公开(公告)号：US06608043B1

公开(公告)日：2003-08-19

申请号：US09936245

申请日：2001-09-07

申请人： Isao Serizawa ,  Keisei Maekawa ,  Janos Illes ,  Erzsebet Neszmeli

发明人： Isao Serizawa ,  Keisei Maekawa ,  Janos Illes ,  Erzsebet Neszmeli

IPC分类号： A01N4304

CPC分类号： A61K31/728 ,  A61K33/30 ,  A61K47/61 ,  Y10S514/825 ,  A61K31/715 ,  A61K2300/00

摘要： The present invention provides an agent for treatment of arthritic diseases such as rheumatoid arthritis that has for its active ingredient a complex of hyaluronic acid and zinc. This complex synergistically inhibits proliferation of synovial cells and suppresses matrix metalloproteinase MMP-9, which is produced by synovial cells, as compared with its constituents, hyaluronic acid and zinc, alone.

摘要翻译： 本发明提供了治疗关节炎疾病如类风湿性关节炎的药剂，其具有其活性成分是透明质酸和锌的复合物。 与其组分，透明质酸和锌单独相比，该复合物协同抑制滑膜细胞的增殖并抑制由滑膜细胞产生的基质金属蛋白酶MMP-9。