公开(公告)号：US20240327326A1

公开(公告)日：2024-10-03

申请号：US17619922

申请日：2021-11-17

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Guangqin LI ,  QINGLIN LIU

IPC: C07C45/62 ,  B01J23/89 ,  B01J31/18 ,  B01J37/00 ,  B01J37/02 ,  B01J37/03 ,  B01J37/04 ,  B01J37/06 ,  B01J37/34 ,  C07C29/141 ,  C07C201/12 ,  C07C209/36

CPC classification number: C07C45/62 ,  B01J23/8906 ,  B01J23/8913 ,  B01J23/892 ,  B01J31/18 ,  B01J37/009 ,  B01J37/0236 ,  B01J37/035 ,  B01J37/04 ,  B01J37/06 ,  B01J37/343 ,  C07C29/141 ,  C07C201/12 ,  C07C209/36 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2231/763 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2601/16

Abstract: The present disclosure relates to the technical field of molecular biology, and in particular to a method for preparing a Pt-based alloy/MOFs catalyst with high hydrogenation selectivity, and a preparation method thereof. The present disclosure prepares a Pt-based alloy/MOFs structure with Pt alloy particles uniformly supported on the surface of MOFs in one step through a simple solvothermal method, the preparation method of the present disclosure is simple, the reaction environment is not harsh and does not require a special atmosphere. The resulting product has a unique structure, with small metal particles, uniform distribution and not easy to lose, and it will not affect the catalytic activity of the metal. In terms of catalytic performance, the obtained Pt alloy/MOFs catalyst can catalytically hydrogenate cinnamaldehyde under normal temperature and pressure, and has excellent performance. In addition, the catalyst can also catalyze the selective hydrogenation of 3-nitrostyrene, catalyze the dehydrogenation of tetrahydroquinoline, which proves that the catalyst of the present disclosure has a wide range of applications.

公开(公告)号：US20240294455A1

公开(公告)日：2024-09-05

申请号：US18571275

申请日：2022-06-16

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.

Inventor： Stefan GLÖGGLER ,  Sergey KORCHAK ,  Anil P. JATAP ,  Philip SAUL ,  Denis MOLL

IPC: C07C67/31 ,  C07B59/00 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08

CPC classification number: C07C67/31 ,  C07B59/001 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08 ,  C07B2200/05

Abstract: The present invention relates to a method for preparing a compound suitable for signal enhanced magnetic resonance imaging comprising the steps of vinylating a mono-, di- or tricarboxylic acid comprising a moiety -Q-Z with Q being O or N and Z being a protecting group by using vinyl acetate, cleaving Z, and if Z has not already been converted into an alcohol upon cleavage, converting Q into an alcohol either by using nitrite or by converting Q into bromine followed by hydrolysis yielding a vinyl hydroxy ester. The compounds used may be partly or fully deuterated. Furthermore, the present invention relates to a vinyl hydroxy ester as well as an intermediate of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediate is partly or fully deuterated.

公开(公告)号：US20240239730A1

公开(公告)日：2024-07-18

申请号：US18618449

申请日：2024-03-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16

CPC classification number: C07C29/92 ,  A61K31/045 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/78 ,  C07C29/86 ,  C07C29/88 ,  C07C67/14 ,  C07C201/12 ,  C07C201/16 ,  C07B2200/07 ,  C07C2601/16

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US11820724B2

公开(公告)日：2023-11-21

申请号：US17296544

申请日：2020-09-10

Applicant: ACCELA CHEMBIO CO., LTD. ,  QIDONG ACCELA CHEMBIO CO., LTD.

Inventor： Yang Liu ,  Duoqing Xue ,  Yong Wu ,  Lihuang Chen ,  Lianhua Zhai

IPC: C07C201/08 ,  C07C201/12

CPC classification number: C07C201/08 ,  C07C201/12

Abstract: The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.

公开(公告)号：US11819837B2

公开(公告)日：2023-11-21

申请号：US18150909

申请日：2023-01-06

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter Baratta ,  Salvatore Baldino ,  Steven Giboulot

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

CPC classification number: B01J31/2452 ,  B01J31/182 ,  B01J31/189 ,  B01J31/2433 ,  C07B41/02 ,  C07C29/14 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07F15/0053 ,  B01J2231/641 ,  B01J2531/0244 ,  B01J2531/821 ,  B01J2531/825 ,  C07C2602/10 ,  C07C29/143 ,  C07C33/22 ,  C07C29/14 ,  C07C33/22 ,  C07C29/143 ,  C07C33/24 ,  C07C29/14 ,  C07C33/46 ,  C07C29/14 ,  C07C33/30 ,  C07C29/145 ,  C07C33/22 ,  C07C29/145 ,  C07C35/36 ,  C07C29/145 ,  C07C33/20 ,  C07C41/26 ,  C07C43/23 ,  C07C29/145 ,  C07C33/26 ,  C07C29/145 ,  C07C31/125 ,  C07C201/12 ,  C07C205/19

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US11795138B2

公开(公告)日：2023-10-24

申请号：US17572688

申请日：2022-01-11

Applicant: Fujian Yongjing Technology Co., Ltd

Inventor： Changyue Zhou ,  Hongjun Du ,  Wenting Wu

IPC: C01B21/083 ,  C07C253/30 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07B39/00 ,  C01C3/00

CPC classification number: C07C253/30 ,  C01B21/0832 ,  C01B21/0835 ,  C01C3/004 ,  C07B39/00 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07C253/30 ,  C07C255/10 ,  C07C303/22 ,  C07C309/80 ,  C07C67/307 ,  C07C69/63 ,  C07C201/12 ,  C07C205/12 ,  C07C253/30 ,  C07C255/50 ,  C07C17/06 ,  C07C25/13

Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.

公开(公告)号：US11691135B2

公开(公告)日：2023-07-04

申请号：US17071713

申请日：2020-10-15

Applicant: King Fahd University of Petroleum & Minerals ,  Saudi Arabian Oil Company

Inventor： Bassam El Ali ,  Waseem Mansour ,  Mohammed Fettouhi

IPC: C07C45/49 ,  C07C201/12 ,  C07D307/58 ,  C07F15/06 ,  B01J31/22 ,  C07C45/50 ,  C07F15/00

CPC classification number: B01J31/2273 ,  C07C45/50 ,  C07C201/12 ,  C07D307/58 ,  C07F15/006 ,  B01J2231/321 ,  C07C2601/14

Abstract: This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.

公开(公告)号：US20230145668A1

公开(公告)日：2023-05-11

申请号：US18150909

申请日：2023-01-06

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter BARATTA ,  Salvatore BALDINO ,  Steven GIBOULOT

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

CPC classification number: B01J31/2452 ,  C07B41/02 ,  C07F15/0053 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/182 ,  B01J31/189 ,  B01J31/2433 ,  C07C2602/10 ,  B01J2231/641 ,  B01J2531/0244 ,  B01J2531/821 ,  B01J2531/825

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20180244596A1

公开(公告)日：2018-08-30

申请号：US15558978

申请日：2016-03-18

Applicant: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVEDA

Inventor： Wesley A. CHALIFOUX ,  Kyle C. SPROUL ,  Wenlong YANG

IPC: C07C43/205 ,  C07C205/06 ,  C07C25/22 ,  C07C211/50 ,  C07F7/08 ,  C07C15/38 ,  C07C22/08 ,  C07D333/08 ,  C07C309/68 ,  C08G61/10 ,  C07C25/24 ,  C07C41/20 ,  C07C201/12 ,  C07C209/68 ,  C07C5/09 ,  C07C17/354 ,  C07C303/30

CPC classification number: C07C43/2055 ,  C07C5/09 ,  C07C13/28 ,  C07C15/38 ,  C07C17/354 ,  C07C22/08 ,  C07C25/22 ,  C07C25/24 ,  C07C41/20 ,  C07C43/21 ,  C07C201/12 ,  C07C205/06 ,  C07C209/68 ,  C07C211/50 ,  C07C303/30 ,  C07C309/68 ,  C07C2601/14 ,  C07C2603/50 ,  C07C2603/54 ,  C07D333/08 ,  C07D333/18 ,  C07F7/0805 ,  C08G61/10 ,  C08G2261/1414 ,  C08G2261/148 ,  C08G2261/228 ,  C08G2261/312

Abstract: Disclosed herein are embodiments of aryl compounds and polymers thereof that are made using methods that do not require harsh conditions or expensive reagents. The methods disclosed herein utilize precursor compounds that can be polymerized to form polycyclic aromatic hydrocarbons and polymers, such as carbon-based polymers like nanostructures (e.g., graphene or graphene-like nanoribbons).

公开(公告)号：US20180186721A1

公开(公告)日：2018-07-05

申请号：US15861020

申请日：2018-01-03

Applicant: The Governors of the University of Alberta

Inventor： Rylan LUNDGREN ,  Patrick MOON

IPC: C07C67/32 ,  C07C69/614 ,  C07C69/38 ,  C07F5/02

CPC classification number: C07C67/32 ,  C07C67/343 ,  C07C69/38 ,  C07C69/614 ,  C07C201/12 ,  C07C231/12 ,  C07C303/40 ,  C07C315/04 ,  C07C2523/72 ,  C07C2527/055 ,  C07C2527/122 ,  C07C2527/26 ,  C07C2601/02 ,  C07C2601/14 ,  C07D213/55 ,  C07D213/61 ,  C07D213/64 ,  C07D295/185 ,  C07D307/91 ,  C07F5/025 ,  C07F5/027 ,  C07F7/081 ,  C07F9/4046 ,  C07C69/65 ,  C07C69/612 ,  C07C69/738 ,  C07C69/734 ,  C07C69/76 ,  C07C69/63 ,  C07C235/34 ,  C07C311/21 ,  C07C233/65 ,  C07C233/66 ,  C07C233/74 ,  C07C233/11 ,  C07C317/46 ,  C07C317/44 ,  C07C205/56

Abstract: Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.