公开(公告)号：US20190247318A1

公开(公告)日：2019-08-15

申请号：US16390156

申请日：2019-04-22

申请人： Bar-Ilan University

发明人： Shlomo MARGEL ,  Michal KOLITZ DOMB ,  Stella KIEL ,  Elisheva SASON

IPC分类号： A61K9/51 ,  C08G63/91 ,  A61K38/00 ,  A61K49/00 ,  C08G63/685

CPC分类号： A61K9/5169 ,  A61K38/00 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/0058 ,  A61K49/0093 ,  C08G63/685 ,  C08G63/6852 ,  C08G63/912

摘要： Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed.

公开(公告)号：US20190241652A9

公开(公告)日：2019-08-08

申请号：US15002131

申请日：2016-01-20

申请人： CytomX Therapeutics, Inc.

发明人： Stephen James Moore ,  Margaret Thy Luu Nguyen ,  Daniel Robert Hostetter ,  Olga Vasiljeva ,  Jason Gary Sagert ,  Jonathan Alexander Terrett ,  James William West

IPC分类号： C07K16/28 ,  C07K14/00 ,  C07K7/08 ,  A61K38/05 ,  C07K16/40 ,  A61K47/48 ,  A61K49/00

CPC分类号： C07K16/28 ,  A61K38/05 ,  A61K47/6849 ,  A61K47/6851 ,  A61K49/0058 ,  A61K2039/505 ,  A61K2039/507 ,  C07K7/08 ,  C07K14/00 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/92 ,  C07K2319/50 ,  C07K2319/74

摘要： The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.

公开(公告)号：US20190240355A9

公开(公告)日：2019-08-08

申请号：US15511597

申请日：2015-09-15

申请人： The Regents of the University of Colorado, a body corporate ,  The Johns Hopkins University

发明人： Martin G. Pomper ,  Catherine A. Foss ,  Joshua M. Thurman ,  V. Michael Holers

IPC分类号： A61K49/00 ,  C07K16/18 ,  A61K51/10

CPC分类号： A61K49/0058 ,  A61K49/0043 ,  A61K51/1009 ,  A61K51/1018 ,  C07K16/18 ,  C07K2317/92 ,  G01N33/534 ,  G01N33/5695 ,  G01N2469/10

摘要： The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for detecting infectious and inflammatory cells in vivo. The presently disclosed subject matter also provides methods for detecting and/or monitoring a Mycobacterium tuberculosis (M. tuberculosis) infection in a subject, as well as methods of treating a M. tuberculosis infection in a subject.

公开(公告)号：US20190218295A1

公开(公告)日：2019-07-18

申请号：US16352194

申请日：2019-03-13

申请人： Shanghai Henlius Biotech Inc.

发明人： Weidong Jiang ,  Pei-Hua Lin ,  Chi-Ling Tseng

IPC分类号： C07K16/28 ,  A61K49/00 ,  A61K51/10 ,  A61K47/68 ,  A61P35/00 ,  C07K16/22 ,  G01N33/574

CPC分类号： C07K16/2818 ,  A61K47/6849 ,  A61K49/0058 ,  A61K51/1027 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492

摘要： Provided are anti-PD-1 antibodies, and antigen binding fragments thereof. Also provided are isolated nucleic acid molecules that encode the anti-PD-1 antibodies or antigen binding fragments thereof, related expression vectors, and host cells. Provided are methods of making anti-PD-1 antibodies, and antigen binding fragments thereof. Also provided are related pharmaceutical compositions and methods of their use to treat subjects. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20190192685A1

公开(公告)日：2019-06-27

申请号：US16098906

申请日：2017-05-04

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  UNIVERSITY OF SOUTH FLORIDA

发明人： Mark L. McLaughlin ,  David L. Morse

IPC分类号： A61K47/68 ,  A61P35/00 ,  A61P35/04

CPC分类号： A61K47/6857 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0058 ,  A61P35/00 ,  A61P35/04

摘要： The subject matter disclosed herein relates generally to cancer therapy and to anticancer compounds and imaging agents. More specifically, the subject matter disclosed herein relates to agents that target DOR and their use in the treatment of cancer.

公开(公告)号：US20190077853A1

公开(公告)日：2019-03-14

申请号：US16141914

申请日：2018-09-25

申请人： F. HOFFMANN-LA ROCHE AG ,  INSTITUT PASTEUR ,  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Pierre Lafaye ,  Sylvie Bay ,  Benoit Delatour ,  Marc Dhenain ,  Charles Duyckaerts ,  Tengfei Li ,  Matthias Vandesquille ,  Christian Czech ,  Fiona Grueninger

IPC分类号： C07K16/18 ,  G01N33/68 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K49/0041 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/10 ,  C07K2317/22 ,  C07K2317/34 ,  C07K2317/569 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2440/14 ,  G01N2800/2821

摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.

公开(公告)号：US20180193485A1

公开(公告)日：2018-07-12

申请号：US15915166

申请日：2018-03-08

申请人： City University of Hong Kong

发明人： Mengsu YANG ,  Dandan LIU

IPC分类号： A61K47/69 ,  A61P35/00 ,  A61K47/68 ,  A61K49/00 ,  C07K16/28 ,  A61K41/00 ,  A61K9/00 ,  C07K16/30 ,  A61K39/395 ,  A61N2/00

CPC分类号： A61K47/6925 ,  A61K9/0019 ,  A61K39/3955 ,  A61K39/39558 ,  A61K41/0052 ,  A61K47/6849 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0019 ,  A61K49/0045 ,  A61K49/0058 ,  A61K49/0093 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61N2/002 ,  A61P35/00 ,  C07K16/2887 ,  C07K16/30

摘要： There is disclosed a composition in the form of a nanoparticle. The nanoparticle composition has a diameter from 5 to 500 nanometers. The nanoparticle composition has i) a central core portion including magnetic Fe3O4 nanoparticles adapted to act as a heat source when subjected to a magnetic field and a chemotherapeutic agent configured to treat cancer tissues, ii)—a shell portion including a shell member encapsulating said core portion, and iii)—antibodies configured to target cancer stem cells and adhered to surface of said shell member. The chemotherapeutic agent is a heat shock protein inhibitor and is releasable on activation of the heat source due to the magnetic field, and the shell member is made of silica or a silica based material. Surface of the nanoparticle is modified with the antibodies capable of binding with a cluster of differentiation molecules on the cell surface of the target cancer stem cells, whereby by way of combination of specificity of the nanoparticle composition due to the antibody, thermo-therapeutic effect of the Fe3O4 nanoparticles, and release of the heat shock protein inhibitor on site at the target cancer stem cells, inhibition of the target cancer stem cells is synergistically and additionally enhanced is increased.

公开(公告)号：US20180177902A1

公开(公告)日：2018-06-28

申请号：US15659568

申请日：2017-07-25

申请人： GAL MARKEL

发明人： GAL MARKEL

IPC分类号： A61K51/10 ,  A61K35/17 ,  A61K38/17 ,  A61K49/00 ,  A61K51/04 ,  A61K51/08 ,  C07K14/705 ,  C07K16/30 ,  C12N5/0781 ,  C12N5/0783 ,  G01N33/569 ,  G01N33/574

CPC分类号： A61K51/10 ,  A61K35/17 ,  A61K38/1774 ,  A61K49/0004 ,  A61K49/0052 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/04 ,  A61K51/088 ,  A61K2035/122 ,  C07K14/70503 ,  C07K16/3007 ,  C07K2317/54 ,  C07K2317/732 ,  C12N5/0635 ,  C12N5/0636 ,  G01N33/56972 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/70596

摘要： The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the suppression of immune responses in a targeted fashion, by increasing the functional concentration of the CEACAM1 protein in a target tissue to create a localized protective immunity for the treatment of autoimmune diseases and diseases requiring the transplantation of tissue.

公开(公告)号：US20180177897A1

公开(公告)日：2018-06-28

申请号：US15738327

申请日：2016-06-23

申请人： The Board of Trustees of the Leland Stanford Junior University ,  THE CURATORS OF THE UNIVERSITY OF MISSOURI

发明人： KENNETH HETTIE ,  JESSICA KLOCKOW ,  TIMOTHY GLASS ,  FREDERICK T. CHIN

IPC分类号： A61K49/00 ,  G01N33/58

CPC分类号： A61K49/0043 ,  A61K49/0058 ,  C07D491/052 ,  G01N33/582 ,  G01N2458/00

摘要： The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.

公开(公告)号：US09993567B2

公开(公告)日：2018-06-12

申请号：US14795429

申请日：2015-07-09

申请人： Quark Pharmaceuticals, Inc.

发明人： Elena Feinstein

IPC分类号： A61K39/395 ,  A61K39/44 ,  C07K16/30 ,  C07K16/28 ,  A61K47/48 ,  A61K49/00 ,  A61K47/68

CPC分类号： A61K47/6849 ,  A61K39/39541 ,  A61K39/39558 ,  A61K49/0058 ,  C07K16/2851 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules, to compositions comprising the antibodies and conjugates and to methods of using the same for delivery of therapeutic agents to cells that express the ENDO180 polypeptide on the surface of the cell for treating cell proliferative diseases or disorders and fibrosis, and for controlling (modulating) tumor progression.