公开(公告)号：US07741272B2

公开(公告)日：2010-06-22

申请号：US11182218

申请日：2005-07-15

申请人： Hai U. Wang ,  Zhoufeng Chen ,  David J. Anderson

发明人： Hai U. Wang ,  Zhoufeng Chen ,  David J. Anderson

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K14/705 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K38/00 ,  A61K38/19 ,  A61K49/0002 ,  C07K16/2866 ,  C12N5/0691 ,  C12N15/8509 ,  C12N2503/02 ,  G01N2333/52

摘要： Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EphrinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis.