公开(公告)号：US20160355593A1

公开(公告)日：2016-12-08

申请号：US14993265

申请日：2016-01-12

申请人： Celldex Therapeutics Inc.

发明人： Tibor Keler ,  Michael Endres ,  Lizhen He ,  Venky Ramakrishna

IPC分类号： C07K16/28 ,  A61K39/00 ,  C07K14/59

CPC分类号： C07K16/2851 ,  A61K39/0006 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/572 ,  A61K2039/6056 ,  C07K14/59 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2318/10 ,  C07K2319/00 ,  C07K2319/33 ,  Y02A50/401 ,  Y02A50/412 ,  Y02A50/469

摘要： The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.

摘要翻译： 本发明提供新的抗体疫苗缀合物及其使用方法诱导细胞毒性T细胞（CTL）应答。 在具体的实施方案中，疫苗缀合物包括与抗甘露糖受体（MR）抗体连接的人绒毛膜促性腺激素β亚基（βhCG）抗原。

公开(公告)号：US20160030146A1

公开(公告)日：2016-02-04

申请号：US14814148

申请日：2015-07-30

申请人： Iowa State University Research Foundation, Inc.

发明人： Douglas E. Jones ,  Matthew Brewer ,  Balaji Narasimhan ,  John Jackman

IPC分类号： A61D1/02 ,  A61K39/00 ,  A61K47/32 ,  A61K47/42 ,  A61K47/02 ,  A61K9/00 ,  A61K47/12

CPC分类号： A61D1/025 ,  A61K9/0024 ,  A61K39/0005 ,  A61K39/0006 ,  A61K39/12 ,  A61K47/42 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/6031 ,  A61M5/00 ,  C12N2710/16734

摘要： This document provides vaccine delivery devices and methods for vaccinating an animal (e.g., a mammal). For example, vaccine delivery devices that include a container having one or more openings, a vaccine depot located within the container, and a diffusion barrier located within the container in a manner such that material (e.g., an antigenic vaccine component) within the vaccine depot must pass through the diffusion barrier before reaching one of the openings are provided.

摘要翻译： 本文件提供用于疫苗接种动物（例如哺乳动物）的疫苗递送装置和方法。 例如，包括具有一个或多个开口的容器，位于容器内的疫苗储存库的疫苗递送装置和位于容器内的扩散阻挡层，使得疫苗库内的材料（例如，抗原性疫苗组分） 必须通过扩散屏障才能到达其中一个开口。

公开(公告)号：US09149520B2

公开(公告)日：2015-10-06

申请号：US13420082

申请日：2012-03-14

申请人： John Walker

发明人： John Walker

IPC分类号： A61K39/395 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39591 ,  A61K39/0006 ,  A61K39/39 ,  A61K47/183 ,  A61K2039/55577 ,  A61K2039/55583

摘要： An adjuvant composition which comprises an anionic macromolecule component particularly an ionic polysaccharide such as DEAE-dextran, and a saponin component, particularly an immunostimulating complex component. Immunogenic compositions comprising an immunogen and this adjuvant composition are also disclosed together with methods of use thereof.

摘要翻译： 一种佐剂组合物，其包含阴离子大分子组分，特别是离子多糖如DEAE-葡聚糖和皂苷组分，特别是免疫刺激复合物组分。 还公开了包含免疫原和该佐剂组合物的免疫原性组合物及其使用方法。

公开(公告)号：US20150190491A1

公开(公告)日：2015-07-09

申请号：US14662482

申请日：2015-03-19

申请人： Centro de Ingenieria Genetica Y Biotecnologia

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin—releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US08999931B2

公开(公告)日：2015-04-07

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K38/09 ,  A61K47/48 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US20150093406A1

公开(公告)日：2015-04-02

申请号：US14570133

申请日：2014-12-15

申请人： Imaxio

发明人： Judith DEL CAMPO ASCARATEIL ,  Imene TURKI HANI ,  Fergal HILL

IPC分类号： C07K14/47 ,  C07K14/005 ,  C12N7/00 ,  C07K14/31 ,  C07K7/06

CPC分类号： C07K14/4703 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0006 ,  A61K39/002 ,  A61K39/04 ,  A61K39/085 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6031 ,  A61K2039/627 ,  A61K2039/64 ,  C07K7/06 ,  C07K14/005 ,  C07K14/31 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/73 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16134 ,  Y02A50/489

摘要： The present application is related to a modified protein comprising a protein having a coiled coil domain and a peptide having the sequence such as shown in SEQ ID NO 1: ZXBBBBZ that is linked to the coiled coil domain wherein: Z is any amino acid or is absent; X is any amino acid; B is an arginine (R) or a lysine (K). Said modified protein is in particular an antigen or a carrier protein, associated to an antigen. This modified protein has an increased affinity for negatively charged polymers such as nucleic acids or heparin, and shows an increased immunogenicity.

摘要翻译： 本申请涉及包含具有卷曲螺旋结构域的蛋白质和具有如序列号1：ZXBBBBZ所示的序列的肽的修饰蛋白质，所述序列与卷曲螺旋结构域连接，其中：Z是任何氨基酸或是 缺席; X是任何氨基酸; B是精氨酸（R）或赖氨酸（K）。 所述修饰的蛋白质特别是与抗原相关的抗原或载体蛋白质。 该修饰的蛋白质对带负电荷的聚合物例如核酸或肝素具有增加的亲和力，并且显示增加的免疫原性。

公开(公告)号：US08741303B2

公开(公告)日：2014-06-03

申请号：US13587249

申请日：2012-08-16

申请人： Michael Kerin McNamara

发明人： Michael Kerin McNamara

IPC分类号： A61K39/385 ,  C07K7/06 ,  C07K14/33 ,  C07K14/59 ,  A61K31/721

CPC分类号： A61K47/4833 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/646 ,  A61K2039/55583 ,  A61K2039/6037

摘要： The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behavior patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

摘要翻译： 本发明一般涉及免疫原性LHRH组合物，更具体地涉及包含至少五个氨基酸的LHRH C-末端片段的免疫原性LHRH组合物。 本发明尤其可用作改变动物的生育力和行为模式的预防和/或治疗剂，实现家畜生产增益如增加生长，降低饲料转化率或控制不想要的感官特征 或治疗生殖器官疾病。

公开(公告)号：US08367067B2

公开(公告)日：2013-02-05

申请号：US12488485

申请日：2009-06-19

申请人： David Jackson ,  Weiguang Zeng

发明人： David Jackson ,  Weiguang Zeng

IPC分类号： A61K39/00

CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K39/0006 ,  A61K2039/543 ,  A61K2039/6018 ,  A61K2039/6068 ,  C07K19/00

摘要： The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

公开(公告)号：US20120328639A1

公开(公告)日：2012-12-27

申请号：US13587249

申请日：2012-08-16

申请人： Michael Kerin McNamara

发明人： Michael Kerin McNamara

IPC分类号： A61K39/05 ,  A61P15/00 ,  A61P35/00

CPC分类号： A61K47/4833 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/646 ,  A61K2039/55583 ,  A61K2039/6037

摘要： The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

摘要翻译： 本发明一般涉及免疫原性LHRH组合物，更具体地涉及包含至少五个氨基酸的LHRH C-末端片段的免疫原性LHRH组合物。 本发明尤其可用作改变动物的生育力和行为模式的预防和/或治疗剂，实现家畜生产增益如增加生长，降低饲料转化率或控制不想要的感官特征 或治疗生殖器官疾病。

公开(公告)号：US08012932B2

公开(公告)日：2011-09-06

申请号：US11572453

申请日：2005-07-22

申请人： Gary R. Klinefelter

发明人： Gary R. Klinefelter

IPC分类号： A61K38/00

CPC分类号： A61K35/52 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0006 ,  A61K2039/54 ,  C07K14/47 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  G01N33/689 ,  G01N33/6893 ,  G01N2800/367 ,  Y10S424/811 ,  Y10S530/806 ,  Y10S530/852

摘要： Oral, topical and injectable contraceptives, which are based on sperm protein 22 kDa (SP22) polypeptides and antibodies and infertility diagnostics are provided.

摘要翻译： 提供基于精子蛋白22kDa（SP22）多肽和抗体和不孕症诊断的口服，局部和可注射的避孕药。