公开(公告)号：JP2014129365A

公开(公告)日：2014-07-10

申请号：JP2014020406

申请日：2014-02-05

Applicant: Zogenix Inc ,  ゾゲニクス インコーポレーティッド

Inventor： FARR STEPHEN J ,  JOHN TURANIN ,  ROGER HAWLEY ,  JEFFREY A SCHUSTER

IPC: A61K45/06 ,  A61K9/10 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/439 ,  A61K31/454 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61P1/08 ,  A61P25/04 ,  A61P25/06 ,  A61P43/00

CPC classification number: A61M5/30 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/0024 ,  A61K9/16 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/44 ,  A61K31/454 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36

Abstract: PROBLEM TO BE SOLVED: To provide a system applicable to needle-free delivery which comprises a sustained release formulation for the treatment of migraine which is debilitating neurological disease, related head pain such as cluster headache and the symptoms.SOLUTION: A system comprises: a drug delivery device; and a biphasic formulation which is comprised of a first component which provides a fast acting pain alleviation effect within one hour or less, and a second component which has high viscosity and provides a long term alleviation effect over a period of 4 hours or more. The drug delivery device is a needle-free injector, and the second component is composed of a carrier which provides controlled release of a drug over a period of 4 hours or more. The system comprises: a drug as the first component selected from the group consisting of sumatriptan, almotriptan, rizatriptan, eletriptan and zomitriptan; and a drug as the second component selected from the group consisting of naratriptan and frovatriptan.

Abstract translation: 要解决的问题：提供适用于无针输送的系统，其包括用于治疗偏头痛的缓释制剂，所述缓释制剂是令人衰弱的神经疾病，相关头痛如丛集性头痛和症状。解决方案：系统包括： 给药装置; 以及由在1小时以内提供快速作用的疼痛缓解作用的第1成分和4小时以上具有高粘度且长期缓解作用的第2成分组成的双相配方。 药物递送装置是无针注射器，第二部件由在4小时以上的时间内提供药物的受控释放的载体组成。 该系统包括：药物作为选自舒马曲坦，阿莫曲坦，利扎曲坦，依他曲坦和佐米曲坦的第一组分; 作为选自由纳他曲坦和呋喃曲坦组成的组的第二组分的药物。