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    Quinazoline compounds as kinase inhibitors
    2.
    发明授权
    Quinazoline compounds as kinase inhibitors 有权
    喹唑啉化合物作为激酶抑制剂

    公开(公告)号：US08785459B2

    公开(公告)日：2014-07-22

    申请号：US13337863

    申请日：2011-12-27

    申请人： Jiann-Jyh Huang ,  Chu-Bin Liao ,  Pao-Nien Chen

    发明人： Jiann-Jyh Huang ,  Chu-Bin Liao ,  Pao-Nien Chen

    IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D239/02 ,  C07D401/00 ,  C07D403/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00

    CPC分类号： C12N9/99 ,  C07D239/94 ,  C12Y207/00

    摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.

    摘要翻译： 一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O）NHR b， 的R a和R b独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所键合的氮原子一起 ，形成杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。

    QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS
    3.
    发明申请
    QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS 有权
    喹唑啉化合物作为激酶抑制剂

    公开(公告)号：US20130165458A1

    公开(公告)日：2013-06-27

    申请号：US13337863

    申请日：2011-12-27

    申请人： Jiann-Jyh Huang ,  Chu-Bin Liao ,  Pao-Nien Chen

    发明人： Jiann-Jyh Huang ,  Chu-Bin Liao ,  Pao-Nien Chen

    IPC分类号： A61K31/517 ,  C07D401/12 ,  C07D215/44 ,  A61K31/4706 ,  A61K31/4709 ,  C12N9/99 ,  A61P3/10 ,  A61P13/12 ,  A61P19/02 ,  A61P37/00 ,  A61P35/02 ,  C07D239/94 ,  A61P35/00

    CPC分类号： C12N9/99 ,  C07D239/94 ,  C12Y207/00

    摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRa Rb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.

    摘要翻译： 一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O） R a和R b各自独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所在的氮原子一起 杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。