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1.发明授权Low antigen-dose immunization utilizing overlapping peptides for maximizing T-helper cell 1 (Th1) immunity against a pathogen 有权低抗原剂量免疫利用重叠的肽，以最大限度地提高针对病原体的T辅助细胞1（Th1）免疫公开(公告)号：US08647636B2
公开(公告)日：2014-02-11
申请号：US13602833
申请日：2012-09-04
IPC分类号： A61K39/40 , A61K39/395 , A61K51/00 , A61M36/14
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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2.发明授权Low antigen-dose immunization for maximizing T-helper cell 1 (Th1) immunity against a pathogen 有权低抗原剂量免疫用于最大限度地提高针对病原体的T辅助细胞1（Th1）免疫公开(公告)号：US09107875B2
公开(公告)日：2015-08-18
申请号：US12949559
申请日：2010-11-18
IPC分类号： A61K35/00 , A61K47/00 , A01N61/00 , C12Q1/68 , A61K39/118 , A61K38/10 , A61K38/20 , A61K38/21 , A61K39/00
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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3.发明申请公开(公告)号：US20120328644A1
公开(公告)日：2012-12-27
申请号：US13602833
申请日：2012-09-04
IPC分类号： A61K39/118 , A61P31/04
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
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4.发明申请Low Antigen-dose Immunization for Maximizing T-helper Cell 1 (Th1) Immunity Against a Pathogen 有权低抗原剂量免疫最大化T辅助细胞1（Th1）对病原体的免疫公开(公告)号：US20120009220A1
公开(公告)日：2012-01-12
申请号：US12949559
申请日：2010-11-18
IPC分类号： A61K39/118 , A61P31/04 , A61P37/04 , A61K39/00 , A61K39/02
CPC分类号： A61K39/118 , A61K38/10 , A61K38/2013 , A61K38/217 , A61K39/12 , A61K2039/545 , A61K2039/552 , A61K2039/55511
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and methods is substantially lower than dosages conventionally used in the field. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译： 公开了用于诱导针对疾病的免疫应答的组合物，试剂盒和方法。 在本公开的组合物，试剂盒和方法中所含或使用的抗原剂量基本上低于本领域常规使用的剂量。 组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。 在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。
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