公开(公告)号：US08416416B2

公开(公告)日：2013-04-09

申请号：US12745444

申请日：2007-11-29

申请人： Zheng Zheng ,  Yuhang Wan ,  Xin Zhao ,  Jinsong Zhu ,  Jiangfeng Fan

发明人： Zheng Zheng ,  Yuhang Wan ,  Xin Zhao ,  Jinsong Zhu ,  Jiangfeng Fan

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： The invention provides an SPR measuring method and a measuring system thereof. According to the measuring method, first, a linear-polarized coherent broadband pulsed light beam is incident onto a surface of a sample under detection of a SPR sensing device to cause reflection; next, a time-domain monotonous chirp is performed on the incident coherent broadband pulsed light and/or the SPR reflected light; finally, the time-domain monotonically chirped SPR reflected light beam is detected, and information of the SPR effect is obtained according to the detected signal. According to the invention, the spectrum detection method used in conventional slow wavelength interrogation is converted into the high-speed real-time detection of time-domain pulse shape signals. Thus, the procedure of the SPR reaction may be monitored closely, and dynamical curves with very high time resolution may be obtained, in that case, fast biochemical reaction procedures may be monitored. As each part of the measuring system may remain fixed during the measurement, a compact, miniature and portable system may be realized. The interrogation part of the sensing system is easy-to-realize, of low cost and compatible with various SPR devices and components.

摘要翻译： 本发明提供一种SPR测量方法及其测量系统。 根据测量方法，首先，线性偏振相干宽带脉冲光束在SPR感测装置的检测下入射到样品的表面上以引起反射; 接下来，对入射相干宽带脉冲光和/或SPR反射光执行时域单调啁啾; 最后，检测到时域单调啁啾的SPR反射光束，并根据检测到的信号获得SPR效应的信息。 根据本发明，在常规慢波询问中使用的频谱检测方法被转换成时域脉冲形状信号的高速实时检测。 因此，可以密切监测SPR反应的过程，并且可以获得具有非常高的时间分辨率的动力学曲线，在这种情况下，可以监测快速的生化反应程序。 由于测量系统的每个部分在测量期间都可能保持固定，因此可以实现紧凑，微型和便携式系统。 传感系统的询问部分易于实现，成本低廉，与各种SPR设备和组件兼容。

公开(公告)号：US20110285986A1

公开(公告)日：2011-11-24

申请号：US13125382

申请日：2008-10-28

申请人： Kun Wang ,  Jinsong Zhu ,  Zheng Zheng ,  Jiangfeng Fan

发明人： Kun Wang ,  Jinsong Zhu ,  Zheng Zheng ,  Jiangfeng Fan

IPC分类号： G01B11/26

CPC分类号： G01N21/553

摘要： The present disclosure provides a detection system for acquiring the SPR angle, including a modulatable SPR sensor to be detected; an incident light source apparatus; a photoelectric detector; a narrowband filter system; a modulated signal source for generating an alternating current signal that is used to modulate said modulatable SPR sensor; and a data processing system for recording the corresponding relationship between the incident angle and the intensity of the filtered reflected light and further obtaining the resonance angle of said modulatable SPR sensor. The present disclosure also provides a corresponding detection method for acquiring the SPR angle.

摘要翻译： 本公开提供了一种用于获取SPR角度的检测系统，包括可检测的可调节SPR传感器; 入射光源装置; 光电检测器 窄带滤波系统; 用于产生用于调制所述可调节SPR传感器的交流信号的调制信号源; 以及数据处理系统，用于记录入射角和滤光反射光的强度之间的对应关系，并进一步获得所述可调节SPR传感器的共振角。 本公开还提供了用于获取SPR角度的相应检测方法。

公开(公告)号：US20100321697A1

公开(公告)日：2010-12-23

申请号：US12745444

申请日：2007-11-29

申请人： Zheng Zheng ,  Yuhang Wan ,  Xin Zhao ,  Jinsong Zhu ,  Jiangfeng Fan

发明人： Zheng Zheng ,  Yuhang Wan ,  Xin Zhao ,  Jinsong Zhu ,  Jiangfeng Fan

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： The invention provides an SPR measuring method and a measuring system thereof. According to the measuring method, first, a linear-polarized coherent broadband pulsed light beam is incident onto a surface of a sample under detection of a SPR sensing device to cause reflection; next, a time-domain monotonous chirp is performed on the incident coherent broadband pulsed light and/or the SPR reflected light; finally, the time-domain monotonically chirped SPR reflected light beam is detected, and information of the SPR effect is obtained according to the detected signal. According to the invention, the spectrum detection method used in conventional slow wavelength interrogation is converted into the high-speed real-time detection of time-domain pulse shape signals. Thus, the procedure of the SPR reaction may be monitored closely, and dynamical curves with very high time resolution may be obtained, in that case, fast biochemical reaction procedures may be monitored. As each part of the measuring system may remain fixed during the measurement, a compact, miniature and portable system may be realized. The interrogation part of the sensing system is easy-to-realize, of low cost and compatible with various SPR devices and components.

摘要翻译： 本发明提供一种SPR测量方法及其测量系统。 根据测量方法，首先，线性偏振相干宽带脉冲光束在SPR感测装置的检测下入射到样品的表面上以引起反射; 接下来，对入射相干宽带脉冲光和/或SPR反射光执行时域单调啁啾; 最后，检测到时域单调啁啾的SPR反射光束，并根据检测到的信号获得SPR效应的信息。 根据本发明，在常规慢波询问中使用的频谱检测方法被转换成时域脉冲形状信号的高速实时检测。 因此，可以密切监测SPR反应的过程，并且可以获得具有非常高的时间分辨率的动力学曲线，在这种情况下，可以监测快速的生化反应程序。 由于测量系统的每个部分在测量期间都可能保持固定，因此可以实现紧凑，微型和便携式系统。 传感系统的询问部分易于实现，成本低廉，与各种SPR设备和组件兼容。

公开(公告)号：US08836931B2

公开(公告)日：2014-09-16

申请号：US13125382

申请日：2008-10-28

申请人： Kun Wang ,  Jinsong Zhu ,  Zheng Zheng ,  Jiangfeng Fan

发明人： Kun Wang ,  Jinsong Zhu ,  Zheng Zheng ,  Jiangfeng Fan

IPC分类号： G01B11/26 ,  G01N21/55

CPC分类号： G01N21/553

摘要： The present disclosure provides a detection system for acquiring the SPR angle, including a modulatable SPR sensor to be detected; an incident light source apparatus; a photoelectric detector; a narrowband filter system; a modulated signal source for generating an alternating current signal that is used to modulate said modulatable SPR sensor; and a data processing system for recording the corresponding relationship between the incident angle and the intensity of the filtered reflected light and further obtaining the resonance angle of said modulatable SPR sensor. The present disclosure also provides a corresponding detection method for acquiring the SPR angle.

摘要翻译： 本公开提供了一种用于获取SPR角度的检测系统，包括可检测的可调节SPR传感器; 入射光源装置; 光电检测器 窄带滤波系统; 用于产生用于调制所述可调节SPR传感器的交流信号的调制信号源; 以及数据处理系统，用于记录入射角和滤光反射光的强度之间的对应关系，并进一步获得所述可调节SPR传感器的共振角。 本公开还提供了用于获取SPR角度的相应检测方法。

公开(公告)号：US20110037981A1

公开(公告)日：2011-02-17

申请号：US12676672

申请日：2007-09-06

申请人： Jinsong Zhu ,  Xinlong Xu ,  Jiangfeng Fan ,  Kun Wang ,  Chen Wang ,  Anthony D. Piscopio

发明人： Jinsong Zhu ,  Xinlong Xu ,  Jiangfeng Fan ,  Kun Wang ,  Chen Wang ,  Anthony D. Piscopio

IPC分类号： G01J4/04 ,  H01L27/144 ,  H01L31/0232

CPC分类号： G01N21/553

摘要： A sensor chip based on the WCSPR effect and an array thereof are disclosed. The sensor chip is a multilayer structure comprising a substrate, a dielectric waveguide layer (26) disposed on the substrate and a first metal layer (27) disposed on the dielectric waveguide layer (26), wherein parameters of physical properties of the dielectric waveguide layer (26) are tunable.

摘要翻译： 公开了一种基于WCSPR效应的传感器芯片及其阵列。 传感器芯片是包括基板，设置在基板上的电介质波导层（26）和布置在电介质波导层（26）上的第一金属层（27）的多层结构，其中电介质波导层 （26）是可调的。