公开(公告)号：US06814951B1

公开(公告)日：2004-11-09

申请号：US09318080

申请日：1999-05-25

申请人： Geoffrey M. Thiele ,  Thomas L. McDonald ,  Dean J. Tuma ,  Lynell W. Klassen ,  Michael F. Sorrell

发明人： Geoffrey M. Thiele ,  Thomas L. McDonald ,  Dean J. Tuma ,  Lynell W. Klassen ,  Michael F. Sorrell

IPC分类号： A61K4900

CPC分类号： C07K16/44 ,  C07K14/76 ,  C07K16/18

摘要： A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.

公开(公告)号：US06770259B2

公开(公告)日：2004-08-03

申请号：US10002359

申请日：2001-11-02

申请人： Alan P. Carpenter, Jr.

发明人： Alan P. Carpenter, Jr.

IPC分类号： A61K4900

CPC分类号： A61K51/12 ,  A61K51/0497

摘要： The present invention provides novel diagnostic compositions comprising a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, diagnostic kits comprising such compositions, and methods of concurrent imaging in a mammal comprising administering a radiolabeled LTB4 binding agent and a radiolabeled perfusion imaging agent, and concurrently detecting the radiolabeled LTB4 binding agent bound at the LTB4 receptor and the radiolabeled perfusion imaging agent.

摘要翻译： 本发明提供了包含放射性标记的LTB4结合剂和放射性标记的灌注成像剂的新型诊断组合物，包含这种组合物的诊断试剂盒，以及在哺乳动物中同时成像的方法，包括施用放射性标记的LTB4结合剂和放射性标记的灌注成像剂， 检测在LTB4受体和放射性标记的灌注成像剂上结合的放射性标记的LTB4结合剂。

公开(公告)号：US06743412B2

公开(公告)日：2004-06-01

申请号：US09947783

申请日：2001-09-07

申请人： Thomas D. Harris ,  Milind Rajopadhye

发明人： Thomas D. Harris ,  Milind Rajopadhye

IPC分类号： A61K4900

CPC分类号： C07D401/14 ,  A61K49/0002 ,  A61K49/04 ,  A61K49/085 ,  A61K49/10 ,  A61K49/223 ,  A61K51/0497 ,  C07D401/12

摘要： The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.

摘要翻译： 本发明描述了新的下式化合物：可用于癌症的诊断和治疗，对患者肿瘤成像的方法，以及治疗患者癌症的方法。 本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。 本发明还提供可用于成像动脉粥样硬化，再狭窄，心脏缺血和心肌再灌注损伤的新型化合物。 本发明还提供了可用于治疗类风湿性关节炎的新化合物。 药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。 可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

公开(公告)号：US06740305B1

公开(公告)日：2004-05-25

申请号：US09958438

申请日：2001-10-09

申请人： Alfred M. Ajami

发明人： Alfred M. Ajami

IPC分类号： A61K4900

CPC分类号： A61K51/1206 ,  A61K49/0004

摘要： Methods of measuring gastric emptying time comprising providing to a patient a meal comprising a breath test food additive substrate, wherein the substrate is a linear or cyclic acyl aminoacid peptidomimetic that includes a radioactive or non-radioactively labeled carbon atom; having the patient digest the meal so that the carbon labeled nutrients therein are absorbed in the small intestine and metabolized to labeled CO2; and, at periodic intervals, detecting the level of labeled CO2 in breath samples taken from the patient to determine the rate of gastric emptying are disclosed.

摘要翻译： 测量胃排空时间的方法，包括向患者提供包含呼吸测试食品添加剂底物的膳食，其中所述底物是包括放射性或非放射性标记的碳原子的线性或环状酰基氨基酸模拟物; 使患者消化膳食，使其中标记有碳的营养物质被吸收在小肠中并代谢成标记的CO 2; 并且周期性地间隔地检测从患者抽取的呼吸样品中标记的CO 2水平以确定胃排空的速率。

公开(公告)号：US06680046B1

公开(公告)日：2004-01-20

申请号：US09419114

申请日：1999-10-15

申请人： Egisto Boschetti

发明人： Egisto Boschetti

IPC分类号： A61K4900

CPC分类号： A61K9/1635 ,  A61K47/6927

摘要： The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present, invention relates to a process for producing the polyvinylalcbhol microspheres.

摘要翻译： 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及一种生产聚乙烯基苯乙醇微球的方法。

公开(公告)号：US06656448B1

公开(公告)日：2003-12-02

申请号：US09783249

申请日：2001-02-14

申请人： Alan P. Carpenter, Jr. ,  Milind Rajopadhye

发明人： Alan P. Carpenter, Jr. ,  Milind Rajopadhye

IPC分类号： A61K4900

CPC分类号： A61K49/00 ,  A61K38/00 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/10 ,  A61K49/223 ,  A61K51/0497 ,  C07F9/6527 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06191

摘要： Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties;a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to the diagnostic metal. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in diagnosis of diseases associated with MMPs.

摘要翻译： 因此，本发明描述了包含诊断金属和化合物的诊断剂，其中所述化合物包含：1-10个靶向部分;螯合剂; 和靶向部分和螯合剂之间的0-1个连接基团; 其中靶向部分是基质金属蛋白酶抑制剂; 并且其中螯合剂能够与诊断金属共轭。 本发明还提供本发明化合物，试剂盒及其在诊断与MMP相关的疾病中的用途的新组合物。

公开(公告)号：US06627407B2

公开(公告)日：2003-09-30

申请号：US09782709

申请日：2001-02-13

申请人： Francis A. Ennis

发明人： Francis A. Ennis

IPC分类号： A61K4900

CPC分类号： G01N33/505

摘要： The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) contacting antigen presenting cells in culture with a vaccine composition selected from among the group of vaccine compositions, thereby, if one or more of the antigens or nucleic acid molecules can be taken up and processed by the antigen presenting cells, producing one or more processed antigens; (2) contacting the antigen presenting cells with T cells under conditions sufficient for the T cells to respond to one or more of the processed antigens; (3) determining whether the T cells respond to one or more of the processed antigens; whereby if the T cells respond to one or more of the processed antigens, then the vaccine composition stimulates a T cell response; and (4) repeating steps (1), (2) and (3) with each vaccine composition in the group, thereby identifying vaccine compositions which stimulate a T cell response; and, if one or more of the vaccine compositions stimulates a T cell response, (5) selecting at least one vaccine composition which stimulates a T cell response for assessment in one or more animals and/or human subjects.

摘要翻译： 本发明涉及用于测定疫苗组合物的能力的体外方法，其包含一种或多种抗原或编码一种或多种抗原以刺激T细胞应答的核酸分子。 在一个实施方案中，该方法包括以下步骤：（1）使培养物中的抗原呈递细胞与选自一组疫苗组合物的疫苗组合物接触，由此，如果可以摄取一种或多种抗原或核酸分子 并由抗原呈递细胞处理，产生一种或多种加工抗原; （2）在足以使T细胞响应于一种或多种经处理的抗原的条件下使抗原呈递细胞与T细胞接触; （3）确定T细胞是否对一种或多种经处理的抗原起反应; 由此如果T细胞响应于一种或多种经处理的抗原，则疫苗组合物刺激T细胞应答; 和（4）与组中的每种疫苗组合物重复步骤（1），（2）和（3），从而鉴定刺激T细胞应答的疫苗组合物; 并且如果一种或多种疫苗组合物刺激T细胞应答，（5）选择至少一种刺激T细胞应答以在一种或多种动物和/或人类受试者中进行评估的疫苗组合物。

公开(公告)号：US06599495B1

公开(公告)日：2003-07-29

申请号：US09643476

申请日：2000-08-22

申请人： Paul R. Ervin, Jr.

发明人： Paul R. Ervin, Jr.

IPC分类号： A61K4900

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C07K2317/74 ,  C07K2319/00 ,  C12Q1/6886 ,  G01N33/57415 ,  G01N33/57488

摘要： A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated mammastatin.

摘要翻译： 编码哺乳动物抑制素（特异性乳腺细胞生长抑制剂）的核酸序列。 Mammastatin由单个核酸序列编码，其非活性，非磷酸化形式的近似分子量为44kDa。 正常的乳腺细胞表达具有近似分子量为53kDa和49kDa的功能性磷酸化形式。 转移性乳腺细胞根本不表达母乳喂养，或不表达53kDa或49kDa磷酸化形式。 乳腺癌细胞通过施用磷酸化的哺乳动物抑制其生长。

公开(公告)号：US06596257B2

公开(公告)日：2003-07-22

申请号：US09746485

申请日：2000-12-22

申请人： Bruce Bryan

发明人： Bruce Bryan

IPC分类号： A61K4900

CPC分类号： A61K49/0013 ,  A61K47/6851 ,  C12Q1/66 ,  G01N33/533 ,  G01N33/574 ,  G01N33/581 ,  G01N33/582

摘要： Kits containing the diagnostic systems and diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal.

公开(公告)号：US06540981B2

公开(公告)日：2003-04-01

申请号：US09732917

申请日：2000-12-11

申请人： Jo Klaveness ,  Bjorn Fuglass ,  Pål Rongved ,  Edvin Johannesen ,  Paul Mark Hendrichs ,  Wolfgang Hans Heinrich Gunther ,  Edward Richard Bacon ,  John Luke Toner ,  Gregory Lynn McIntire ,  Vinay C. Desai

发明人： Jo Klaveness ,  Bjorn Fuglass ,  Pål Rongved ,  Edvin Johannesen ,  Paul Mark Hendrichs ,  Wolfgang Hans Heinrich Gunther ,  Edward Richard Bacon ,  John Luke Toner ,  Gregory Lynn McIntire ,  Vinay C. Desai

IPC分类号： A61K4900

CPC分类号： B82Y5/00 ,  A61K49/001 ,  A61K49/0015 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0078 ,  A61K49/0082 ,  A61K49/0084 ,  A61K49/0433 ,  A61K49/0461 ,  A61K49/0466 ,  A61K49/0485 ,  A61K49/223 ,  A61K49/227

摘要： The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.

摘要翻译： 本发明涉及在体内光成像中使用颗粒材料作为造影剂。