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公开(公告)号：US20080131424A1
公开(公告)日：2008-06-05
申请号：US11856949
申请日：2007-09-18
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US20120177654A1
公开(公告)日：2012-07-12
申请号：US13335974
申请日：2011-12-23
IPC分类号： A61K39/395 , A61P19/00 , A61P11/00 , A61P25/00 , A61P17/06 , A61P1/00 , A61K38/02 , A61P3/04
CPC分类号： C07K16/2866 , A61K38/1793 , A61K39/3955 , A61K2039/505 , A61P29/00 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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公开(公告)号：US07455836B2
公开(公告)日：2008-11-25
申请号：US09851230
申请日：2001-05-08
CPC分类号： C07K16/2866 , A61K31/00 , A61K38/1793 , A61K39/3955 , A61K2039/505 , C07K16/241 , C07K16/243 , C07K2317/73 , C07K2317/76 , G01N33/5047
摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。
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