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    Bioadhesive nanoparticulate compositions having cationic surface stabilizers
    5.
    发明授权
    Bioadhesive nanoparticulate compositions having cationic surface stabilizers 有权
    具有阳离子表面稳定剂的生物粘附纳米颗粒组合物

    公开(公告)号：US07288267B2

    公开(公告)日：2007-10-30

    申请号：US10004808

    申请日：2001-12-07

    Applicant: H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    Inventor： H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    IPC: A61K9/14 ,  A61K9/16

    CPC classification number: A01N25/12 ,  A01N25/24 ,  A01N25/30 ,  A61K8/0241 ,  A61K8/36 ,  A61K8/416 ,  A61K8/49 ,  A61K8/553 ,  A61K8/63 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8147 ,  A61K8/8182 ,  A61K9/113 ,  A61K9/145 ,  A61K9/146 ,  A61K2800/413 ,  A61K2800/612 ,  A61K2800/614 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00

    Abstract: Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

    Abstract translation: 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。

    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
    6.
    发明授权
    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的成膜材料中碘苯氧基烷烃和碘苯基醚的组成

    公开(公告)号：US5326553A

    公开(公告)日：1994-07-05

    申请号：US12171

    申请日：1993-02-02

    Applicant: Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    Inventor： Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    IPC: A61K49/04 ,  A61K31/075

    CPC classification number: A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p-- (CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylin a pharmaceutically acceptable carrier.

    Abstract translation: 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; 任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基羰基氧基取代的C 1 -C 25烷基，环烷基或卤代低级烷基，（CR 1 R 2）p - （CR3 = CR4）mQ，或（CR1R2）pC 3BOND CQ; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; Q为药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

    Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
    7.
    发明授权
    Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one 失效
    含有1-十二烷基 - 氮杂环庚烷-2-酮的渗透性局部药物组合物

    公开(公告)号：US4557934A

    公开(公告)日：1985-12-10

    申请号：US506275

    申请日：1983-06-21

    Applicant: Eugene R. Cooper

    Inventor： Eugene R. Cooper

    IPC: A61K9/06 ,  A61K9/70 ,  A61K31/52 ,  A61K31/57 ,  A61K47/08 ,  A61K47/22 ,  A01N59/26 ,  A61K33/42

    CPC classification number: A61K47/22 ,  A61K31/57 ,  A61K9/0014 ,  Y10S514/947

    Abstract: Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C.sub.3 -C.sub.4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

    Abstract translation: 公开了含有药物活性剂和渗透促进剂1-十二烷基氮杂环庚烷-2-酮的改进的局部药物组合物。 该试剂与某些C3-C4二醇或1-取代的氮杂环烷基-2-酮组合使用。 该组合物提供所选择的药物活性剂的显着经皮和经皮递送。 还公开了对所选择的活性物质，系统地或局部反应的某些病理学和病症的治疗方法。

    Topical anesthetic for rapid local anesthesia
    8.
    发明授权
    Topical anesthetic for rapid local anesthesia 失效
    局部麻醉用于快速局部麻醉

    公开(公告)号：US08759391B2

    公开(公告)日：2014-06-24

    申请号：US12015113

    申请日：2008-01-16

    Applicant: David M. Cohen ,  Eugene R Cooper

    Inventor： David M. Cohen ,  Eugene R Cooper

    IPC: A61K31/24

    CPC classification number: A61K31/24 ,  A61K9/0014

    Abstract: A topical anesthetic for rapid local anesthesia is provided. The topical anesthetic includes an anesthetic, volatile and non-volatile solvents, and a thickener. In addition, a method is taught for applying the topical anesthetic to the face of a patient without occlusion. The anesthetic is applied topically to an area for injection such that the dermatological procedure (cosmetic injections) can be performed in fifteen minutes.

    Abstract translation: 提供了用于快速局部麻醉的局部麻醉剂。 局部麻醉剂包括麻醉剂，挥发性和非挥发性溶剂和增稠剂。 此外，教导了一种将局部麻醉剂施用于患者面部而不堵塞的方法。 将麻醉剂局部施用于注射区域，使得皮肤病学程序（化妆品注射）可以在十五分钟内进行。

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