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公开(公告)号：US20100111965A1
公开(公告)日：2010-05-06
申请号：US12445109
申请日：2007-10-11
申请人： James Johnston , Shane Olwill , Jill Brown , Nuala Morgan , Thomas Jaquin , Christopher Scott
发明人： James Johnston , Shane Olwill , Jill Brown , Nuala Morgan , Thomas Jaquin , Christopher Scott
IPC分类号： A61K39/395 , A61K31/7088 , C07K16/00 , A61P35/00 , C12Q1/68
CPC分类号： C12N15/1136 , A61K39/39558 , C07K16/22 , C07K2317/56 , C07K2317/73 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要： The invention provides a method of treating neoplastic disease in a subject, said method comprising the simultaneous, sequential or separate, administration to said subject of an effective amount of (i) an inhibitor of a first EGF, e.g. HB-EGF and (ii) an inhibitor of a second EGF, e.g. AREG. Also described are novel synergistic combinations of EGF inhibitors with topoisomerase inhibitors which attenuate tumour cell growth. Further described are novel anti AREG antibodies.
摘要翻译： 本发明提供一种治疗受试者的肿瘤疾病的方法，所述方法包括向所述受试者施用有效量的（i）第一EGF的抑制剂，例如， HB-EGF和（ii）第二EGF的抑制剂，例如。 AREG。 还描述了EGF抑制剂与拓扑异构酶抑制剂的新的协同组合，其减弱肿瘤细胞生长。 进一步描述的是新的抗AREG抗体。
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公开(公告)号：US20120100968A1
公开(公告)日：2012-04-26
申请号：US13317501
申请日：2011-10-20
申请人： James Tilton , Jill Brown , Douglas James Wille
发明人： James Tilton , Jill Brown , Douglas James Wille
IPC分类号： A63B21/00
CPC分类号： A63B21/1645 , A63B21/0442 , A63B21/068 , A63B21/151 , A63B21/4043 , A63B22/001 , A63B2022/0038 , A63B2022/0041
摘要： Improved strap type exercising devices comprising an attaching band having an attaching member for attachment to a door knob or the like and two D rings supported by the band together with a pair of straps each extending slidably through a respective one of said D rings and having handles formed at each end of said straps with ankle straps attached to each of said straps adjacent one end thereof, said straps being movable individually or in unison, as desired.
摘要翻译： 改进的带式锻炼装置包括具有附接构件以用于附接到门把手等的附接带和由带支撑的两个D环以及一对带，每个带可滑动地延伸穿过所述D环中的相应一个，并且具有手柄 在所述带的每个端部处形成有踝带，踝带附接到每个所述带的邻近其一端，所述带可以根据需要单独地或一致地移动。
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