公开(公告)号：US20110250196A1

公开(公告)日：2011-10-13

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US08999931B2

公开(公告)日：2015-04-07

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K38/09 ,  A61K47/48 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。