公开(公告)号：US20120021447A1

公开(公告)日：2012-01-26

申请号：US13143070

申请日：2009-12-30

申请人： Joao Garcia Da Fonseca ,  Nuno Alexandre Esteves Reis ,  Robert Burger

发明人： Joao Garcia Da Fonseca ,  Nuno Alexandre Esteves Reis ,  Robert Burger

IPC分类号： C12Q1/37

CPC分类号： B01L3/50273 ,  B01L2300/0803 ,  B01L2300/0861 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688

摘要： Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.

摘要翻译： 用于响应于驱动力产生离散流体的装置，例如用于响应于恒定驱动力产生离散流的离心微流体装置。 该装置包括用于响应于驱动力以流入速率向离散结构供应液体的供应结构。 离散化结构被成形为在响应于驱动力通过出口以分流液体分配液体之前，界定离散化结构填充有从供给结构流出的液体的出口和水平。 该装置被布置成使得离离离结构的流出速率大于进入离散化结构的流入速率，从而周期性地排空离散化结构以从出口产生离散的流。 这些装置可用于液体混合，例如稀释样品，如血浆样品。