公开(公告)号：US20140030747A1

公开(公告)日：2014-01-30

申请号：US13460116

申请日：2012-04-30

申请人： Yu Chen ,  Xihua Wang ,  Agniezska Kalinowski ,  Mi Hong ,  Pritiraj Mohanty ,  Shyamsunder Erramilli

发明人： Yu Chen ,  Xihua Wang ,  Agniezska Kalinowski ,  Mi Hong ,  Pritiraj Mohanty ,  Shyamsunder Erramilli

IPC分类号： G01N27/12

CPC分类号： G01N27/12 ,  B82Y15/00 ,  G01N27/4146

摘要： A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels having an outer surface functionalized for interaction with the species to create a surface potential, and each having a sufficiently small cross section to exhibit a shift of differential conductance into a negative bias operating region by a shift amount dependent on the surface potential. The bias and measurement circuit applies a bias voltage across two ends of the nanochannels sufficiently negative to achieve a desired dependence of the differential conductance on the surface potential. The dependence has a steeply sloped region of high amplification substantially greater than a reference amplification at a zero-bias condition, thus achieving relatively high signal-to-noise ratio. The bias and measurement circuit converts the measured differential conductance into a signal indicative of presence or activity of the species.

摘要翻译： 用于检测化学或生物物种的传感器系统包括感测元件和偏置和测量电路。 感测元件包括具有功能化以与物质相互作用以产生表面电位的外表面的纳米通道，并且每个具有足够小的横截面以显示差分电导到负偏压操作区域中的移动量取决于表面的位移量 潜在。 偏置和测量电路在纳米通道的两端施加足够负的偏置电压，以实现差分电导对表面电位的期望依赖性。 该依赖性具有高放大的急剧倾斜区域，其显着大于零偏置条件下的参考放大，从而获得相对较高的信噪比。 偏置和测量电路将测量的差分电导转换成指示物种存在或活动的信号。

公开(公告)号：US20100039126A1

公开(公告)日：2010-02-18

申请号：US12464665

申请日：2009-05-12

申请人： Yu Chen ,  Xihua Wang ,  Agniezska Kalinowski ,  Mi Hong ,  Pritiraj Mohanty ,  Shyamsunder Erramilli

发明人： Yu Chen ,  Xihua Wang ,  Agniezska Kalinowski ,  Mi Hong ,  Pritiraj Mohanty ,  Shyamsunder Erramilli

IPC分类号： G01N27/04 ,  G01R27/08

CPC分类号： G01N27/12 ,  B82Y15/00 ,  G01N27/4146

摘要： A sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface functionalized to chemically interact with the species to create a corresponding surface potential, and each having a sufficiently small cross section to exhibit a shift of a differential conductance characteristic into a negative bias operating region by a shift amount dependent on the surface potential. The bias and measurement circuit applies a bias voltage across two ends of the nanochannels sufficiently negative to achieve a desired dependence of the differential conductance on the surface potential, wherein the dependence has a steeply sloped region of high amplification substantially greater than a reference amplification at a zero-bias condition, thus achieving relatively high signal-to-noise ratio. The bias and measurement circuit converts the measured differential conductance into a signal indicative of presence or activity of the species of interest.

摘要翻译： 用于检测化学或生物物种的传感器系统包括感测元件和偏置和测量电路。 感测元件包括纳米通道，每个纳米通道的外表面被官能化以与物质发生化学相互作用以产生相应的表面电位，并且每个具有足够小的横截面以使微分电导特性转变成负偏压操作区域 位移量取决于表面电位。 偏置和测量电路将纳米通道的两端的偏置电压充分地负给以实现差分电导对表面电势的期望的依赖性，其中依赖性具有高放大的急剧下降的区域，基本上大于在 零偏置条件，从而达到较高的信噪比。 偏置和测量电路将测量的差分电导转换为指示感兴趣物种的存在或活动的信号。