公开(公告)号：US07033571B2

公开(公告)日：2006-04-25

申请号：US10701053

申请日：2003-11-03

申请人： Anna Gutowska ,  Karol J. Krzyminski

发明人： Anna Gutowska ,  Karol J. Krzyminski

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/2027 ,  A61K47/32

摘要： A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.

公开(公告)号：US06660247B1

公开(公告)日：2003-12-09

申请号：US09603730

申请日：2000-06-23

申请人： Anna Gutowska ,  Karol J. Krzyminski

发明人： Anna Gutowska ,  Karol J. Krzyminski

IPC分类号： A61K4900

CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/2027 ,  A61K47/32

摘要： A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.

摘要翻译： 公开了能够在暴露于多个环境刺激的临界最小值时胶凝的聚合物溶液。 聚合物溶液可以是在体内使用的水溶液，并且如果至少一种刺激低于或超出临界最小值的范围，则能够使凝胶化反转。 聚合物水溶液可以在工业或制药环境中使用。 在医疗环境中，聚合物水溶液具有用于递送到特定身体部位的化学或放射性同位素治疗剂。 该方法的主要优点是单独暴露于一种环境刺激物不会引起凝胶化，从而使治疗剂能够通过身体传导相对较长距离而没有凝胶化。