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公开(公告)号：US20110189273A1
公开(公告)日：2011-08-04
申请号：US12959321
申请日：2010-12-02
申请人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
发明人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
CPC分类号： A61K31/13 , A61K9/0002 , A61K9/0004 , A61K9/0053 , A61K9/14 , A61K9/48 , A61K9/4808 , A61K9/4891 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/198
摘要： Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration.
摘要翻译： 描述了夜间施用金刚烷胺以减少用金刚烷胺治疗的患者的睡眠障碍的方法，以及适用于夜间给药的延长释放金刚烷胺的组合物。
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公开(公告)号：US08741343B2
公开(公告)日：2014-06-03
申请号：US12959321
申请日：2010-12-02
申请人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
发明人： Gregory T. Went , Gayatri Sathyan , Kavita Vermani , Gangadhara Ganapati , Michael Coffee , Efraim Shek , Ashok Katdare
CPC分类号： A61K31/13 , A61K9/0002 , A61K9/0004 , A61K9/0053 , A61K9/14 , A61K9/48 , A61K9/4808 , A61K9/4891 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K31/198
摘要： Methods of nighttime administration of amantadine to reduce sleep disturbances in patient undergoing treatment with amantadine are described, as well as compositions of extended release amantadine that are suitable for nighttime administration.
摘要翻译： 描述了夜间施用金刚烷胺以减少用金刚烷胺治疗的患者的睡眠障碍的方法，以及适用于夜间给药的延长释放金刚烷胺的组合物。
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公开(公告)号：US20180362570A1
公开(公告)日：2018-12-20
申请号：US16012004
申请日：2018-06-19
IPC分类号： C07H19/048 , A61K31/706 , A61K45/06
摘要： The disclosure provides derivatives of both the oxidized form and the reduced form of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The NR and NAR derivatives have improved stability and bioavailability compared to NR and NAR, and can increase cellular NAD+ levels and improve mitochondrial function. Therefore, the NR and NAR derivatives are useful for treating mitochondrial diseases, mitochondria-related diseases and conditions, and other disorders and conditions.
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