公开(公告)号：US20240351030A1

公开(公告)日：2024-10-24

申请号：US18634178

申请日：2024-04-12

申请人： TDK Corporation

发明人： Rakesh Sethi

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L2300/0627 ,  B01L2300/12 ,  B01L2400/0475

摘要： An example microfluidic device includes a first substrate, a second substrate, a set of electrodes, a set of piezoelectric components, a support, a set of piezoelectric actuators coupled to the support, and a polymer component. In the example device, the set of electrodes and the set of piezoelectric components are coupled to a surface of the second substrate. The support is configured to support at least one of the first substrate and the second substrate. The set of piezoelectric actuators is configured to adjust positioning of the support. The polymer is adapted to removably couple the first and second substrates such that a microfluidic channel is formed between the first and second substrates while the first and second substrates are coupled by the polymer.

公开(公告)号：US12123840B2

公开(公告)日：2024-10-22

申请号：US18504091

申请日：2023-11-07

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Alexandra Ros ,  Daihyun Kim ,  Austin Echelmeier ,  Jorvani Cruz Villarreal ,  Ana Egatz-Gomez ,  Sebastian Quintana

IPC分类号： G01N23/20025 ,  B01L3/00 ,  B01L3/02 ,  B33Y80/00

CPC分类号： G01N23/20025 ,  B01L3/0241 ,  B01L3/50273 ,  B33Y80/00 ,  B01L2300/0867 ,  G01N2223/602

摘要： Methods and systems are provided for serial femtosecond crystallography for reducing the vast amount of waste of injected crystals practiced with traditional continuous flow injections. A micrometer-scale 3-D printed water-in-oil droplet generator device includes an oil phase inlet channel, an aqueous phase inlet channel, a droplet flow outlet channel, and two embedded non-contact electrodes. The inlet and outlet channels are connected internally at a junction. The electrodes comprise gallium metal injected within the 3-D printed device. Voltage across the electrodes generates water-in-oil droplets, determines a rate for a series of droplets, or triggers a phase shift in the droplets. An external trigger generates the droplets based on the frequency of an XFEL utilized in droplet detection, thereby synchronizing a series of droplets with x-ray pulses for efficient crystal detection. The generated droplets can be coupled to an SFX with XFEL experiment compatible with common liquid injector such as a GDVN.

公开(公告)号：US20240335833A1

公开(公告)日：2024-10-10

申请号：US18738051

申请日：2024-06-09

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： Sebastian KIBLER ,  Henry LEISTNER ,  Karl NEUMEIER ,  Thomas THALHOFER ,  Kristjan AXELSSON ,  Daniel ANHEUER ,  Martin RICHTER ,  Johannes HÄFNER ,  Claudia DURASIEWICZ ,  Christian WALD ,  Agnes BUSSMANN ,  Lorenz GRÜNERBEL

IPC分类号： B01L3/00 ,  G01N27/22

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  G01N27/22 ,  B01L2200/143

摘要： The inventive concept described herein concerns a microfluidic component, comprising a membrane actuator with a membrane element and an actuator element for deflecting the membrane element. A signal generation device is configured to generate an electric control signal having a time-variant signal curve for controlling the membrane actuator, by which the actuator element actuates the membrane element. A signal processing device is configured to detect, during operation of the microfluidic component, an influence on the temporal signal curve of the control signal, caused by one or more external influencing factors, and, on the basis of this influence on the temporal signal curve, to identify and/or classify at least one causal external influencing factor.

公开(公告)号：US20240326045A1

公开(公告)日：2024-10-03

申请号：US18622503

申请日：2024-03-29

申请人： Donaldson Company, Inc.

发明人： Jinxiang Zhou ,  Raymond S. Cleveland ,  Daniel P. Little ,  Benjamin C. Druecke ,  Matthew P. Goertz ,  Aflal Rahmathullah

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/0487

摘要： The present application discloses a cassette assembly including an inlet cassette plate, an outlet cassette plate, and a separation layer disposed therebetween. The inlet cassette plate defines an inlet flow path and an inlet channel extending therefrom. The outlet cassette plate is configured to be arranged in a stack with the inlet cassette plate and defines an outlet flow path and an outlet channel extending therefrom. The separation layer extends from a first lateral end to a second lateral end. The inlet flow path is configured to be in fluid communication with the outlet flow path through the separation layer. The inlet channel defines an effective inlet surface area of the separation layer and the outlet channel defines an effective outlet surface area of the separation layer. The effective inlet surface area defines a first width towards the first lateral end and a second width towards the second lateral end.

公开(公告)号：US20240319179A1

公开(公告)日：2024-09-26

申请号：US18393445

申请日：2023-12-21

申请人： Ghassem Amoabediny ,  Mohammadreza Farrokhnia ,  Mohammad Arjmand ,  Mohammad Ebrahimi

发明人： Ghassem Amoabediny ,  Mohammadreza Farrokhnia ,  Mohammad Arjmand ,  Mohammad Ebrahimi

IPC分类号： G01N33/543 ,  B01L3/00

CPC分类号： G01N33/5438 ,  B01L3/50273 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0861 ,  B01L2300/16 ,  B01L2400/0487 ,  G01N2333/62 ,  G01N2333/705 ,  G01N2333/765

摘要： A nano-biosensor system for early detection of diabetes includes a plurality of electrochemical immunosensors and a multiplexed microfluidic system that may be connected in fluid communication with the plurality of electrochemical immunosensors. A working electrode of each electrochemical immunosensor includes a base gold surface, a porous layer of polyaniline conductive polymer deposited onto the base gold surface, gold nanoparticles deposited inside pores of the porous layer of polyaniline conductive polymer, L-glutathione reduced linkers attached from respective thiol group ends of the L-glutathione reduced linkers to the gold nanoparticles, and a specific antigen connected to carboxyl group ends of the L-glutathione reduced linkers. The specific antigen includes at least one of recombinant insulin protein, insulin receptor protein, and recombinant glial fibrillary acidic protein.

公开(公告)号：US20240307872A1

公开(公告)日：2024-09-19

申请号：US18276587

申请日：2022-01-19

申请人： SHENZHEN YHLO BIOTECH CO., LTD.

发明人： Chungen QIAN ,  Ming HUANG ,  Bifeng LIU ,  Peng CHEN ,  Yujin XIAO ,  Kunhui HU

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688

摘要： The present invention relates to a microfluidic chip, a reagent output structure thereof comprising a reagent storage chamber, a first centrifugal-force flow channel and a time delay unit. The time delay unit comprises a first diverting flow channel, a capillary-force flow channel, a second diverting flow channel and a second centrifugal-force flow channel. The first centrifugal-force flow channel extends away from the centre of rotation. The other end of the first diverting flow channel is in communication with one end of the capillary-force flow channel, the capillary-force flow channel extends towards the centre of rotation, the other end of the capillary-force flow channel is in communication with one end of the second diverting flow channel, the other end of the second diverting flow channel is in communication with the second centrifugal-force flow channel, and the second centrifugal-force flow channel extends away from the centre of rotation.

公开(公告)号：US12085528B2

公开(公告)日：2024-09-10

申请号：US16311619

申请日：2015-05-14

申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Ki-Ho Han ,  Jin-Ho Kim

IPC分类号： G01N27/30 ,  B01L3/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14

CPC分类号： G01N27/30 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  C12M1/34 ,  C12M1/42 ,  C12M47/04 ,  G01N15/10 ,  B01L3/0241 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1024 ,  G01N2015/1029 ,  G01N15/1459

摘要： An apparatus and method for separating single cells. The apparatus includes: a fluid channel having an upper panel, a lower panel, and a flow path formed therebetween that is configured to convey a sample including a single cell; a single cell measuring unit including first and second electrodes provided on the fluid channel in a predetermined spaced relationship for applying electrical signals to the sample in the flow path, and a detection electrode provided between the first and second electrodes to detect the single cell in the sample in the flow path, such that the single cell measuring unit applies the electrical signals to the sample in the flow path, detects the electrical signals of the sample, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode.

公开(公告)号：US20240278238A1

公开(公告)日：2024-08-22

申请号：US18651704

申请日：2024-05-01

申请人： MICO BIOMED CO., LTD.

发明人： Hee Yeong JANG ,  Yong Hee KIM ,  Tae Eun KIM

IPC分类号： B01L3/00 ,  B01L7/00

CPC分类号： B01L3/50273 ,  B01L7/52 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/18 ,  B01L2400/0487

摘要： The present invention provides a plunger that is inserted into a syringe to move solution while reciprocating, the plunger comprising a porous sintered polymer filter layer that swells when in contact with solution to block the moving of the solution and air. The solution-moving module using the plunger of the present invention has the effect of moving an elastic fluid such as air out of the syringe, and allowing only solution to move.

公开(公告)号：US20240269680A1

公开(公告)日：2024-08-15

申请号：US18627417

申请日：2024-04-04

申请人： Biofire Defense, LLC

发明人： Kirk Max Ririe ,  David E. Jones ,  Christopher Paul Pasko ,  Anson Cole Chamberlain ,  Derek David ,  Aaron Wernerehl ,  Jonathan Allen Bruns

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC分类号： B01L7/525 ,  B01L3/50273 ,  C12Q1/686 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1816 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0481

摘要： Instruments, methods, and kits are disclosed for performing fast thermocycling.

公开(公告)号：US12053774B2

公开(公告)日：2024-08-06

申请号：US17185177

申请日：2021-02-25

申请人： The General Hospital Corporation

发明人： Robert Granier ,  Ramin Haghgooie ,  Ken Kotz ,  Anne C. Petrofsky ,  Ronald G. Tompkins

IPC分类号： G01N1/00 ,  B01L3/00 ,  G01N15/01 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/53 ,  G01N21/64 ,  G01N21/78 ,  G01N35/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/359 ,  G01N21/532 ,  G01N21/6486 ,  G01N21/78 ,  G01N35/00029 ,  G01N35/00871 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0689 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0861 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/12 ,  G01N15/1459 ,  G01N2021/6493 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00881 ,  G01N2201/024 ,  G01N2201/06113 ,  G01N2201/062

摘要： A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.