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7 条记录 (耗时 0.011 秒)

    Pteridine compounds
    1.
    发明授权
    Pteridine compounds 失效
    蝶啶化合物

    公开(公告)号：US4042589A

    公开(公告)日：1977-08-16

    申请号：US621661

    申请日：1975-10-14

    申请人： Hamish Christopher Swan Wood ,  Kyuji Ohta

    发明人： Hamish Christopher Swan Wood ,  Kyuji Ohta

    IPC分类号： C07D239/50 ,  C07D475/04

    CPC分类号： C07D239/50

    摘要： Novel pteridines of formula (I), ##STR1## wherein R is an optionally substituted phenoxyalkyl group, and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group or R.sup.1 and R.sup.2, together with the carbon atom, in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure, and their method of preparation.The above compounds have bacteriostatic activity.

    摘要翻译： 式（I），（I）的新型蝶啶，其中R是任选取代的苯氧基烷基，R 1和R 2相同或不同，各自是低级烷基或R 1和R 2与碳原子一起， 在蝶啶环结构中，形成在蝶啶环结构外具有4-6个碳原子的螺环烷基环系及其制备方法。

    Substantially pure diastereoisomers of tetrahydrofolate derivatives
    2.
    发明授权
    Substantially pure diastereoisomers of tetrahydrofolate derivatives 失效
    四氢叶酸衍生物的基本纯的非对映异构体

    公开(公告)号：US06500829B1

    公开(公告)日：2002-12-31

    申请号：US08426458

    申请日：1995-04-18

    申请人： Hamish Christopher Swan Wood ,  Colin James Suckling ,  Lilias G. Rees

    发明人： Hamish Christopher Swan Wood ,  Colin James Suckling ,  Lilias G. Rees

    IPC分类号： A61K31519

    CPC分类号： C07D475/04

    摘要： The present invention related to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present invention provides a process for the preparation of a desired substantially pure (6R or 6S) diastereoisomer of a derivative of tetrahydrofolic acid or salt or ester. The process comprises the steps of: attaching a chiral auxiliary group at either N-5 or N-10 of a mixture of 6R and 6S diastereoisomers of tetrahydrofolic acid, separating the new diastereoisomers, recovering the desired new diastereoisomer (6R or 6S) corresponding to the desired (6R or 6S) diastereoisomer, and converting the substantially pure new diastereoisomer recovered into the corresponding diastereoisomer.

    摘要翻译： 本发明涉及制备基本上纯的四氢叶酸衍生物的非对映异构体和这种非对映异构体的用途。 更具体地，本发明提供了制备四氢叶酸或其盐或酯衍生物的所需基本上纯的（6R或6S）非对映异构体的方法。 该方法包括以下步骤：将六氢叶酸的6R和6S非对映异构体的混合物的N-5或N-10的手性辅助基团连接，分离新的非对映异构体，回收对应于新的非对映异构体的所需新的非对映异构体（6R或6S） 所需的（6R或6S）非对映异构体，并将基本上纯的新的非对映异构体转化成相应的非对映异构体。

    6-Spirocycloalkylamino 5-nitropyrimidines
    3.
    发明授权
    6-Spirocycloalkylamino 5-nitropyrimidines 失效
    6-螺环烷基氨基-5-硝基嘧啶

    公开(公告)号：US3963719A

    公开(公告)日：1976-06-15

    申请号：US383698

    申请日：1973-07-30

    申请人： Hamish Christopher Swan Wood ,  Irene Stirling

    发明人： Hamish Christopher Swan Wood ,  Irene Stirling

    IPC分类号： C07C29/147 ,  C07C207/04 ,  C07D239/48 ,  C07D475/04 ,  C07D239/22

    CPC分类号： C07D239/48 ,  C07C207/04 ,  C07C29/147 ,  C07D475/04 ,  C07C2101/14

    摘要： Novel pteridines of formula (I), ##SPC1##wherein R is a lower alkyl group, optionally substituted with a hydroxy group and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group having together at least 3 carbon atoms or R.sup.1 and R.sup.2, together with the carbon atom in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure, and their method of preparation.The above compounds have bacteriostatic activity.

    摘要翻译： 式（I）的新型蝶啶，其中R是任选被羟基取代的低级烷基，R 1和R 2相同或不同，并且各自是具有至少3个碳原子的低级烷基，或者R 1和R 2， 与蝶啶环结构中的碳原子一起形成在蝶啶环结构外具有4-6个碳原子的螺环烷基环系及其制备方法。

    Optically active compounds
    5.
    发明授权
    Optically active compounds 失效
    光活性化合物

    公开(公告)号：US06849628B2

    公开(公告)日：2005-02-01

    申请号：US10228820

    申请日：2002-08-27

    申请人： Hamish Christopher Swan Wood ,  Colin James Suckling ,  Lilias Gilmour Rees

    发明人： Hamish Christopher Swan Wood ,  Colin James Suckling ,  Lilias Gilmour Rees

    IPC分类号： A61K31/505 ,  A61K31/519 ,  A61P35/00 ,  C07D475/04

    CPC分类号： C07D475/04

    摘要： The present invention relates to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present invention provides a process for the preparation of a desired substantially pure (6R or 6S) diastereoisomer of a derivative of tetrahydrofolic acid or salt or ester. The process comprises the steps of: attaching a chiral auxiliary group at either N-5 or N-10 of a mixture of 6R and 6S diastereoisomers of tetrahydrofolic acid, separating the new diastereoisomers, recovering the desired new diastereoisomer (6R or 6S) corresponding to the desired (6R or 6S) diastereoisomer, and converting the substantially pure new diastereoisomer recovered into the corresponding diastereoisomer.

    摘要翻译： 本发明涉及制备基本上纯的四氢叶酸衍生物的非对映异构体和这种非对映异构体的用途。 更具体地，本发明提供了制备四氢叶酸或其盐或酯衍生物的所需基本上纯的（6R或6S）非对映异构体的方法。 该方法包括以下步骤：将六氢叶酸的6R和6S非对映异构体的混合物的N-5或N-10的手性辅助基团连接，分离新的非对映异构体，回收对应于新的非对映异构体的所需新的非对映异构体（6R或6S） 所需的（6R或6S）非对映异构体，并将基本上纯的新的非对映异构体转化成相应的非对映异构体。

    5-Nitropyrimidines
    7.
    发明授权
    5-Nitropyrimidines 失效
    5-硝基嘧啶

    公开(公告)号：US3933820A

    公开(公告)日：1976-01-20

    申请号：US383699

    申请日：1973-07-30

    申请人： Hamish Christopher Swan Wood ,  Kyuji Ohta

    发明人： Hamish Christopher Swan Wood ,  Kyuji Ohta

    IPC分类号： C07D239/48 ,  C07D239/50 ,  C07D475/04 ,  C07D239/22

    CPC分类号： C07D239/48 ,  C07D239/50 ,  C07D475/04 ,  Y02P20/55

    摘要： Novel pteridines of formula (I), ##SPC1##wherein R is an optionally substituted phenoxyalkyl group, and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group or R.sup.1 and R.sup.2, together with the carbon atom in the pteridine ring structure, form a spirocycloalkyl ring system having 4 to 6 carbon atoms outside the pteridine ring structure,And their method of preparation.The above compounds have bacteriostatic activity.

    摘要翻译： 式（I）的新型蝶啶，其中R是任选取代的苯氧基烷基，R 1和R 2相同或不同，各自为低级烷基或R 1和R 2与蝶啶环结构中的碳原子一起形成 在蝶啶环结构外具有4-6个碳原子的螺环烷基环系统及其制备方法。