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公开(公告)号：US5451393A
公开(公告)日：1995-09-19
申请号：US207533
申请日：1994-03-07
CPC分类号： A61K49/049 , A61K49/0423 , A61K49/0428 , B82Y5/00
摘要： An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver or spleen. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.
摘要翻译： 一种X射线对比组合物，其包含基本上由非放射性结晶有机x射线造影剂组成的颗粒，其具有以足以保持有效平均粒径小于400nm的量吸附在其表面上的表面改性剂，以及 其药学上可接受的载体可用于x射线诊断医学成像方法。 药剂可以递送到特定的组织或流体部位，例如血液池，肝脏或脾脏。 在涉及静脉内给药的一个实施方案中，优选的组合物提供血液池的有效成像非常长的时间。
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公开(公告)号：US5318767A
公开(公告)日：1994-06-07
申请号：US928244
申请日：1992-08-10
CPC分类号： A61K49/049 , A61K49/0423 , A61K49/0428 , B82Y5/00
摘要： An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than 400 nm, and a pharmaceutically acceptable carrier therefor is useful in x-ray diagnostic medical imaging methods. The agents can be delivered to a specific tissue or fluid site, for example, the blood pool, liver or spleen. In one embodiment involving intravenous administration, preferred compositions provide effective imaging of the blood pool for remarkably long times.
摘要翻译： 一种X射线对比组合物，其包含基本上由非放射性结晶有机x射线造影剂组成的颗粒，其具有以足以保持有效平均粒径小于400nm的量吸附在其表面上的表面改性剂，以及 其药学上可接受的载体可用于x射线诊断医学成像方法。 药剂可以递送到特定的组织或流体部位，例如血液池，肝脏或脾脏。 在涉及静脉内给药的一个实施方案中，优选的组合物提供血液池的有效成像非常长的时间。
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