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公开(公告)号：US20050180952A1
公开(公告)日：2005-08-18
申请号：US10868482
申请日：2004-06-14
申请人： Ronald Pettis , Alfred Harvey , Robert Campbell , John Mikszta , John Brittingham , Glenn Vonk , Colleen Nycz
发明人： Ronald Pettis , Alfred Harvey , Robert Campbell , John Mikszta , John Brittingham , Glenn Vonk , Colleen Nycz
IPC分类号： A61K31/496 , A61K38/20 , A61K38/21 , A61K39/395 , A61K45/00 , A61M20060101 , A61M23/00
CPC分类号： A61K9/0021 , A61K9/0019
摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents, such as therapeutic agents, through lymphatic vasculature accessed by intradermal delivery. Therapeutic agents to be delivered in accordance with the present invention include, but are not limited to, antineoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenesis agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present invention have improved bioavailability, including improved systemic distribution and improved delivery to particular tissues. Therapeutic agents delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over conventional drug delivery methods including dose sparing, increased drug efficacy, reduced side effects, reduced metastatic potential and prolonged survival.
摘要翻译： 本发明涉及用于将一种或多种生物活性剂，特别是治疗剂递送到受试者皮肤的皮内隔室的方法和装置。 本发明提供通过皮内递送获得的淋巴脉管系统递送生物活性剂如治疗剂的改进方法。 根据本发明要递送的治疗剂包括但不限于抗肿瘤剂，化学治疗剂，抗体，抗生素，抗血管发生剂，抗炎剂和免疫治疗剂。 根据本发明递送的治疗剂具有改善的生物利用度，包括改进的全身分布和改善的递送到特定组织。 根据本发明方法递送的治疗剂相对于其它药物递送方法具有改善的临床效用和治疗功效，包括腹膜内，肌内和皮下递送。 本发明的方法相对于常规药物递送方法提供益处和改进，包括剂量节省，药物功效增加，副作用减少，转移潜力降低和延长生存期。
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公开(公告)号：US20050163711A1
公开(公告)日：2005-07-28
申请号：US10867908
申请日：2004-06-14
申请人： Colleen Nycz , Glenn Vonk , John Brittingham , Ronald Pettis , Alfred Harvey , Robert Campbell , John Mikszta , Diane Sutter
发明人： Colleen Nycz , Glenn Vonk , John Brittingham , Ronald Pettis , Alfred Harvey , Robert Campbell , John Mikszta , Diane Sutter
IPC分类号： A61K49/00 , A61M20060101
CPC分类号： A61K49/0034 , A61K9/0021 , A61K49/0043 , A61K49/0058 , A61M5/46 , A61M37/00
摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly a diagnostic agent to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents in that it provides among other benefits, rapid uptake into the local lymphatics, improved targeting to a particular tissue, improved bioavailability, improved tissue bioavailability, improved tissue specific kinetics, improved deposition of a pre-selected volume of the agent to be administered, and rapid biological and pharmacodynamics and biological and pharmacokinetics. This invention provides methods for rapid transport of agents through lymphatic vasculature accessed by intradermal delivery of the agent. Methods of the invention are particularly useful for delivery of diagnostic agents.
摘要翻译： 本发明涉及用于将一种或多种生物活性剂特别是诊断剂递送到受试者皮肤的真皮内隔室的方法和装置。 本发明提供了递送生物活性剂的改进方法，因为它提供了其他益处，快速摄入局部淋巴管，改善对特定组织的靶向，改善的生物利用度，改善的组织生物利用度，改善的组织特异性动力学，改进的沉积 预先选定体积的药物，以及快速的生物和药效学以及生物和药代动力学。 本发明提供了通过皮内递送试剂获得的通过淋巴脉管系统快速转运药剂的方法。 本发明的方法对于递送诊断剂特别有用。
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