BABA YUTAKA ,  SUZUKI TOMOO ,  SUZUKI TSUNEMASA ,  HIROOKA KIYOTAKA ,  KURONO MASATSUNE ,  SAWAI KIICHI

IPC分类号： A61K31/00 ,  A61K31/40 ,  A61K31/407 ,  A61P25/00 ,  A61P25/02 ,  A61P25/18 ,  A61P25/28 ,  C07D487/04

摘要： PURPOSE:To obtain a new compound useful as a cerebral function improver such as an anti-dementia, showing strong muscarine receptor operation activity and a wide safe range, having a specific skeleton structure. CONSTITUTION:This compound has a skeleton structure of formula I [R1 is H, a 1-4C alkyl or an acyl; R2 and R3 are each H, a 1-4C alkyl, phenyl, a halogen, cyano, acyl, nitro, a 1-2C alkoxy or a (substituted) amido; (n) is 1-3; dotted line is a ring which occasionally exists], to be concrete, 1-[N-(1-azabicyclo [3.3.0] octan-5-yl) methyl-N-methylamino]-4-chloronaphthalene. For example, a compound of formula II is converted into a diazo compound, which is halogenated and cyanated and the prepared reaction product is converted into a salt to give the objective compound.

公开(公告)号：JPH05139963A

公开(公告)日：1993-06-08

申请号：JP30222491

申请日：1991-11-19

申请人： SANWA KAGAKU KENKYUSHO CO

发明人： KURONO MASATSUNE ,  BABA YUTAKA ,  SUZUKI TOMOO ,  SUZUKI TSUNEMASA ,  HIROOKA KIYOTAKA ,  SAWAI KIICHI

IPC分类号： A61K31/135 ,  A61P25/00 ,  A61P25/28 ,  C07C211/59

摘要： PURPOSE:To obtain an antidemential agent having high safety, applicable over a long period and suitable as an agent for improving cerebral function, e.g. treating agent for senile dementia by using an aminonitronaphthalene derivative as an active component. CONSTITUTION:The objective antidemential agent contains the compound of formula (the position of NH2 is 1 or 2-site; that of NO2 is 1, 2, 3, 4, 5, 6, 7 or 8-site) such as 1-amino-2-naphthalene as an active component. The daily dose of the compound is preferably 0.01-100mg for adult.

公开(公告)号：JPH06184152A

公开(公告)日：1994-07-05

申请号：JP25354692

申请日：1992-08-31

申请人： SANWA KAGAKU KENKYUSHO CO

发明人： KURONO MASATSUNE ,  BABA YUTAKA ,  SUZUKI TOMOO ,  SUZUKI TSUNEMASA ,  HIROOKA KIYOTAKA ,  SAWAI KIICHI

IPC分类号： A61K31/135 ,  A61K31/00 ,  A61K31/165 ,  A61K31/40 ,  A61K31/47 ,  A61K31/473 ,  A61P25/28 ,  C07C211/53 ,  C07C211/57 ,  C07C211/59 ,  C07C211/61 ,  C07C237/06 ,  C07C237/10 ,  C07D215/38 ,  C07D219/12 ,  C07D487/04 ,  A61K31/645

摘要： PURPOSE:To provide a new compound having brain function-improving activity, thus useful for the prevention or curing of Alzheimertype dementia. CONSTITUTION:The objective compound of formula I [A is CH, N or N oxide; R1 is nitro or amino; R2 is H, lower alkyl or acyl; R3 is formula II ((m) is 0 or 1; (n) is 0-3; R4 and R5 are each H or lower alkyl; R6 and R7 are each H, lower alkyl, etc.; dotted line is a ring present as the case may be], e.g. 4-(1-azabicyclo[3,3,0]octan-5-yl)methylamino-3-nitroquinoline. The compound of the formula I can be obtained by reaction between a compound of formula III (X is halogen or alkoxy) and a compound of formula IV in a solvent (e.g. DMF) or in the absence of a solvent at 0-180 deg.C. The compound of the formula I is low toxic and excellent in safety, and can be administered for a long period of time.

公开(公告)号：JPS6422883A

公开(公告)日：1989-01-25

申请号：JP17717387

申请日：1987-07-17

申请人： SANWA KAGAKU KENKYUSHO CO

发明人： KURONO MASATSUNE ,  SUZUKI TSUNEMASA ,  SUZUKI TOMOO ,  HIROOKA KIYOTAKA ,  MATSUMOTO KOJI ,  OZAWA HIROSHI ,  SAWAI KIICHI

IPC分类号： C07F7/10 ,  A61K31/695 ,  A61P25/28 ,  C07F7/08

摘要： NEW MATERIAL:A compound expressed by formula I [R1 represents H or trialkylsilyl; R2 and R3 represent H; R4 represents alkyl; R5 represents formulae II or III (R6 and R7 represent alkyl; n and m are 1-3), R4 and R5 may link with each other to represent N- or Si-containing heterocyclic ring or piperadine ring having formula IV as substituent group, when R1 is H; R2 and R4 as well as R3 and R5 represent heterocyclic ring linked through alkylene chain, when R1 is trialkylsilyl]. EXAMPLE:N-[2-[(Isopropyl)(trimethylsilylmethyl)amino]ethyl]-2-oxo-1-py rrolidine acetamide. USE:A prophylactic and remedial agent for cerebral dysfunction. PREPARATION:A compound expressed by formula V (R represents H or lower alkyl) is reacted with a compound expressed by formula VI and the reaction product, as necessary, is converted into a salt.