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公开(公告)号：JP2008303187A
公开(公告)日：2008-12-18
申请号：JP2007152868
申请日：2007-06-08
申请人： Shiseido Co Ltd , 株式会社資生堂
IPC分类号： A61K31/4166 , A61K8/49 , A61P17/00 , A61Q19/00 , C07D233/32
摘要： PROBLEM TO BE SOLVED: To provide an agent for promoting the formation, maturation of cornified envelope (hereinafter referred as CE).
SOLUTION: This agent for promoting the formation and maturation of CE comprises an imidazolidinone derivative represented by formula (1) and/or its salt.
COPYRIGHT: (C)2009,JPO&INPIT摘要翻译： 待解决的问题：提供促进形成的角质化包膜（以下称为CE）的成熟剂。 解决方案：用于促进CE的形成和成熟的该试剂包含由式（1）表示的咪唑啉酮衍生物和/或其盐。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2008303185A
公开(公告)日：2008-12-18
申请号：JP2007152803
申请日：2007-06-08
申请人： Shiseido Co Ltd , 株式会社資生堂
IPC分类号： A61K31/4015 , A61K8/49 , A61P17/16 , A61Q19/00 , C07D207/27
摘要： PROBLEM TO BE SOLVED: To provide an agent for promoting the formation and maturation of cornified envelope (hereinafter referred as CE).
SOLUTION: This agent for promoting the formation and maturation of CE comprises a pyrrolidone derivative represented by the general formula (1) (wherein, R is H, a 1-4C straight chain or branched alkyl having zero to three hydroxy groups, or a 3-7C cycloalkyl groups having zero to five hydroxy groups) and/or its salt.
COPYRIGHT: (C)2009,JPO&INPIT摘要翻译： 待解决的问题：提供促进角质化包膜的形成和成熟的试剂（以下称为CE）。 促进CE的形成和成熟的试剂包含通式（1）表示的吡咯烷酮衍生物（其中，R为H，具有0〜3个羟基的1-4C直链或支链烷基， 或具有0至5个羟基的3-7C环烷基）和/或其盐。 版权所有（C）2009，JPO＆INPIT
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3.发明专利4-alkylresorcinol derivative and bleaching agent containing the same as active ingredient 审中-公开含有它的4-ALKYLRESORCINOL衍生物和漂白剂作为活性成分
公开(公告)号：JP2006124357A
公开(公告)日：2006-05-18
申请号：JP2004318481
申请日：2004-11-01
申请人： Shiseido Co Ltd , 株式会社資生堂
摘要： PROBLEM TO BE SOLVED: To provide a 4-alkylresorcinol derivative having an excellent bleaching effect and excellent safety.
SOLUTION: This 4-alkylresorcinol derivative represented by the general formula (I) (R
1 is a branched alkyl selected from 1-ethylpropyl, 1-ethyl-2-methylpropyl, 1-isopropyl-2-methylpropyl, 1-butylpentyl and 1-isobutyl-3-methylbutyl) or its salt. The 4-alkylresorcinol derivative (I) has a good melamine production-inhibiting effect and low cytotoxicity. The 4-(1-branched alkyl) resorcinol derivative is obtained by reacting a 4-acylresorcinol with an organic metal compound to introduce an alkyl group into the carbonyl carbon, and then reducing the product.
COPYRIGHT: (C)2006,JPO&NCIPI摘要翻译： 待解决的问题：提供具有优异的漂白效果和优异的安全性的4-烷基间苯二酚衍生物。 解决方案：由通式（I）表示的4-烷基间苯二酚衍生物（R 1 SP＆lt; SP＆gt;是选自1-乙基丙基，1-乙基-2-甲基丙基，1-异丙基 - 2-甲基丙基，1-丁基戊基和1-异丁基-3-甲基丁基）或其盐。 4-烷基间苯二酚衍生物（I）具有良好的三聚氰胺抑制作用和低细胞毒性。 4-（1-支链烷基）间苯二酚衍生物是通过使4-酰基间苯二酚与有机金属化合物反应，将烷基引入羰基碳中，然后还原产物。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2010248118A
公开(公告)日：2010-11-04
申请号：JP2009098697
申请日：2009-04-15
申请人： Shiseido Co Ltd , 株式会社資生堂
摘要： PROBLEM TO BE SOLVED: To provide a composition showing excellent antiseptic and antifungal properties even when a bivalent glycol and an alcohol are blended in a low amount or not blended in a skin care preparation containing an ultraviolet absorber.
SOLUTION: The skin care preparation includes an ultraviolet absorber, 3 mass% or less of a lower alcohol, 10 mass% or less of a bivalent glycol, and 0.3 to 5 mass% of a glycerin monoalkyl ether having a 4-5C alkyl group. The skin care preparation preferably does not contain an alcohol and/or a bivalent glycol.
COPYRIGHT: (C)2011,JPO&INPIT摘要翻译： 待解决的问题：即使当二价乙二醇和醇以低量混合或不掺入含有紫外线吸收剂的护肤制剂中时，也提供显示出优异的防腐和抗真菌性的组合物。 皮肤护理制剂包括紫外线吸收剂，3质量％以下的低级醇，10质量％以下的二价乙二醇，0.3〜5质量％的具有4-5℃的甘油单烷基醚 烷基。 皮肤护理制剂优选不含醇和/或二价二醇。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2008303186A
公开(公告)日：2008-12-18
申请号：JP2007152826
申请日：2007-06-08
申请人： Shiseido Co Ltd , 株式会社資生堂
IPC分类号： A61K8/49 , A61K31/4166 , A61P17/00 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a formation/maturation promotor of cornified envelope (hereinafter abbreviated to as CE).
SOLUTION: The present invention provides a CE formation and/or maturation promotor for promoting formation and/or maturation of CE, composed of an imidazolidinone derivative represented by general formula (1) (wherein R
1 and R
2 are each independently a hydrogen atom, a 1-4C straight-chain or branched alkyl group having 0-3 hydroxy groups or a 3-7C cycloalkyl group having 0-5 hydroxy groups) and/or its salt.
COPYRIGHT: (C)2009,JPO&INPIT摘要翻译： 要解决的问题：提供角质化包膜的形成/成熟促进剂（以下简称为CE）。 解决方案：本发明提供一种促进CE形成和/或成熟的CE形成和/或成熟启动子，其由通式（1）表示的咪唑啉酮衍生物（其中R SB = 1 / 和R SB 2各自独立地为氢原子，具有0-3个羟基的1-4C直链或支链烷基或具有0-5个羟基的3-7C环烷基）和/ 或其盐。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2006096744A
公开(公告)日：2006-04-13
申请号：JP2005202590
申请日：2005-07-12
申请人： Shiseido Co Ltd , 株式会社資生堂
摘要： PROBLEM TO BE SOLVED: To provide a skin care composition for external use, which improves troubles such as skin parakeratosis and/or horny layer barrier function deterioration.
SOLUTION: This skin care composition which is used for external use and promotes the formation and/or maturity of cornified envelope to improve troubles such as skin parakeratosis and/or horny layer barrier function deterioration contains an amidinosulfonic acid of formula (1) [A is sulfur atom or oxygen atom; (n) is an integer of 1 to 5] and/or its salt.
COPYRIGHT: (C)2006,JPO&NCIPI摘要翻译： 要解决的问题：提供一种用于外部使用的护肤组合物，其改善诸如皮肤角化不全和/或角质层屏障功能恶化的麻烦。 解决方案：用于外部使用并促进角质层包膜的形成和/或成熟以改善诸如皮肤角化不全和/或角质层屏障功能恶化的麻烦的该护肤组合物含有式（1）的脒基磺酸， [A是硫原子或氧原子; （n）为1〜5的整数]和/或其盐。 版权所有（C）2006，JPO＆NCIPI
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7.发明专利1,2-disubstituted piperidine derivative and hair growth stimulant, skin preparation for external use 有权1,2-取代哌啶衍生物和头发生长刺激素，用于外用的皮肤制剂
公开(公告)号：JPH11279149A
公开(公告)日：1999-10-12
申请号：JP1926999
申请日：1999-01-28
申请人： Shiseido Co Ltd , 株式会社資生堂
IPC分类号： C07D211/22 , A61K8/00 , A61K8/49 , A61K31/00 , A61K31/445 , A61K31/4458 , A61K31/4468 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P17/00 , A61P17/14 , A61P43/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , C07D211/26 , C07D211/32 , C07D211/38 , C07D211/46 , C07D211/58 , C07D211/60 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain the subject new compound having an excellent trichogenous effect, an excellent hair-restoring effect and an excellent hair falling-preventing effect and useful as a hair growth stimulant or a skin preparation for external use. SOLUTION: A compound of formula I [one of A and B is R (1-30C hydrocarbon group); the other is (CH2 )n -NR R ; Y is CO or the like; Z is O or the like; R and R are each H, a lower alkyl or the like, or R and R together form a three to seven-membered heterocyclic group; or NR -(CH2 )n -NR R and NR -(CH2 )n -NR R are each a group of formula II (the ring E is a six-membered or seven-membered heterocyclic group); R is H, a halogen or the like; R and R are each H, a lower alkyl or the like; (1) is 0 or 1; (m) is 2-5; (n) is 0-5]. For example, a compound of formula III. The compound of formula I is obtained by reacting a compound of formula IV with an amine of formula V and subsequently reacting the obtained compound with an amine of formula IV.
摘要翻译： 要解决的问题：获得具有优异的毛发效应，优异的头发恢复效果和优异的脱毛防止效果并且可用作头发生长兴奋剂或外用皮肤制剂的本发明新化合物。 解决方案：式I化合物[A和B之一为R 1（1-30C烃基））。 另一个是（CH 2）n -NR 2 R 3; Y是CO等; Z是O等; R 2和R 3各自为H，低级烷基等，或者R 2和R 3一起形成3至7元杂环基; 或NR 5 - （CH 2）n -NR 2 R 3和NR 6 - （CH 2）n -NR 2 R 3各自为式II的基团（环E为 六元或七元杂环基）; R 4是H，卤素等; R 5和R 6各自为H，低级烷基等; （1）为0或1; （m）为2-5; （n）为0-5]。 例如，式III化合物。 式I的化合物是通过使式Ⅳ化合物与式Ⅴ的胺反应而得到的，随后使得到的化合物与式Ⅳ的胺反应。
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公开(公告)号：JP2014111640A
公开(公告)日：2014-06-19
申请号：JP2014023264
申请日：2014-02-10
申请人： Shiseido Co Ltd , 株式会社 資生堂
CPC分类号： A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q19/02 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new agent effective in prevention and suppression of skin aging and a whitening agent effective in prevention and suppression of pigmentation such as spots, freckles, and dullness from a viewpoint of the relation between a heparanase and skin aging.SOLUTION: Disclosed is a heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by following general formula (I) or a salt thereof, wherein n is an integer of 1 to 3, Ris a hydrogen atom or a C1-6 hydrocarbon group optionally substituted with a hydroxy group, X is -CH- or a group represented by -N(R)-, and Ris a hydrogen atom or a C1-6 hydrocarbon group optionally substituted with a hydroxy group.
摘要翻译： 要解决的问题：从乙酰肝素酶和皮肤老化之间的关系的观点出发，提供有效预防和抑制皮肤老化的新试剂和有效预防和抑制斑点，雀斑和暗淡等色素沉着的增白剂。 解决方案：公开了一种乙酰肝素酶活性抑制剂，其包含作为活性成分的由以下通式（I）表示的环状羧酰胺衍生物或其盐，其中n为1〜3的整数，R为氢原子或C1- 6任选被羟基取代的烃基，X是-CH-或由-N（R） - 表示的基团，R 1是氢原子或任选被羟基取代的C 1-6烃基。
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9.发明专利4-alkylresorcinol derivative and external preparation for skin containing the same 有权4-ALKYLRESORCINOL用于含有其的皮肤的衍生物和外用制剂
公开(公告)号：JP2012020980A
公开(公告)日：2012-02-02
申请号：JP2010161274
申请日：2010-07-16
申请人： Shiseido Co Ltd , 株式会社 資生堂
CPC分类号： C07F9/09 , A61K8/55 , A61K2800/782 , A61Q19/02 , C07F9/12
摘要： PROBLEM TO BE SOLVED: To provide a compound having a high skin whitening effect and excellent safety and stability, and an external preparation for skin with which this compound is blended.SOLUTION: The compound is a 4-alkylresorcinol derivative represented by general formula (1) or a salt thereof (in formula, Ris a branched or cyclic 3-7C alkyl group or a straight chain 2-5C alkyl group, Rand Rare each independently a hydrogen atom or a group represented by -P(O)(OR)(OR) and at least one of Rand Ris a group represented by -P(O)(OR)(OR), and Rand Rare each independently a hydrogen atom or a straight chain or branched 2-5C alkyl group).
摘要翻译： 要解决的问题：提供具有高皮肤美白效果和优异的安全性和稳定性的化合物，以及与该化合物混合的皮肤外用制剂。 解决方案：该化合物是由通式（1）表示的4-烷基间苯二酚衍生物或其盐（式中，R
1是支链或环状的3-7C 烷基或直链2-5C烷基，R 2 和R 3 各自独立地为氢原子或基团 由P（O）（OR 4 ）表示（OR 5 ），R 2 和R 3 是由-P（O）（OR 4 ）表示的组 或 5 ），并且R 4 和R 5 氢原子或直链或支链的2-5C烷基）。 版权所有（C）2012，JPO＆INPIT -
公开(公告)号：JP2010024193A
公开(公告)日：2010-02-04
申请号：JP2008188569
申请日：2008-07-22
申请人： Shiseido Co Ltd , 株式会社資生堂
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially advantageously producing a 4-alkylresorcinol and a 4-alkenylresorcinol at relatively low temperatures without a corrosive substance and a harmful substance. SOLUTION: The method for producing the 4-alkenylresorcinol of general formula (1) (wherein R 2 is a 1-12C alkoxyl group, phenyl group, or a 3-12C linear, branched or cyclic alkenyl group) is characterized by reacting resorcinol with an alkenyl halide: R 2 -X (wherein X is a halogen) in the presence of a base. Also, the method for producing the 4-alkylresorcinol of general formula (2) (wherein R 1 is a 1-12C alkoxyl group, phenyl group, or a 3-12C linear, branched or cyclic alkyl group) is characterized by reducing the alkenyl group of the compound of general formula (1) wherein R 2 is the same as above. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译： 待解决的问题：提供一种在没有腐蚀性物质和有害物质的情况下在较低温度下工业上有利地生产4-烷基间苯二酚和4-链烯基间苯二酚的方法。 解决方案：制备通式（1）的4-链烯基间苯二酚的方法（其中R 2 SP 2是1-12C烷氧基，苯基或3-12C直链，支链或 环状链烯基）的特征在于：在碱的存在下，使间苯二酚与烯基卤反应：R 2 SP 2 -X（其中X为卤素）。 另外，通式（2）的4-烷基间苯二酚的制造方法（其中，R 1 SP 1是1-12C烷氧基，苯基或3-12C直链，支链或环状的烷基 ）的特征在于还原通式（1）的化合物的烯基，其中R 2 SP 2与上述相同。 版权所有（C）2010，JPO＆INPIT
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