公开(公告)号：JPH04266828A

公开(公告)日：1992-09-22

申请号：JP32068991

申请日：1991-12-04

申请人： GREEN CROSS CORP

发明人： KAN EIFUKU ,  KEI KOKI ,  BUN SADASUKE ,  KIN HARUMOTO ,  KAN JINKEN ,  KIN SHOBAI

IPC分类号： A61K36/00 ,  A61K20060101 ,  A61K36/47 ,  A61K36/888 ,  A61P1/16 ,  A61P35/00 ,  A61P37/04 ,  B01D11/00 ,  B01D11/02 ,  C07G5/00 ,  C07G99/00 ,  A61K35/78

摘要： PURPOSE: To provide a new plant extract that is extracted from barks of a plant in Phellodendron family and from defatted seeds of a plant in Croton family and shows excellent anticancer and immuno-potentiating effects practically without toxicity. CONSTITUTION: Barks of a plant in Phellodendron family (particularly Phellodendron anurense Rupr. is suitable) and defatted seeds of a plant is Croton family (particularly Croton tiglium (L) is suitable) are mixed, preferably at a weight ratio of 1/2-2/1 and treated with an organic solvent to remove the soluble components. Then, the new extract having properties shown in the table is extracted from the resultant mixture with water. This extract is useful as a medicine for treating diseases caused by defects in homeostatis of immune system and neurosecretory system.

公开(公告)号：JPS5025040B1

公开(公告)日：1975-08-20

申请号：JP1474666

申请日：1966-03-11

IPC分类号： B01D11/02 ,  A24B15/24 ,  A24B15/26 ,  C07G5/00 ,  A24B15/02 ,  B01D11/04

公开(公告)号：JPS4880789A

公开(公告)日：1973-10-29

申请号：JP1085172

申请日：1972-01-28

IPC分类号： C12P21/00 ,  A01H4/00 ,  A61K36/24 ,  C07G5/00

公开(公告)号：JP2021513346A

公开(公告)日：2021-05-27

申请号：JP2020542865

申请日：2019-02-08

申请人： アンテイア インコーポレイテッド

发明人： スモルケ クリスティーナ ディー. ,  トレンチャード イシス ,  ホーキンス クリスティ エム. ,  ソーディー キャサリン

IPC分类号： C12N1/21 ,  C07G5/00 ,  C12N1/19

摘要： プロモルフィナンアルカロイドのモルフィナンアルカロイドへの変換の増大によってプロモルフィナン、モルフィン、ナル-オピオイド、およびノル-オピオイドアルカロイド生成物を生成する方法を提供する。本方法は、プロモルフィナンアルカロイドを少なくとも1種の酵素と接触させる工程を含む。プロモルフィナンアルカロイドを少なくとも1種の酵素と接触させる工程により、プロモルフィナンアルカロイドがモルフィナンアルカロイドに変換される。

公开(公告)号：JPH06321971A

公开(公告)日：1994-11-22

申请号：JP16305893

申请日：1993-05-27

申请人： INDENA SPA

发明人： IJIO BONBAADERII

IPC分类号： A61K8/55 ,  A61K8/00 ,  A61K8/49 ,  A61K8/58 ,  A61K8/97 ,  A61K9/00 ,  A61K31/435 ,  A61K31/66 ,  A61K31/685 ,  A61P9/00 ,  A61P9/10 ,  A61Q19/00 ,  C07D457/02 ,  C07D457/04 ,  C07D457/06 ,  C07D459/00 ,  C07D461/00 ,  C07D491/22 ,  C07D519/04 ,  C07F9/10 ,  C07G5/00 ,  A61K7/00 ,  A61K7/48

公开(公告)号：JPH0647553B2

公开(公告)日：1994-06-22

申请号：JP32068991

申请日：1991-12-04

IPC分类号： A61K36/00 ,  A61K20060101 ,  A61K36/47 ,  A61K36/888 ,  A61P1/16 ,  A61P35/00 ,  A61P37/04 ,  B01D11/00 ,  B01D11/02 ,  C07G5/00 ,  C07G99/00 ,  A61K35/78

公开(公告)号：JPS5648509B2

公开(公告)日：1981-11-16

申请号：JP8185772

申请日：1972-08-17

IPC分类号： A61K36/18 ,  C07D209/90 ,  C07D457/02 ,  C07G5/00

公开(公告)号：JPH085796B2

公开(公告)日：1996-01-24

申请号：JP18262692

申请日：1992-07-09

申请人： STEIGERWALD ARZNEIMITTELWERK

IPC分类号： A61K36/18 ,  A61K20060101 ,  A61K9/14 ,  A61K36/00 ,  A61K36/505 ,  A61K36/66 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07G5/00 ,  A61K35/78

摘要： The invention concerns a pharmaceutical and its use for the treatment of states of agitation and nervous dysfunctions, which comprises as active ingredients extracts of Corydalis and Eschscholtzia obtained by alcohol extraction (2.5:10), optionally together with conventional additives, the weight ratio of the extract Eschscholtzia to Corydalis being in the range from 20:1 to 1:1.

公开(公告)号：JPH0753392A

公开(公告)日：1995-02-28

申请号：JP18262692

申请日：1992-07-09

申请人： STEIGERWALD ARZNEIMITTELWERK

发明人： SCHNEIDER WERNER DR ,  ELSTNER ERICH F PROF DR ,  KLEBER ELISABETH DR

IPC分类号： A61K36/18 ,  A61K20060101 ,  A61K9/14 ,  A61K36/00 ,  A61K36/505 ,  A61K36/66 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07G5/00 ,  A61K35/78

摘要： PURPOSE: To obtain the subject preparation containing, as active ingredient, each specific Corydalis decumbens extract and Eschscholzia californica extract in specified proportions, excellent in efficacy sustainability, and useful for treating e.g. depression, Parkinson's disease. CONSTITUTION: This therapeutic preparation contains, as active ingredient, Corydalis decumbens extract and Eschscholzia californica extract in the weight ratio of (20:1) to (1:1) together with, as circumstances require, conventional additive(s). These extracts, which are afforded by alcohol extraction (2.5:10) as an aqueous and/or alcohol solution, is pref. in the form of powder. It is preferable that the daily dose of the active ingredient is 2-5 mg/kg body weight.

公开(公告)号：JPH03240736A

公开(公告)日：1991-10-28

申请号：JP3701890

申请日：1990-02-16

申请人： ICHIMARU PHARCOS INC

发明人： ANDO YOSHITAKA ,  NISHIBE YUKINAGA ,  KAWAI NORIHISA ,  ANDO YUTAKA

IPC分类号： A61K36/48 ,  A61P43/00 ,  C07G5/00 ,  C07G99/00

摘要： PURPOSE:To A cell activating substance composed of a water-soluble ingredient, extracted from Sophora angustifolia Sieb. et Zucc. of a leguminous plant and having a specific molecular weight. CONSTITUTION:Water in an amount of 5-10 times based on Sophora anguetifolia Sieb. et Zucc. is added thereto and the Sophora angustifolia Sieb. et Zucc. is dipped therein at 4 deg.C for several days while being occasionally stirred. A filtrate is then collected by filtration and concentrated until the volume attains (1/10) to (1/20) under reduced pressure. An organic solvent is added to the resultant concentrate so as to provide about 60% concentration thereof. Centrifugation is carried out to collect precipitates, which are then dissolved in water to perform gel filtration using a column (25X60cm) filled with, e.g. Sephadex G-25(R) and afford a fraction eluting at a specified Kav value, e.g. 0.65-0.86. The resultant fraction is subsequently freeze-dried to provide a cell activating substance having 700-1100 molecular weight. The obtained substance can be used as a promoter for tissue culture or regeneration and treatment of ulcerated and traumatic parts.