公开(公告)号：US20050101583A1

公开(公告)日：2005-05-12

申请号：US10398924

申请日：2001-10-09

申请人： Robert Stevenson ,  Fraser Kerr ,  Anthony Lane ,  Eve Brazier ,  Philip Hogan ,  David Laffan

发明人： Robert Stevenson ,  Fraser Kerr ,  Anthony Lane ,  Eve Brazier ,  Philip Hogan ,  David Laffan

IPC分类号： C07B61/00 ,  C07J31/00 ,  C07J41/00 ,  C07J75/00 ,  A61K31/56 ,  C07J1/00

CPC分类号： C07J31/006 ,  C07J31/00 ,  Y02P20/55

摘要： A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R2, R3, R4 and R5 are organic groups as defined in the specification, which process comprises aromatisation of a compound of formula (III) where R1, R2, R3, n, X and R5 are as defined in relation to formula (II) and R4′ is a group R4 or a precursor group thereof, and thereafter if necessary or desired, carrying out one or more of the following steps: (i) removing any hydroxy-protecting groups R; (ii) converting a precursor group R4′ to a group R4, or where R4′ is a group R4, converting it to a different such group. Compounds obtained are useful intermediates for example in the preparation of fulvestrant. Novel intermediates are also claimed.

摘要翻译： 制备其中X如说明书中所定义的式（II）的中间体化合物的方法是卤代烷基，烷基，烯基，环烷基，羧基烷基，烷氧基羰基烷基，芳基或芳基烷基; R 2，R 3，R 4和R 5是说明书中定义的有机基团，该方法 包括式（III）化合物的芳构化，其中R 1，R 2，R 3，R 3，n，X和R 5 如式（II）所定义，并且R 4'是基团R 4或其前体基团，然后如果需要或需要， 进行一个或多个以下步骤：（i）除去任何羟基保护基团R; （ii）将前体基团R 4'转化成基团R 4，或其中R 4'是基团R 4 ，将其转换为不同的这样的组。 获得的化合物是例如制备氟维司群的有用的中间体。 还要求新的中间体。

公开(公告)号：US4027609A

公开(公告)日：1977-06-07

申请号：US699764

申请日：1976-06-25

申请人： Alexander Fraser Kerr

发明人： Alexander Fraser Kerr

IPC分类号： D05B27/02 ,  D05B27/08

CPC分类号： D05B27/02

摘要： This disclosure relates to feed mechanisms for sewing machines, particularly industrial sewing machines. A reciprocatory advance motion is imparted to a feed dog means by an eccentric means connected to a driven shaft in the machine and to a feed advance shaft which imparts an oscillating motion to the feed dog means. A feed dog lift means for imparting a lift motion to the feed dog includes an eccentric means also connected to the driven shaft. The mechanisms for imparting advance motion and lift motion to the feed dog are connected to a common fulcrum pin to provide a sturdy and stable mechanism capable of operating at high speeds with minimum noise and vibration. A second feed dog means is provided which has a common advance mechanism and a similar lift mechanism as the first mentioned feed dog means with each of the feed dog means being individually adjustable to provide a differential feed system in which two work feeding elements are adapted to be actuated so as to exert unequal feeding actions on the work, if desired.

摘要翻译： 本公开涉及缝纫机，特别是工业缝纫机的进给机构。 通过连接到机器中的从动轴的偏心装置和向进给爪装置施加摆动运动的进给前进轴将馈送装置赋予往复进动运动。 用于将馈送动作提供给馈送狗的馈线提升装置包括也连接到从动轴的偏心装置。 用于将进给动作提升运动的机构连接到共同的支点销，以提供坚固和稳定的机构，其能够以最小的噪音和振动以高速运行。 提供了第二进给爪装置，其具有与第一所述进给爪装置相同的前进机构和类似的提升机构，其中每个进给爪装置可单独调节以提供差动进给系统，其中两个工作进给元件适于 如果需要，可以对工作施加不均匀的进给动作。