公开(公告)号：US4713963A

公开(公告)日：1987-12-22

申请号：US879022

申请日：1986-06-26

申请人： Daryl Sharp

发明人： Daryl Sharp

IPC分类号： G01N30/16 ,  G01N30/72 ,  G01N31/08

CPC分类号： G01N30/7206 ,  G01N2030/165 ,  G01N2030/7226 ,  G01N30/728

摘要： A method and device for analyzing samples containing mixtures of organic compounds using vacuum chromatography is disclosed. The method and device are particularly useful for obtaining mass spectra for identification purposes. The method involves passing a sample dissolved in a solvent through a column with a carrier gas and depositing a thin layer of the sample in the interior of a short column. The short column is then attached to an MS interface. The device comprises a combination of a variable molecular separator and a column alignment component. The alignment component may also be used as a direct probe injector. This device and method allow the separation and MS analysis of mixtures of intermediate molecular weight compounds.

摘要翻译： 公开了一种使用真空色谱分析含有有机化合物混合物的样品的方法和装置。 该方法和装置对于获得用于识别目的的质谱特别有用。 该方法包括将溶解在溶剂中的样品通过载体载气柱并将样品的薄层沉积在短柱的内部。 然后将该短列连接到MS接口。 该装置包括可变分子分离器和柱对准组分的组合。 对准部件也可以用作直接探针喷射器。 该装置和方法允许中等分子量化合物的混合物的分离和MS分析。

公开(公告)号：US4654052A

公开(公告)日：1987-03-31

申请号：US748000

申请日：1985-06-24

申请人： Daryl Sharp

发明人： Daryl Sharp

IPC分类号： G01N30/72 ,  B01D15/08

CPC分类号： G01N30/7293

摘要： A method and device for separating trace amounts of relatively large molecules in the gas or vapor state from a low molecular weight gas or vapor is disclosed. The method and device are particularly useful for interfacing a gas or liquid chromatograph to a mass spectrometer. The device comprises an enclosed chamber to which a vacuum system is attached. Two sample transfer columns are inserted through opposite sides in the chamber. The first column has an outer diameter smaller than the inner diameter or bore of the second column and the end of the first column may be moved into the bore of the second column. A second vacuum source is applied to the second transfer column. When a sample mixture in the gas or vapor state passes from the first column into the second column, the fractional split in the bulk or carrier stream between the two vacuum systems is accurately controlled solely by the diameters of the two columns and the extent to which the first column in inserted into the second. Also depending on the depth of insertion the larger trace sample molecules may be caused to preferentially pass into the second column and vacuum system. In general, sample enrichment of a gas stream can be accomplished at the expense of sample recovery. For chromatography/mass spectrometry applications trace sample recovery may be kept at acceptable levels while maintaining high vacuum conditions in the mass spectrometer.

摘要翻译： 公开了一种用于从低分子量气体或蒸汽中分离痕量的气体或蒸气状态较大分子的方法和装置。 该方法和装置对气相色谱仪或液相色谱仪与质谱仪的接口特别有用。 该装置包括一个与真空系统连接的封闭室。 两个样品转移柱通过腔室的相对侧插入。 第一列具有小于第二列的内径或孔的外径，并且第一列的端部可以移动到第二列的孔中。 将第二真空源施加到第二转移柱。 当气体或蒸汽状态的样品混合物从第一塔通到第二塔时，两个真空系统之间的体积或载体流中的分数分裂仅由两列的直径精确地控制， 第一列插入第二列。 另外取决于插入深度，较大的痕量样品分子可以优先进入第二塔和真空系统。 通常，气流的样品富集可以以样品回收为代价。 对于色谱/质谱应用，痕量样品回收率可保持在可接受的水平，同时在质谱仪中保持高真空条件。

公开(公告)号：US4641541A

公开(公告)日：1987-02-10

申请号：US828178

申请日：1986-02-11

申请人： Daryl Sharp

发明人： Daryl Sharp

IPC分类号： G01N30/72

CPC分类号： G01N30/7213 ,  G01N30/7206 ,  G01N30/7293

摘要： A device for sensitive analysis of unknown organic samples is disclosed. The device is particularly useful as an interface between a gas chromatograph and a mass spectrometer which has a high pumping capacity. The device comprises an interface internal to the mass spectrometer which may either be attached directly to an inlet probe inserted into a mass spectrometer or directly to the source body of a mass spectrometer. In both cases, the sample goes directly into the source cavity and an auxiliary vacuum system is not required for sample enrichment. For mass spectrometers with marginal pumping capacity, or when very low source pressures are required, the vacuum system may be augmented by designs which either partially or completely isolate the source and interface exhaust pumping systems from each other.

摘要翻译： 公开了一种用于敏感分析未知有机样品的装置。 该装置特别可用作气相色谱仪和质量分析仪之间的接口，其具有高的泵送能力。 该装置包括质谱仪内部的界面，其可以直接连接到插入质谱仪的入口探针或直接连接到质谱仪的源体上。 在这两种情况下，样品直接进入源腔，并且不需要辅助真空系统用于样品富集。 对于具有边缘泵送能力的质谱仪，或者当需要非常低的源压力时，真空系统可以通过将源和界面排气泵送系统彼此部分或完全隔离的设计来增强。