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    Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same
    3.
    发明授权
    Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same 失效
    吡啶鎓醛缩酶类胆碱酯酶激活剂的新型前药衍生物及其使用方法

    公开(公告)号：US3962447A

    公开(公告)日：1976-06-08

    申请号：US603612

    申请日：1975-08-11

    申请人： Takeru Higuchi ,  Nicolae S. Bodor ,  Efraim Shek

    发明人： Takeru Higuchi ,  Nicolae S. Bodor ,  Efraim Shek

    IPC分类号： C07D211/82 ,  A61K31/44

    CPC分类号： C07D211/82

    摘要： There is provided, novel pro-drug forms of pyridinium aldoxime type cholinesterase reactivators, namely, dihydropyridinium aldoximes, having the formula: ##SPC1##Wherein R represents a member selected from the group consisting of an alkyl (C.sub.1 -C.sub.4) group, a ##SPC2##Group, a ##SPC3##Group, ##SPC4##Group, and a ##SPC5##Wherein Z represents a member selected from the group consisting of a --CH.sub.2 --CH.sub.2 -- group, a --CH.sub.2 --O--CH.sub.2 -- group, a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- group, and a --CH.sub.2 O--CH.sub.2 --CH.sub.2 --O--CH.sub.2 -- group; wherein R.sub.1 represents a member selected from the group consisting of a hydrogen atom, a methyl group, an acyl group and a ##EQU1## group; and wherein X.sup.- represents an anion derived from a pharmaceutically acceptable acid addition salt.These compounds are useful in reactivating cholinesterase, inhibited following exposure to and/or ingestion of conventional anti-cholinesterase agents, especially in the brain.

    摘要翻译： 提供了吡啶鎓醛肟型胆碱酯酶再活化剂的新型前药形式，即二氢吡啶鎓醛肟，具有下式：