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    Remedies for joint diseases
    1.
    发明授权
    Remedies for joint diseases 有权
    联合疾病救治

    公开(公告)号：US06608043B1

    公开(公告)日：2003-08-19

    申请号：US09936245

    申请日：2001-09-07

    申请人： Isao Serizawa ,  Keisei Maekawa ,  Janos Illes ,  Erzsebet Neszmeli

    发明人： Isao Serizawa ,  Keisei Maekawa ,  Janos Illes ,  Erzsebet Neszmeli

    IPC分类号： A01N4304

    CPC分类号： A61K31/728 ,  A61K33/30 ,  A61K47/61 ,  Y10S514/825 ,  A61K31/715 ,  A61K2300/00

    摘要： The present invention provides an agent for treatment of arthritic diseases such as rheumatoid arthritis that has for its active ingredient a complex of hyaluronic acid and zinc. This complex synergistically inhibits proliferation of synovial cells and suppresses matrix metalloproteinase MMP-9, which is produced by synovial cells, as compared with its constituents, hyaluronic acid and zinc, alone.

    摘要翻译： 本发明提供了治疗关节炎疾病如类风湿性关节炎的药剂，其具有其活性成分是透明质酸和锌的复合物。 与其组分，透明质酸和锌单独相比，该复合物协同抑制滑膜细胞的增殖并抑制由滑膜细胞产生的基质金属蛋白酶MMP-9。

    Apparatus for the treatment of wet solids, especially pulpy materials, by heating or cooling
    4.
    发明授权
    Apparatus for the treatment of wet solids, especially pulpy materials, by heating or cooling 失效
    用于通过加热或冷却处理湿固体，特别是浆料的装置

    公开(公告)号：US4296072A

    公开(公告)日：1981-10-20

    申请号：US131825

    申请日：1980-03-19

    申请人： Istvan Takacs ,  Zoltan Banos ,  Janos Illes ,  Endre Vereczkey ,  Peter Rudolf ,  Gyorgy Kerey

    发明人： Istvan Takacs ,  Zoltan Banos ,  Janos Illes ,  Endre Vereczkey ,  Peter Rudolf ,  Gyorgy Kerey

    IPC分类号： B01D1/22 ,  A23L3/18 ,  A23L3/36 ,  A23L3/375 ,  B01D9/00 ,  B01D9/02 ,  B01D11/02 ,  B01F9/02 ,  B01J8/10 ,  B01J19/00 ,  F25D13/06 ,  F26B5/04 ,  F26B9/08 ,  F26B11/04 ,  F26B17/32 ,  F28D11/02 ,  B01D1/14 ,  B01D9/04 ,  B01D11/00

    CPC分类号： F25D13/06 ,  A23L3/185 ,  A23L3/361 ,  A23L3/375 ,  B01D9/0013 ,  F26B11/044 ,  F26B11/0445 ,  F26B11/049 ,  F26B5/041 ,  Y10S159/16

    摘要： Apparatus for the treatment, such as drying, freezing, crystallization of wet solids, slurries, suspensions, pulps and similar materials with heating or cooling.The apparatus is characterized by a treating body having two sections. The first section has a horizontally arranged axially flared annular treating drum rotatable around the horizontal or near-horizontal longitudinal rotation axis, and having end plates with a material feeding inlet pipe leading into the interior through one end plate, while the other end plate is provided with an opening arranged eccentrically in relation to the rotation axis. The second section of the treating body is connected rigidly and thus rotatably to the treating drum, the second section of the treating body having at least three duct-like oblong treating members leading into each other. The longitudinal axes of the treating members together form a zig-zag or similar line, and they intersect the rotation axis of the treating drum--which is the common axis of rotation of the treating drum and of the part forming the second section of the treating body and consisting of the treating members outside the treating drum.

    摘要翻译： 用于处理的装置，例如干燥，冷冻，湿固体结晶，浆料，悬浮液，纸浆和类似材料，具有加热或冷却。 该装置的特征在于具有两个部分的处理体。 第一部分具有水平布置的轴向扩张的环形处理鼓，其可围绕水平或近水平纵向旋转轴线旋转，并且具有端板，其具有通过一个端板通向内部的材料供给入口管，而提供另一个端板 具有相对于旋转轴偏心布置的开口。 处理体的第二部分刚性地连接并且因此可旋转地连接到处理滚筒，处理体的第二部分具有至少三个彼此相通的导管状长方形处理部件。 处理构件的纵向轴线一起形成锯齿形或类似的线，并且它们与处理滚筒的旋转轴线相交，处理滚筒的旋转轴线是处理滚筒和形成处理滚筒的第二部分的共同旋转轴线 由处理滚筒外的处理件组成。

    Process for the production of heparin-containing particulate products
    7.
    发明授权
    Process for the production of heparin-containing particulate products 失效
    生产含肝素颗粒产品的方法

    公开(公告)号：US4518771A

    公开(公告)日：1985-05-21

    申请号：US219853

    申请日：1980-12-23

    申请人： Istvan Takacs ,  Gyorgy Kerey ,  Janos Illes ,  Peter Rudolf ,  Pal Gere ,  Laszlo Czebe ,  Erzsebet Neszmelyi

    发明人： Istvan Takacs ,  Gyorgy Kerey ,  Janos Illes ,  Peter Rudolf ,  Pal Gere ,  Laszlo Czebe ,  Erzsebet Neszmelyi

    IPC分类号： C08B37/10

    CPC分类号： A61K31/715 ,  C08B37/0075

    摘要： A heparin-enriched material capable of long-term storage and particularly adapted for use as a raw material in processes for the extraction of heparin is produced by storing the animal organ material for a period of 0.5 to 15 hours (preferably 4 to 6 hours) at a temperature of 10.degree. to 50.degree. C. (preferably 30.degree. to 50.degree. C.), then injecting steam to effect a heat treatment at a temperature between 75.degree. and 100.degree. C. The heat treatment precipitates heparin-containing aggregate which is filtered from the aqueous phase and dried to a dry substance content of 90 to 95%.

    摘要翻译： 通过将动物器官材料储存0.5至15小时（优选4至6小时）来制备能够长期储存并特别适合用作肝素提取方法中的原料的富含肝素的材料， 在10〜50℃（优选30〜50℃）下，注入蒸汽，在75〜100℃的温度下进行热处理。热处理使含有肝素的骨料沉淀， 从水相中过滤并干燥至干物质含量为90至95％。