公开(公告)号：US20070167386A1

公开(公告)日：2007-07-19

申请号：US10565974

申请日：2004-07-28

申请人： Kinya Otsu ,  Kazuhiko Nishida ,  Osamu Yamaguchi ,  Yoshiharu Higuchi ,  Hidenori Ichijo

发明人： Kinya Otsu ,  Kazuhiko Nishida ,  Osamu Yamaguchi ,  Yoshiharu Higuchi ,  Hidenori Ichijo

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K39/395 ,  A61K38/45

CPC分类号： A61K31/7105 ,  A61K31/711 ,  A61K45/06 ,  G01N33/6893 ,  G01N2333/912

摘要： The present invention provides a drug for at least one of prevention and treatment of cardiac failure capable of suppressing cardiac depression and the onset of cardiac failure in ventricular remodeling, and a method for screening the drug. The drug for at least one of prevention and treatment of cardiac failure of the present invention contains a compound that inhibits a functional expression of ASK1 protein in a cardiomyocyte as an active ingredient, and a method for screening a drug for at least one of prevention and treatment of cardiac failure of the present invention includes selecting a medicinal component for at least one of prevention and treatment of cardiac failure from a drug candidate compound by using inhibition of a functional expression of ASK1 protein as an indication. As shown in FIG. 1, if ASK1 protein is removed, for example, the ventricle dilation can be attenuated in ventricular remodeling after myocardial infarction, pressure loading, or the like, which makes it possible to prevent and treat cardiac failure.

摘要翻译： 本发明提供了用于预防和治疗能够抑制心脏抑制的心脏衰竭和心室重构中的心力衰竭的发生中的至少一种的药物，以及用于筛选药物的方法。 用于本发明的心脏衰竭的预防和治疗中的至少一种的药物含有抑制作为活性成分的心肌细胞中ASK1蛋白质的功能性表达的化合物，以及用于筛选药物的方法中的至少一种， 本发明的心力衰竭的治疗包括通过使用ASK1蛋白的功能性表达的抑制作为指示，从药物候选化合物中选择预防和治疗心力衰竭中的至少一种的药物成分。 如图所示。 1，如果除去ASK1蛋白质，例如，可以在心肌梗塞，加压负荷等之后的心室重塑中减弱心室扩张，这使得可以预防和治疗心力衰竭。

公开(公告)号：US4222771A

公开(公告)日：1980-09-16

申请号：US5762

申请日：1979-01-23

申请人： Teishiro Oda ,  Takashi Daikoku ,  Teruo Yukitoshi ,  Kazuhiko Nishida

发明人： Teishiro Oda ,  Takashi Daikoku ,  Teruo Yukitoshi ,  Kazuhiko Nishida

IPC分类号： C22C38/00 ,  C22C38/22 ,  C22C39/02

CPC分类号： C22C38/22

摘要： High chromium steel, for use at high temperature, of a mixed structure containing ferrite and 0.02-0.09% C, less than 1.0% Si, 0.1-2.0% Mn, 7.0-13.0% chromium, 1.2-3.0% Mo, and the rest being iron and the usual impurities, or further adding aluminum in an amount less than 0.1% to said composition, or further adding 0.001-0.1% boron and less than 0.1% Ti necessary to cause the boron to act effectively, said steel being heated at temperatures lower than about 1050.degree. C. to prevent the oxidation of the steel.

摘要翻译： 含有铁素体和0.02-0.09％C，小于1.0％Si，0.1-2.0％Mn，7.0-13.0％铬，1.2-3.0％Mo的混合结构的高铬钢，其余为高铬钢 或者进一步向所述组合物中加入小于0.1％的铝，或者进一步加入0.001-0.1％的硼和小于0.1％的Ti以使硼有效地起作用，所述钢被加热到 温度低于约1050℃，以防止钢的氧化。