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1.发明授权
公开(公告)号：US06022858A
公开(公告)日：2000-02-08
申请号：US121386
申请日：1998-07-23
申请人： Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim , Christensen Thorkild , Per Balschmidt
发明人： Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim , Christensen Thorkild , Per Balschmidt
摘要： A pharmaceutical formulation comprising a growth hormone pretreated with zinc and optionally lysine or calcium ions shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译： 包含用锌和任选的赖氨酸或钙离子预处理的生长激素的药物制剂显示出非常高的抗磷酸化，氧化和肽键切割的稳定性。 产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。
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公开(公告)号：US5849704A
公开(公告)日：1998-12-15
申请号：US458386
申请日：1995-06-02
摘要： A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.
摘要翻译： 包含生长激素和组氨酸或组氨酸衍生物作为添加剂或缓冲物质的药物制剂显示出非常高的抗肽脱离，氧化和切割的稳定性。 产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。 在组氨酸或其衍生物存在下生长激素的结晶产生比已知方法具有更高纯度的晶体的较高产率。
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公开(公告)号：US5849700A
公开(公告)日：1998-12-15
申请号：US458385
申请日：1995-06-02
摘要： A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.
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公开(公告)号：US5977069A
公开(公告)日：1999-11-02
申请号：US827178
申请日：1992-01-28
IPC分类号： A61K38/27 , A61K9/08 , A61K31/195 , A61K47/02 , A61K47/16 , A61K47/18 , A61K47/26 , A61K47/42 , A61P5/02 , A61K38/00 , A61K9/50 , A61K38/24
CPC分类号： A61K38/27 , A61K47/183
摘要： A pharmaceutical preparation comprising a growth hormone and asparagine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature.
摘要翻译： 包含生长激素和天冬酰胺作为添加剂或缓冲物质的药物制剂表现出非常高的抵抗脱氨基化，氧化和肽键切割的稳定性。 产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。
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公开(公告)号：US5705482A
公开(公告)日：1998-01-06
申请号：US372635
申请日：1995-01-13
申请人： Thorkild Christensen , Per Balschmidt , Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim
发明人： Thorkild Christensen , Per Balschmidt , Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim
CPC分类号： A61K38/27
摘要： A pharmaceutical formulation comprising a growth hormone and Leu-His-Leu as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译： 包含生长激素和Leu-His-Leu作为添加剂或缓冲物质的药物制剂显示出非常高的抗肽脱离，氧化和切割的稳定性。 产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。
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公开(公告)号：US5654278A
公开(公告)日：1997-08-05
申请号：US455886
申请日：1995-05-31
IPC分类号： A61K38/27 , A61K38/00 , A61K31/195
CPC分类号： A61K38/27
摘要： A pharmaceutical formulation comprising a growth hormone and leucine shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译： 包含生长激素和亮氨酸的药物制剂显示出非常高的抗磷酸化，氧化和肽键切割的稳定性。 产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。
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